Synthesis, crystal structure and biological evaluation of spectroscopic characterization of Ni(II) and Co(II) complexes with N‐salicyloil‐N′‐maleoil‐hydrazine as anticholinergic and antidiabetic agents

Abstract

[Ni(C H N O ) (H O) ]•3(C H NO) (1) and [Co(C H N O ) (H O) ]•3(C H NO) (2) are synthesized and characterized by elemental analysis, FT-IR spectra, magnetic susceptibility, and thermal analysis. In addition, the crystal structure of Ni(II) complex is presented. Both complexes show distorted octahedral geometry. In 1 and 2, metal ions are coordinated by two oxygen atoms of salicylic residue and two nitrogen atoms of maleic amide residue from two ligands, and two oxygen atoms from two water molecules. In this paper, both compounds showed excellent inhibitory effects against human carbonic anhydrase (hCA) isoforms I, and II, α-glycosidase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Compounds 1 and 2 had Ki values of 18.36 ± 4.38 and 26.61 ± 7.54 nM against hCA I and 13.81 ± 3.02 and 29.56 ± 6.52 nM against hCA II, respectively. On the other hand, their Ki values were found to be 487.45 ± 54.18 and 453.81 ± 118.61 nM against AChE and 199.21 ± 50.35 and 409.41 ± 6.86 nM against BChE, respectively.

Synthesis, characterization, molecular docking and biological activities of novel pyrazoline derivatives

“…However, rivastigmine has an equal affinity for AChE enzyme and that is very momentous drug, which is prescribed for the therapy of AD . It showed well which phenothiazines were observed to inhibit ChE, especially AChE . This important enzyme was very strongly inhibited by novel pyrazoline derivatives ( P1 – 7 ; Table and Figure ).…”

Tannic acid as a natural antioxidant compound: Discovery of a potent metabolic enzyme inhibitor for a new therapeutic approach in diabetes and Alzheimer's disease

“…Indeed, the important role of cholinesterase enzymes in neural transmission makes them the primary target of a large number of cholinesterase-inhibiting toxins and drugs, which are beneficial for agriculture and new drugs that need to be prepared, although there is less interest in the new toxins like tacrine, donepezil, rivastigmine, and galantamine, four cholinesterase inhibitor molecules that are recorded for the therapy of AD. [44][45][46][47][48] Indeed, the galantamine molecule is an allosterically potentiating ligand of nicotinic ACh receptors. By making the remaining nicotinic ACh receptors more sensitive to ACh, this drug may induce a stronger response.…”

Anticholinergic, antidiabetic and antioxidant activities of cinnamon ( cinnamomum verum ) bark extracts: polyphenol contents analysis by LC-MS/MS

“…The inhibitory effects of WEC and EEC on α-glycosidase enzyme were performed according to the previous method. [85] For this aim, different concentrations of WEC and EEC were added to phosphate buffer (75 μL, pH = 7.4). Then, 20 μL of α-glycosidase solution in indicated buffer was added and incubated for 10 min.…”