STRUCTURAL CHANGES IN RATS LUNG UNDER THE INFlUENCE OF HISTAMINE AND SODIUM HYPOCHLORITE

Abstract

Influence of sodium hypochlorite (SH), histamine and their simultaneous action on structural features of respiratory part of rats lungs on 1 st, 7 th, 14 th day of the experiment and after the rehabilitation period (21st day) was investigated. Histamine has been shown to lead to a dose-dependent decrease in the lumen of the alveolus, increase the thickness of interalveolar walls, bronchial spasm, damage to mitochondria, endoplasmic reticulum, increase in the number of peroxisomes and lysosomes. Giving rats SH at a concentration of 20 mg/l causes dystrophic changes in the lung cells, increase of the connective tissue, reducing the area of the cross-section of the alveolus throughout the duration of this compound, whereas SH at a concentration of 5 mg/l leads to less severe pathological changes. At the simultaneous SH and histamine into the body there is a hydropic dystrophy due to damage to the structures of the endoplasmic reticulum and mitochondria, spasmation of bronchioles, increased surfactant production, and the increased of connective tissue. These changes are less pronounced in the simultaneous action of SH at a concentration of 5 mg/l and histamine in a dose of 8 μg/kg.