Structural characterization of new zinc(ii) complexes with N₂O₂ chelating thiosemicarbazidato ligands; investigation of the relationship between their DNA interaction and in vitro antiproliferative activity towards human cancer cells

Abstract

New candidates to become DNA-targeting antiproliferative agents: Zinc(ii) complexes bearing N2O2-thiosemicarbazidato ligands.

Anticancer activity of Ni(ii) and Zn(ii) complexes based on new unsymmetrical salophen-type ligands: synthesis, characterization and single-crystal X-ray diffraction

“…Previous studies have demonstrated that presence of a methoxy group (–OCH 3 ) in some molecules can significantly increase biological activity, particularly antiproliferative performance. 42,46,72,73 Unsubstituted Ni II -L 1 (with R = H) did not present antiproliferative activity in any of the tested cell lines (IC 50 > 100 μM). In contrast, its methoxy-containing derivative Ni II -L 2 (with R = –OCH 3 ) was the most potent anticancer agent (IC 50 = 3.4–11.3 μM).…”

“…Therefore, it was not possible to establish a clear correlation when including the methoxy group, in agreement with previous reports. 42,46,72,73 More salophen derivatives are required to assess the role played by substituents (R = H or -OCH 3 ) in the aromatic rings and further studies to examine the pathways of action through which these kinds of complexes act.…”

Revealing the supramolecular features of two Zn(ii) complexes derived from a new hydrazone ligand: a combined crystallographic, theoretical and antibacterial study

“…31 In the last few years different classes of zinc coordination complexes have shown good potential in diverse applications, in nonlinear optics, in photo-catalysis and in several diseases, and as anti-inflammatory, anti-diabetic, antimicrobial, antioxidant, and antitumor agents. [32][33][34][35][36][37][38][39][40] As a part of our efforts to explore the non-covalent interactions in coordination compounds, herein, we have designed and prepared two Zn(II) complexes (1 and 2) using a newly synthesized [(1-methylimidazol-2-yl)methylene] isonicotinohydrazide [HL] ligand in aqueous medium. Single crystal X-ray analysis shows that complex 1 is a distorted octahedron whereas complex 2 is a distorted tetrahedron in nature.…”

“…31 In the last few years different classes of zinc coordination complexes have shown good potential in diverse applications, in nonlinear optics, in photo-catalysis and in several diseases, and as anti-inflammatory, anti-diabetic, antimicrobial, antioxidant, and antitumor agents. 32–40…”