Structural characteristics of cardiomyocytes in the right atrium of NISAG rats

Максимов, В. Ф.; Korostyshevskaya, I. M.; Al, Markel'; Шмерлинг, М. Д.; Yakobson, G. S.

doi:10.1007/bf02694458

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…Thus, it was demonstrated the beneficial effects induced by aerobic training on the components from the secretory apparatus of cardiomyocyte. These findings are consistent with that of an early research, indicating that the production and secretion of NPs depend on the secretory apparatus activity of atrial cardiomyocytes 3 .…”

Section: Discussionsupporting

confidence: 93%

“…First, mice subjected to aerobic training exhibited a significant increase in the number and sizes of NP granules from cardiomyocytes compared to sedentary animals, indicating that aerobic training activated the biosynthetic process in cardiomyocytes 3 . These data confirm previously results obtained by Barletta et al 5 , Ohba et al 6 , Edwards 7 and Gutkowska et al 14 .…”

Section: Discussionmentioning

confidence: 98%

“…Studies have shown that specific atrium granules contain NP pro hormones 2 . The production and secretion of NPs depend on the structural components of the atrium cardiomyocytes including the Golgi apparatus, mitochondria, endoplasmic reticulum, the euchromatin and the number of pores in the nuclear membrane 3 .…”

Section: Introductionmentioning

confidence: 99%

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Effects of Aerobic Training on the Cardiomyocytes of the Right Atrium of Mice

Oliveira

Maifrino

Pithon‐Curi

et al. 2016

Rev Bras Med Esporte

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Introduction: Polypeptide hormones (natriuretic peptides, NPs) are secreted by the cardiac atria and play an important role in the regulation of blood pressure. Objective: To evaluate the effects of aerobic training on the secretory apparatus of NPs in cardiomyocytes of the right atrium. Methods: Nine-month-old mice were divided in two groups (n=10): control group (CG) and trained group (TG). The training protocol was performed on a motor treadmill for 8 weeks. Systolic blood pressure was measured at the beginning of the experiment (9 months of age) and at moment of the sacrifice (11 months of age). Electron micrographs were used to quantify the following variables: the quantitative density and area of NP granules, the relative volumes of the mitochondria, endoplasmic reticulum, and Golgi complex and the relative volume of euchromatin in the nucleus and the number of pores per 10 µm of the nuclear membrane. The results were compared by Student's t test (p< 0.05). Results: The cardiomyocytes obtained from TG mice showed increased density and sectional area of secretory granules of NP, higher relative volume of endoplasmic reticulum, mitochondria, and Golgi complex compared with the CG mice. Furthermore, the quantitative density of nuclear pores and the relative volume of euchromatin in the nucleus were significantly higher compared with the CG mice. Conclusion: Aerobic training caused hypertrophy of the secretory apparatus in the cardiomyocytes of right atrium, which could explain the intense synthesis of natriuretic peptides in trained mice with respect to the untrained mice.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Effects of Aerobic Training on the Cardiomyocytes of the Right Atrium of Mice

Oliveira

Maifrino

Pithon‐Curi

et al. 2016

Rev Bras Med Esporte

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Cardiac Natriuretic Peptides and Development of Hereditary Hypertension in Rats

Korostyshevskaya¹,

Максимов

et al. 2012

Bull Exp Biol Med

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Ultrastructure of the right atrial cardiomyocytes of suckling ISIAH rats was studied to clarify the role of cardiac natriuretic peptides in hypertension development during the period when blood pressure is not yet elevated. Cardiomyocytes diameter was significantly greater, Golgi complex was more developed, and granules in the sarcoplasm were more abundant in ISIAH rats as soon as on postnatal day 12 in comparison with age-matched normotensive animals. The smaller diameter of granules and their qualitative composition (ratio of forming, mature, and dissolving forms) attest to active synthesis and release of secretory product. In 21-day-old ISIAH rats, granule size and qualitative composition reflected increased accumulation of hormones in the cells. Thus, morphological features of increased production of natriuretic peptides in the right atrial myocytes were revealed in rats during the first postnatal month before manifestation of hereditary hypertension.

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