Structural characterization and DNA-binding properties of Sm(III) complex with ofloxacin using spectroscopic methods

Abstract

Abstract.A novel complex Sm(III) complex with ofloxacin was synthesized and characterized on the basis of elemental analyses, molar conductivities, IR spectra, thermal analysis (TG-DSC), 1 H-NMR spectra. Then, spectrometric titration, ethdium bromide displacement experiments by UV spectroscopy, ionic influence, viscosity measurements and Circular Dichroism (CD) spectroscopic measurements were conducted to characterize the interaction between the complex and CT-DNA. Results obtained indicate that the complex bound with CT-DNA via an intercalation mechanism. The binding constants and binding sites number of the Sm(III) complex with CT-DNA were 1.80 × 10 5 l·mol −1 and 1, respectively.

Mechanisms of the interaction between Pr(DNR)3 and Herring-Sperm DNA

“…[25][26][27][28] Thus, to further clarify the interaction between Pr(DNR) 3 and DNA, viscosity measurements were performed. A classical intercalation model is known to cause a significant increase in the viscosity of a DNA solution due to an increase in the length of the DNA helix.…”

Spectroscopic studies on the interaction between tryptophan–erbium(III) complex and herring sperm DNA

“…Optical photophysical probe provides necessary but not sufficient clues to support binding modes, whereas hydrodynamic measurements which are sensitive to the length change are regarded as the most critical tests of a binding model in solution [25][26][27]. Thus, to further clarify the interaction between Er(III)(Trp) 3 and DNA, we carried out viscosity measurements.…”

Interaction of Irbesartan with Bovine Hemoglobin Using Spectroscopic Techniques and Molecular Docking

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