Structural bases of myocardial hypertrophy

Meessen, H

doi:10.1136/hrt.33.suppl.94

Cited by 29 publications

(4 citation statements)

References 5 publications

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“…In hypertrophied myocardium it was interesting to observe the increase of subsarcolemmal sarcoplasm with augmented amount of ribosomes and glycogen granules but not yet visible myofilaments. This seems characteristic for longitudinal growth of the muscle cells as it is described by Meessen (1971) in stepwise dove-tailing of the intercalated discs (Fig. 2).…”

Section: Resultsmentioning

confidence: 55%

Effect of ethanol infusion on the ultrastructure of human myocardium

Klein

Harmjanz

1975

Postgraduate Medical Journal

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SummaryTo study the influence of a moderate dose of ethanol on the ultrastructure of myocardium in patients with heart disease, a 7 5°/ solution of ethanol was infused in six patients with myocardial and valvular disease, who underwent diagnostic cardiac catheterization. Before and after infusion of ethanol an endomyocardial biopsy was performed and the specimens were examined by electron microscopy. After ethanol all six patients revealed alterations in the mitochondrial structure and three of them also showed significant dilatation of the sarcoplasmic reticulum. Cardiac output increased in three of the patients, whereas in two patients a decrease of cardiac output was measured.The results suggest that the infusion of even small amounts of ethanol is able to provoke structural alterations of myocardial cell organelles and, therefore, possible impairment of myocardial function.

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Section: Resultsmentioning

confidence: 55%

Effect of ethanol infusion on the ultrastructure of human myocardium

Klein

Harmjanz

1975

Postgraduate Medical Journal

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“…Die Herzhypertrophie ist gekennzeichnet durch die Zunahme des absoluten und relativen Herzgewichts auf der Basis einer Vermehrung der zytoplasmatischen Strukturen (Meessen 1967(Meessen , 1971 (1962/1971) werden damit best~tigt. In zwei Versuchen haben wir eine Hyperfunktion des Herzens durch ein Schwimmtraining erzwungen.…”

Section: Discussionunclassified

Wirkung von Wachstumshormon und Schwimmtraining auf das Herz der Ratte

1974

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“…Hypertrophied myocytes had large nuclei, some of which were positive for PCNA. This suggested that cardiomyocytes would be occurred polyploidization 7–9 . Cardiomyocyte hypertrophy, myocardial degeneration, infiltration of mononuclear cells (histiocytes: positive for ED1) and interstitial/perivascular fibrosis (stained blue by Masson’s trichrome) were also observed in the IVS of the heart ( Fig.…”

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confidence: 99%

Spontaneous Cardiac Hypertrophy in a Crl:CD(SD) Rat

et al. 2009

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Cardiac hypertrophy was observed in a 9-week-old Crl:CD(SD) rat that died unexpectedly. The animal was allocated to the control group of a toxicity study, and no abnormalities in its general conditions, body weight or food intake were observed. Necropsy revealed an increase in heart weight. Gross examination indicated cardiac enlargement with thickening of the right and left ventricular walls. Histopathological examination revealed hypertrophy of the cardiomyocytes in the right and left ventricular walls and the interventricular septum. Electron microscopic examination indicated bizarre nuclei and accumulation of an increased number of various sizes of mitochondria in the perinuclear region of the hypertrophied myocytes. Hypertrophied myocytes connected by intensely folded intercalated disks were also observed. Based on these findings, the animal was diagnosed with cardiac hypertrophy. This is the first case report of cardiac hypertrophy in this strain.

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Structural bases of myocardial hypertrophy

Cited by 29 publications

References 5 publications

Effect of ethanol infusion on the ultrastructure of human myocardium

Effect of ethanol infusion on the ultrastructure of human myocardium

Wirkung von Wachstumshormon und Schwimmtraining auf das Herz der Ratte

Spontaneous Cardiac Hypertrophy in a Crl:CD(SD) Rat

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