Structural Changes of Collagen Components and Diminution of Nerves in Congenital Ureteropelvic Junction Obstruction

Murakumo, Masashi; Nonomura, Katsuya; Yamashita, Tetsufumi; Ushiki, Tatsuo; Abe, Kazuhiro; Koyanagi, Tomohiko

doi:10.1016/s0022-5347(01)64910-3

Cited by 90 publications

(47 citation statements)

References 18 publications

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“…There are many explanations for the decrease in the extension ability of the narrow segments, which lead to the functional discontinuity of ureteropelvic muscle contractions: disorders in muscular structure, atrophy or a decrease in the number of smooth muscle cells, a decrease in the number of ICC and nerve endings, and an increase in the collagen deposits between the muscular clusters. 16,17 Some researchers consider the intrinsic function disorder as the underlying mechanism of the obstruction, and suggest that morphologic changes are secondary. 18 Pacemaker cells which demonstrate spontaneous depolarization and are electrically associated with ureteral smooth muscle cells are required for pyeloureteral peristalsis.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical and electron microscopic examination of Cajal cells in ureteropelvic junction obstruction

Eken

Erdogan

Kuyucu

et al. 2013

CUAJ

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E311Cite as: Can Urol Assoc J 2013;7(5-6):e311-6. http://dx.doi.org/10.5489/cuaj.11293 Published online May 13, 2013 (early released September 10, 2012). AbstractObjective: We examine the ultrastructural configurations of Cajal cells by electron microscopy, as well as the quantitative changes occurring in Cajal cells by light microscopy. Methods: In total, 35 patients with ureteropelvic junction (UPJ) obstruction and 7 patients without obstruction were compared immunohistochemically with c-kit (CD117) to quantify the number of cells. On electron microscopic examination, 7 patients with UPJ obstruction and 3 patients without obstruction were compared to evaluate the changes which occurred in the ultrastructural configuration of the Cajal cells. Results: On light microscopic examination, it was determined that the Cajal cells, which demonstrate c-kit (CD117) immunoreactive character, were located near the circular muscle layer and parallel to the muscle cells. The number of Cajal cells in the control group was significantly increased compared to the number of cells in patients with UPJ obstruction (p < 0.001). On electron microscopic examination, the number of interstitial cells was also higher in the control group. A decrease in the number of the caveolae in these cells was seen in the group with UPJ obstruction compared to the control group. Conclusion: In UPJ obstruction, a decrease in the number of Cajal cells, as well as the changes in the morphologic structure of the Cajal cells, indicates that these cells have a role in the pacemaker system and are associated with ureteral peristalsis.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical and electron microscopic examination of Cajal cells in ureteropelvic junction obstruction

Eken

Erdogan

Kuyucu

et al. 2013

CUAJ

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“…The renal phenotype of ADAMTS-1 -/-mice resembles human ureteropelvic junction obstruction, which is the most common cause of congenital hydronephrosis and is recognized in nearly 1 in 500 live births (27). This disease is characterized by abnormal collagen and smooth muscle components at the ureteropelvic junction that contribute to mechanical or functional obstruction of urinary flow (27,28). Interestingly, the structural abnormalities in ADAMTS-1 -/-mice are responsible for the same dysfunctions described in cases of congenital ureteropelvic junction obstruction and primary obstructive megaureter in humans (29,30).…”

Section: Figurementioning

confidence: 99%

ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function

Shindo¹,

Kurihara²,

Kuno³

et al. 2000

J. Clin. Invest.

296

188

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“…Murakumo et al emphasized the importance of a multifaceted approach combining neurogenic and myogenic theories in understanding the etiopathogenesis of intrinsic UPJ obstruction (13). A recent non-invasive study, which focused on the measuring urinary TGF-β 1 in children with congenital UPJ obstruction confi rmed this urinary cytokine as a useful tool for the diagnosis and follow-up of UPJ obstruction (14).…”

Section: Discussionmentioning

confidence: 99%

Analysis of expression of TNF-alpha and TGF-beta3 in intrinsic ureteropelvic junction obstruction

Koca¹,

Kaya²,

Mi³

et al. 2013

BLL

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Abstract:Objectives: Ureteropelvic junction (UPJ) obstruction is of critical importance to understand the histopathology of UPJ obstruction in terms of therapy planning and follow-up. For this purpose, our study was conducted with TNF-α and TGF-β markers to investigate possible underlying problems in intrinsic UPJ obstruction. Methods: Of the patients who had undergone surgery in our clinic, 36 UPJ segments of patients who had undergone dismembered pyeloplasty surgery due to UPJ obstruction and 14 UPJ segments of the patients who had undergone nephrectomy were collected to form 2 groups. All histological sections were examined by applying immunohistochemical transforming growth factor beta 3 (TGF-β3) and tumour necrosis factor alpha (TNF-α) monoclonal antibody dyes. Results: The mean staining values for TNF-α in mucosal tissue and mucosa were 0.53±0.84 and 0.58±0.84, respectively in the obstruction group, whereas the values observed in the control group were 0.86±0.36 and 0.93±0.47, respectively. While the mean staining values in the obstruction group in mucosal tissue and mucosa for TGF-β3 were 1.75±0.73 and 2.17±0.77, respectively, the values established in the control group were 1.14±0.66 and 1.43±0.93, respectively. The difference between the obstruction and control groups were statistically signifi cant for both values (p<0.05). Conclusion: Only a limited number of studies have been carried out on this particular issue. Data from the present study indicate that TGF-β3 and TNF-α may play a role in the histopathogenesis of UPJ obstruction (Tab. 1, Fig. 1

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Structural Changes of Collagen Components and Diminution of Nerves in Congenital Ureteropelvic Junction Obstruction

Cited by 90 publications

References 18 publications

Immunohistochemical and electron microscopic examination of Cajal cells in ureteropelvic junction obstruction

Immunohistochemical and electron microscopic examination of Cajal cells in ureteropelvic junction obstruction

ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function

Analysis of expression of TNF-alpha and TGF-beta3 in intrinsic ureteropelvic junction obstruction

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