Structural characterization of a homopolysaccharide with hypoglycemic activity from the roots of Pueraria lobata

Abstract

A water-soluble neutral homopolysaccharide (PLP-1) was obtained from the roots of Pueraria lobata by DEAE cellulose and Sephadex G-200 gel chromatography purification.

Effect of Sleeve Gastrectomy on Glycometabolism via Forkhead Box O1 (FoxO1)/Lipocalin-2 (LCN2) Pathway

“…FOXO1 is the main regulator of redox balance in osteoblasts. When high glucose induces an increase in oxidative stress, it can stimulate FOXO1 secretion [ 34 – 36 ]. Via integrated signals originating from the bone, FOXO1 can change the function and mass of pancreatic β cells.…”

“…Mosialou et al also found that the upregulation of LCN2 is a protective mechanism against glucose intolerance caused by obesity by reducing food intake and promoting adaptive β-cell proliferation. Osteoblast-derived LCN2 suppress appetite and reduce fat mass, while improving glucose metabolism [ 34 ]. Both FOXO1 and LCN2 can be secreted by osteoblasts, and can participate in regulation of glucose metabolism by affecting the mechanism of insulin resistance during the pathogenesis of diabetes.…”

Based on Plasma Metabonomics and Network Pharmacology Exploring the Therapeutic Mechanism of Gynura procumbens on Type 2 Diabetes

“…Finally, membranes were incubated with an ECL kit for visualization (Yeason, Shanghai, China). The density of each band was quantified using Image Lab software (Qian et al, 2020).…”

Structural characterization, anti-inflammatory and glycosidase inhibitory activities of two new polysaccharides from the root of Pueraria lobata

“…It has been shown that the polysaccharide PLP-1 extracted from P. lobata has a hypoglycemic effect in vitro. 24 In our laboratory's early stages of research, the crude polysaccharide PL70-1 was extracted and separated from P. lobata by hot water extraction and ethanol precipitation method, and the polysaccharide PL70-1-1 was then puried by column chromatography, and proved that they have a hypoglycemic effect. 25 The isolation and identication of polysaccharides from P. lobata and the explanation of its biological activity need to be further studied.…”