Structural brain abnormalities in multiple sclerosis patients with major depression

Feinstein, Anthony; Roy, Peter J.; Lobaugh, Nancy J.; Feinstein, Karen; O’Connor, Paul; Black, Sandra E.

doi:10.1212/01.wnl.0000110316.12086.0c

Cited by 274 publications

(182 citation statements)

References 39 publications

Supporting

Mentioning

159

Contrasting

Unclassified

Order By: Relevance

“…There is little empirical evidence on relationship between lesion burden (assessed by MRI) and depression in MS. Feinstein et al concluded that the burden of demyelinating lesions was associated with the severity of depression [44]; we found that the level of depression correlated significantly with the number of T2 lesions on an MRI scan.…”

Section: Resultssupporting

confidence: 54%

Correlations between depression, cognitive status, functional scores, disability and lesion load in multiple sclerosis treated with interferon beta 1a

Maier

Bălaşa

Bajkó

et al. 2015

Acta Medica Marisiensis

View full text Add to dashboard Cite

Introduction: Depression and cognitive impairment are the most frequent mental disorders in multiple sclerosis (MS) and represent an important cause of morbidity and mortality. The aim of the study was to analyse the main determinants of depression in multiple sclerosis. Materials and methods: Thirty-two patients with relapsing remitting multiple sclerosis (RRMS), treated with Interferon Beta 1a, without relapses and corticosteroid treatment in the last 30 days, were included in the study. The mean age of the patients was 35.4±9.2 years, M/F ratio 0.33. Depression level was evaluated by the Romanian version of Beck Depression Inventory (BDI) and the cognitive function with Paced Auditory Serial Addition Test 3 (PASAT 3), Symbol Digit Modalities Test (SDMT). The functional status and disability level of the patients were evaluated with Multiple Sclerosis Functional Composite and Expanded Disability Status Scale. In all patients a cerebral MRI with intravenous contrast administration was performed using a 1.5T MRI device. Results: Twenty-three patients were free of depression (score 1-10), 4 patients presented mild mood disturbance (score 11-16), 3 borderline clinical depression (score 17-20) and 2 moderate depression (score 21-30). The mean BDI score was 8.71±7.16. BDI score correlated significantly with EDSS (R=0.38, p=0.03), PASAT 3 (R=-0.42, p=0.01), SDMT (R=-0.58, p=0.0007), Timed 25-Foot Walk (R=0.43, p=0.01) and 9-Hole Peg Test (R=0.45, p=0.008). From the EDSS functional scores, significant correlations were found with the urinary score (R=0.4, p=0.01) and sensitive score (R=0.49, p=0.004). BDI score correlated significantly with the total number of T2 lesions (R=0.31, p=0.05) while there was no correlation with the number of active lesions. Conclusions: The main determinants of depression in RRMS patients are the cognitive impairment, the affection of fine hand movements (9-HP), gait impairment (T25FT) and bladder and sensitive dysfunction.

show abstract

Section: Resultssupporting

confidence: 54%

Correlations between depression, cognitive status, functional scores, disability and lesion load in multiple sclerosis treated with interferon beta 1a

Maier

Bălaşa

Bajkó

et al. 2015

Acta Medica Marisiensis

View full text Add to dashboard Cite

show abstract

“…We considered psychiatric disorders as comorbidities, but arguably these conditions may be considered as symptoms or complications in some cases, given their association with structural changes in the brain (Feinstein et al. 2004). Finally, given observations in the general population (Wu et al.…”

Section: Discussionmentioning

confidence: 99%

Physical comorbidities increase the risk of psychiatric comorbidity in multiple sclerosis

et al. 2016

View full text Add to dashboard Cite

BackgroundRisk factors for psychiatric comorbidity in multiple sclerosis (MS) are poorly understood.ObjectiveWe evaluated the association between physical comorbidity and incident depression, anxiety disorder, and bipolar disorder in a MS population relative to a matched general population cohort.MethodsUsing population‐based administrative data from Alberta, Canada we identified 9624 persons with MS, and 41,194 matches. Using validated case definitions, we estimated the incidence of depression, anxiety disorder, and bipolar disorder, and their association with physical comorbidities using Cox regression, adjusting for age, sex, socioeconomic status, and index year.ResultsIn both populations, men had a lower risk of depression and anxiety disorders than women, as did individuals who were ≥45 years versus <45 years at the index date. The risk of bipolar disorder declined with increasing age. The risks of incident depression (HR 1.92; 1.82–2.04), anxiety disorders (HR 1.52; 1.42–1.63), and bipolar disorder (HR 2.67; 2.29–3.11) were higher in the MS population than the matched population. These associations persisted essentially unchanged after adjustment for covariates including physical comorbidities. Multiple physical comorbidities were associated with psychiatric disorders in both populations.ConclusionPersons with MS are at increased risk of psychiatric comorbidity generally, and some physical comorbidities are associated with additional risk.

show abstract

“…The participants with depression had more hyperintense lesions in the left inferior medial frontal region and greater atrophy of left anterior temporal regions. These structural abnormalities accounted for 42% of the depression variance (Feinstein 2004). It is interesting to note that these lesions are in neuroanatomical regions similar to those implicated in depression associated with other neurological conditions -the literature on depression following stroke also implicates left frontal regions (Robinson 1984).…”

Section: Medical Depressionmentioning

confidence: 96%

Depression, cardiac mortality and all-cause mortality

Seymour¹,

Benning²

2009

Adv. psychiatr. treat

View full text Add to dashboard Cite

SUMMARYDepression is an illness that kills. The links between depression and medical illness are well established and bi-directional, but evidence is mounting that depression increases mortality as well as morbidity in adults, particularly older adults. We examine the evidence that the increase in mortality in depression applies to all-cause mortality as well as cardiac mortality, and describe plausible physiological theories for the association. We conclude that excess mortality arising from depression is a major public health problem that is largely unrecognised and needs to be addressed by a range of clinicians.

show abstract

Structural brain abnormalities in multiple sclerosis patients with major depression

Abstract: Whereas both lesion burden and atrophy are important in the pathogenesis of depression in MS, psychosocial influences should also be considered.

Cited by 274 publications

References 39 publications

Correlations between depression, cognitive status, functional scores, disability and lesion load in multiple sclerosis treated with interferon beta 1a

Correlations between depression, cognitive status, functional scores, disability and lesion load in multiple sclerosis treated with interferon beta 1a

Physical comorbidities increase the risk of psychiatric comorbidity in multiple sclerosis

Depression, cardiac mortality and all-cause mortality

Contact Info

Product

Resources

About