“…10 The inner ear receives blood supply from the labyrinthine artery; temporary stasis of leukocytes is sufficient to cause permanent damage to the delicate inner ear structures. 11 In our patient, the white blood cell count findings supported the diagnosis of leukostasis. Notably, CNS infiltration can be successfully treated by CNS-directed chemotherapy followed by allogenetic stem cell transplantation, whereas sensorineural hearing loss does not respond to this therapy.…”
Bilateral sensorineural deafness and unilateral cochlear ossification have rarely been described in patients with chronic myeloid leukemia (CML). A 21-year-old man presented to a hospital with right-sided sudden hearing loss and tinnitus. He was diagnosed with CML. Five days later, sudden hearing loss appeared in the other ear. Abnormality of the right-sided inner ear structure was revealed by preoperative magnetic resonance imaging; honeycomb-like cochlear ossification was observed during cochlear implant surgery in the right ear. The patient’s auditory performance exhibited significant improvement after bilateral cochlear implantation in our hospital. Hematological disorders must be considered in patients with sensorineural hearing loss. Cochlear implantation is feasible in patients with CML who exhibit sensorineural deafness, but cochlear ossification should be carefully evaluated by means of preoperative imaging examinations.
“…10 The inner ear receives blood supply from the labyrinthine artery; temporary stasis of leukocytes is sufficient to cause permanent damage to the delicate inner ear structures. 11 In our patient, the white blood cell count findings supported the diagnosis of leukostasis. Notably, CNS infiltration can be successfully treated by CNS-directed chemotherapy followed by allogenetic stem cell transplantation, whereas sensorineural hearing loss does not respond to this therapy.…”
Bilateral sensorineural deafness and unilateral cochlear ossification have rarely been described in patients with chronic myeloid leukemia (CML). A 21-year-old man presented to a hospital with right-sided sudden hearing loss and tinnitus. He was diagnosed with CML. Five days later, sudden hearing loss appeared in the other ear. Abnormality of the right-sided inner ear structure was revealed by preoperative magnetic resonance imaging; honeycomb-like cochlear ossification was observed during cochlear implant surgery in the right ear. The patient’s auditory performance exhibited significant improvement after bilateral cochlear implantation in our hospital. Hematological disorders must be considered in patients with sensorineural hearing loss. Cochlear implantation is feasible in patients with CML who exhibit sensorineural deafness, but cochlear ossification should be carefully evaluated by means of preoperative imaging examinations.
“…The labyrinthine artery is responsible for supplying the cochlea and vestibular apparatus with blood, and even temporary stasis can cause irreversible damage to the delicate neuronal and vascular structures of the inner ear. 24 As histologic studies are the only way to confirm the etiology of the patient's otologic symptoms, we cannot be certain of the cause. However, given the extreme hyperleukocytosis with WBC of 685 000/µL, a diagnosis of leukostasis seems reasonable.…”
Section: Discussionmentioning
confidence: 99%
“…The labyrinthine artery is responsible for supplying the cochlea and vestibular apparatus with blood, and even temporary stasis can cause irreversible damage to the delicate neuronal and vascular structures of the inner ear. 24…”
In cases of bilateral, sudden onset sensorineural hearing loss, evaluation for systemic causes of otologic symptoms, including CML, should be considered.
“…Because the internal auditory artery is the final artery, the cochlea is considered susceptible to ischemia due to VBI and occlusive disease [8,32,[67][68][69][70]. VBI is sometimes associated with hearing loss and/or tinnitus [33][34][35][36][37][38][39][40]62,71,72].…”
Section: Hearing Loss Due To Vertebrobasilar Artery Insufficiencymentioning
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