Structural Changes in Surface-Modified Polymers for Medical Applications

Pamuła, Elżbieta; Dryzek, E.

doi:10.12693/aphyspola.113.1485

Cited by 10 publications

(9 citation statements)

References 20 publications

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“…The design of the surface has to take into account the properties required for their final use, such as biocompatibility, adhesion, wear resistance, wettability, or optical behavior, among others. To adapt the material for a targeted purpose, several surface modifications can be carried out, including surface functionalization, modification of the crystallinity, creation of surface microdomains and morphology, or variations in the roughness and topography. − In particular, from a chemical point of view, several studies evidenced the significance of the control of both topography and functionality. An appropriate surface functionalization and patterning can lead to materials with adhesive − or lubricant, − biocompatible or antifouling, , or even superhydrophilic − or superhydrophobic properties.…”

Section: Introductionmentioning

confidence: 99%

Constructing Robust and Functional Micropatterns on Polystyrene Surfaces by Using Deep UV Irradiation

2013

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We report the preparation of different surface patterns based on the photo-cross-linking/degradation kinetics of polystyrene (PS) by using UV light. Upon exposure to UV light, PS can be initially cross-linked, whereas an excess of the exposure time or intensity provokes the degradation of the material. Typically photolithography employs either positive or negative photoresist layers that upon removal of either the exposed or the nonexposed areas transfer the pattern of the mask. Herein, we present a system that can be both negative and positive depending on several aspects, including the irradiation time, intensity, or presence of absorbing active species (photoinitiators) using a general setup. As a result of the optimization of the time of exposure and the use of an appropriate cover or the incorporation of an appropriate amount of photoinitiator (in this particular case IRG 651), different tailor-made surface patterns can be obtained. Moreover, changes of the chemical composition of the polystyrene using, for instance, block copolymers can lead to surface patterns with variable functional groups. In this study we describe the formation of surface patterns using polystyrene-block-poly(2,3,4,5,6-pentafluorostyrene) block copolymers. The introduction of fluorinated moieties clearly modifies the wettability of the films when compared with that of the same structures obtained with PS. As a consequence we present herein a patterning methodology that can simultaneously vary not only the morphology but also the surface chemical composition.

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Section: Introductionmentioning

confidence: 99%

Constructing Robust and Functional Micropatterns on Polystyrene Surfaces by Using Deep UV Irradiation

2013

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“…Thermal properties of all synthesized polymers are in close agreement with the literature data: PLA ( X c = 35% [ 29 ], T g = 55–65 °C, T m = 145–183 °C [ 30 , 31 ]); PCL ( T g = −60 °C, T m = 60 °C [ 32 ]; PLACL/50:50 ( T g = 4 °C, T m = 158 °C [ 33 ]); PCLGA of low Gly content ( T g = −60 °C, T m = 54 °C [ 34 , 35 ]). It is known that molecular weight, monomer composition, and crystalline and rigid amorphous fractions development strictly affect thermal properties of polymers [ 30 , 33 , 36 ].…”

Section: Resultsmentioning

confidence: 99%

A Comprehensive Investigation of the Structural, Thermal, and Biological Properties of Fully Randomized Biomedical Polyesters Synthesized with a Nontoxic Bismuth(III) Catalyst

et al. 2022

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Aliphatic polyesters are the most common type of biodegradable synthetic polymer used in many pharmaceutical applications nowadays. This report describes the ring-opening polymerization (ROP) of l-lactide (L-LA), ε-caprolactone (CL) and glycolide (Gly) in the presence of a simple, inexpensive and convenient PEG200-BiOct3 catalytic system. The chemical structures of the obtained copolymers were characterized by 1H- or 13C-NMR. GPC was used to estimate the average molecular weight of the resulting polyesters, whereas TGA and DSC were employed to determine the thermal properties of polymeric products. The effects of temperature, reaction time, and catalyst content on the polymerization process were investigated. Importantly, the obtained polyesters were not cyto- or genotoxic, which is significant in terms of the potential for medical applications (e.g., for drug delivery systems). As a result of transesterification, the copolymers obtained had a random distribution of comonomer units along the polymer chain. The thermal analysis indicated an amorphous nature of poly(l-lactide-co-ε-caprolactone) (PLACL) and a low degree of crystallinity of poly(ε-caprolactone-co-glycolide) (PCLGA, Xc = 15.1%), in accordance with the microstructures with random distributions and short sequences of comonomer units (l = 1.02–2.82). Significant differences in reactivity were observed among comonomers, confirming preferential ring opening of L-LA during the copolymerization process.

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“…More recently, a shift to surface modification of more advanced biodegradable polymers, such as the PLCL and other copolymers can be noted. 146,151,[289][290][291] It can be stated that, as biomaterials evolve, the substrate studied in surface modification evolves as well. It can thus be expected that the most promising biomaterials that are currently being developed will be the subject of future surface modification studies.…”

Section: Plasma Treatmentmentioning

confidence: 99%

Nonthermal Plasma Technology as a Versatile Strategy for Polymeric Biomaterials Surface Modification: A Review

et al. 2009

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In modern technology, there is a constant need to solve very complex problems and to fine-tune existing solutions. This is definitely the case in modern medicine with emerging fields such as regenerative medicine and tissue engineering. The problems, which are studied in these fields, set very high demands on the applied materials. In most cases, it is impossible to find a single material that meets all demands such as biocompatibility, mechanical strength, biodegradability (if required), and promotion of cell-adhesion, proliferation, and differentiation. A common strategy to circumvent this problem is the application of composite materials, which combine the properties of the different constituents. Another possible strategy is to selectively modify the surface of a material using different modification techniques. In the past decade, the use of nonthermal plasmas for selective surface modification has been a rapidly growing research field. This will be the highlight of this review. In a first part of this paper, a general introduction in the field of surface engineering will be given. Thereafter, we will focus on plasma-based strategies for surface modification. The purpose of the present review is twofold. First, we wish to provide a tutorial-type review that allows a fast introduction for researchers into the field. Second, we aim to give a comprehensive overview of recent work on surface modification of polymeric biomaterials, with a focus on plasma-based strategies. Some recent trends will be exemplified. On the basis of this literature study, we will conclude with some future trends for research.

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Structural Changes in Surface-Modified Polymers for Medical Applications

Cited by 10 publications

References 20 publications

Constructing Robust and Functional Micropatterns on Polystyrene Surfaces by Using Deep UV Irradiation

Constructing Robust and Functional Micropatterns on Polystyrene Surfaces by Using Deep UV Irradiation

A Comprehensive Investigation of the Structural, Thermal, and Biological Properties of Fully Randomized Biomedical Polyesters Synthesized with a Nontoxic Bismuth(III) Catalyst

Nonthermal Plasma Technology as a Versatile Strategy for Polymeric Biomaterials Surface Modification: A Review

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