Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies

Mishra, Akaash K.; Hellert, Jan; Freitas, Natália; Guardado-Calvo, Pablo; Haouz, Ahmed; Fels, J. Maximilian; Maurer, Daniel P.; Abelson, Dafna M.; Bornholdt, Zachary A.; Walker, Laura M.; Chandran, Kartik; Cosset, François‐Loïc; McLellan, Jason S.; Rey, F.A.

doi:10.1126/science.abl6502

Cited by 28 publications

(27 citation statements)

References 56 publications

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“…In spite of this, heterodimerisation of Gn with Gc is important for bunyavirus GPC protein folding and localisation. 85 , 86 For instance, both CCHFV Gn and GP38 have been suggested to interact with Gc to enable viral particle assembly and infectivity. 87 , 88 Thus, there may be a potential role of Gn for ensuring the GPC antigen is correctly processed and formed in CCHFV vaccines.…”

Section: Discussionmentioning

confidence: 99%

Adenoviral vectored vaccination protects against Crimean-Congo Haemorrhagic Fever disease in a lethal challenge model

Saunders¹,

Gilbride²,

Dowall³

et al. 2023

eBioMedicine

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Section: Discussionmentioning

confidence: 99%

Adenoviral vectored vaccination protects against Crimean-Congo Haemorrhagic Fever disease in a lethal challenge model

Saunders¹,

Gilbride²,

Dowall³

et al. 2023

eBioMedicine

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“…Additionally, research on the neutralization mechanism of antibodies against CCHFV provides the molecular basis, which is essential for developing specific medical countermeasures. ADI-37801 and ADI-36121, two neutralizing antibodies, can recognize and bind CCHFV epitopes by blocking membrane fusion [ 77 ]. Following binding, DVD-121-801, a bispecific antibody, can provide therapeutic protection and become a strong candidate for therapeutic antibody cocktails [ 78 ].…”

Section: Tick-borne Virusmentioning

confidence: 99%

The Tick-Borne Pathogens: An Overview of China’s Situation

et al. 2023

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Background Ticks are important medical arthropods that can transmit hundreds of pathogens, such as parasites, bacteria, and viruses, leading to serious public health burdens worldwide. Unexplained fever is the most common clinical manifestation of tick-borne diseases. Since the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the surge of coronavirus disease 2019 (COVID-19) cases led to the hospital overload and fewer laboratory tests for tick-borne diseases. Therefore, it is essential to review the tick-borne pathogens and further understand tick-borne diseases. Purpose The geographic distribution and population of ticks in the Northern hemisphere have expanded while emerging tick-borne pathogens have been introduced to China continuously. This paper focused on the tick-borne pathogens that are threatening public health in the world. Their medical significant tick vectors, as well as the epidemiology, clinical manifestations, diagnosis, treatment, prevention, and control measures, are emphasized in this document. Methods In this study, all required data were collected from articles indexed in English databases, including Scopus, PubMed, Web of Science, Science Direct, and Google Scholar. Results Ticks presented a great threat to the economy and public health. Although both infections by tick-borne pathogens and SARS-CoV-2 have fever symptoms, the history of tick bite and its associated symptoms such as encephalitis or eschar could be helpful for the differential diagnosis. Additionally, as a carrier of vector ticks, migratory birds may play a potential role in the geographical expansion of ticks and tick-borne pathogens during seasonal migration. Conclusion China should assess the risk score of vector ticks and clarify the potential role of migratory birds in transmitting ticks. Additionally, the individual and collective protection, vector control, comprehensive surveillance, accurate diagnosis, and symptomatic treatment should be carried out, to meet the challenge. Graphical Abstract

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“…Considering that these experiments were performed in an immunocompromised IFN-signalingdeficient IFNAR À/À mouse model, the partial protection observed in this study supports the rationale for inclusion of N in a vaccine candidate for CCHFV. Recently, structural insights into the Gc trimer 135 (the only known target for NAbs) 136 or the secreted glycoprotein GP38 137 have highlighted their potential as vaccine targets that could be incorporated into Ad vaccines.…”

Section: Reviewmentioning

confidence: 99%

Adenovirus-based vaccines—a platform for pandemic preparedness against emerging viral pathogens

2022

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Zoonotic viruses continually pose a pandemic threat. Infection of humans with viruses for which we typically have little or no prior immunity, can result in epidemics with high morbidity and mortality. These epidemics can have public health and economic impact, and can exacerbate civil unrest or political instability. Changes in human behavior in the past few decades: increased global travel, farming intensification, the exotic animal trade, as well as the impact of global warming on animal migratory patterns, habitats and ecosystems, contribute to the increased frequency of cross-species transmission events. Investing in the pre-clinical advancement of vaccine candidates against diverse emerging viral threats is crucial for pandemic preparedness. Replication-defective adenoviral (Ad) vectors have demonstrated their utility as an outbreak-responsive vaccine platform during the SARS-CoV-2 pandemic. Ad vectors are easy to engineer, are amenable to rapid, inexpensive manufacturing, are relatively safe and immunogenic in humans, and importantly, and do not require specialized cold-chain storage, making them an ideal platform for equitable global distribution, or stockpiling. In this review, we discuss the progress in applying Ad-based vaccines against emerging viruses, and summarize their global safety profile, as reflected by their widespread geographic use during the SARS-CoV-2 pandemic.

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Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies

Cited by 28 publications

References 56 publications

Adenoviral vectored vaccination protects against Crimean-Congo Haemorrhagic Fever disease in a lethal challenge model

Adenoviral vectored vaccination protects against Crimean-Congo Haemorrhagic Fever disease in a lethal challenge model

The Tick-Borne Pathogens: An Overview of China’s Situation

Adenovirus-based vaccines—a platform for pandemic preparedness against emerging viral pathogens

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