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A series of new benzimidazolium salts and ruthenium­(II) complexes containing chelating N-heterocyclic carbenes (NHCs) functionalized with a benzylic group and an acetal group were prepared. All of the synthesized compounds were characterized by elemental analysis and NMR spectroscopy, and the molecular structures of 2c and 2d were determined by X-ray crystallography. All of the complexes were tested in the alkylation of cyclic amine derivatives with alcohols and showed excellent activity in this reaction. Cyclic amines were alkylated with primary and heteroaromatic alcohols. The Ru–NHC complexes also catalyzed N,C3-dialkylation of cyclic amines.

[Ni(C H N O ) (H O) ]•3(C H NO) (1) and [Co(C H N O ) (H O) ]•3(C H NO) (2) are synthesized and characterized by elemental analysis, FT-IR spectra, magnetic susceptibility, and thermal analysis. In addition, the crystal structure of Ni(II) complex is presented. Both complexes show distorted octahedral geometry. In 1 and 2, metal ions are coordinated by two oxygen atoms of salicylic residue and two nitrogen atoms of maleic amide residue from two ligands, and two oxygen atoms from two water molecules. In this paper, both compounds showed excellent inhibitory effects against human carbonic anhydrase (hCA) isoforms I, and II, α-glycosidase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Compounds 1 and 2 had Ki values of 18.36 ± 4.38 and 26.61 ± 7.54 nM against hCA I and 13.81 ± 3.02 and 29.56 ± 6.52 nM against hCA II, respectively. On the other hand, their Ki values were found to be 487.45 ± 54.18 and 453.81 ± 118.61 nM against AChE and 199.21 ± 50.35 and 409.41 ± 6.86 nM against BChE, respectively.

The synthesis, X-ray structure, spectroscopic and catalytic properties of sterically hindered Schiff-base ligands (L 1 H = N-[allylamine]-3,5-di-tert-butyl salicylaldimine, L 2 H=N-[2-amino-5-methyl pyridine]-3,5-di-tert-butyl salicylaldimine and L 3 H=N-[2-amino-6-methyl pyridine]-3,5-di-tert-butyl salicylaldimine), and their mononuclear Cu(II) complex for L 1 H with multinuclear Cu(II) complexes for L 2 H and L 3 H, were described. The copper(II) complexes of these ligands were synthesized by treating an methanolic solution of the appropriate ligand with an appropriate amount of CuCl 2 Á2H 2 O. The ligands and their copper(II) complexes were characterized by FT-IR, UV-Vis, 1 H-NMR, elemental analysis, measurement of room temperature magnetic moment, and X-ray structural determination. The reaction of the L 2 H and L 3 H ligands in a 1:1 mol ratio with CuCl 2