Structural damages in adsorbed vaccines affected by freezing

Kurzątkowski, W; Kartoğlu, Ümit; Staniszewska, Monika; Górska, Paulina; Krause, Aleksandra; Wysocki, Mirosław J

doi:10.1016/j.biologicals.2011.10.011

Cited by 36 publications

(24 citation statements)

References 12 publications

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“…Hence, viral diseases that usually require a Th1-mediated immunity and CTL activation for protection may not fully benefit from employing aluminum as an adjuvant. Importantly, aluminum salts render absorbed vaccines more susceptible to freeze and thaw stress resulting in vaccine structural damages and agglomeration [59,60]. In addition, alum absorption can induce destabilization of the conformational structure of the antigen or epitopes [61].…”

Section: Classes Of Adjuvants Tested For Vlp-based Vaccinesmentioning

confidence: 99%

Adjuvant formulations for virus-like particle (VLP) based vaccines

Cimica

Galarza

2017

Clinical Immunology

103

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The development of virus-like particle (VLP) technology has had an enormous impact on modern vaccinology. In order to optimize the efficacy and safety of VLP-based vaccines, adjuvants are included in most vaccine formulations. To date, most licensed VLP-based vaccines utilize the classic aluminum adjuvant compositions. Certain challenging pathogens and weak immune responder subjects may require further optimization of the adjuvant formulation to maximize the magnitude and duration of the protective immunity. Indeed, novel classes of adjuvants such as liposomes, agonists of pathogen recognition receptors, polymeric particles, emulsions, cytokines and bacterial toxins, can be used to optimize the immunostimulatory activity of a VLP-based vaccine. This review describes the current advances in adjuvant technology for VLP-based vaccines directed at viral diseases, and discusses the basic principles for designing adjuvant formulations for enhancing the vaccine immunogenicity.

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Section: Classes Of Adjuvants Tested For Vlp-based Vaccinesmentioning

confidence: 99%

Adjuvant formulations for virus-like particle (VLP) based vaccines

Cimica

Galarza

2017

Clinical Immunology

103

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“…Assays for the detection of damages to vaccine formulations induced by freezing have been published. 32,33 Attempts have been made to overcome the sensitivity to freezing by adding lyoprotectants, such as trehalose, to the preparations. 34,35 Aluminum adjuvants failed to provide satisfactory augmentation of the immune response against a number of infectious diseases, such as with influenza and typhoid fever vaccines.…”

Section: Limitations To the Applicability Of Mineral Adjuvantsmentioning

confidence: 99%

Mineral Adjuvants∗∗The present chapter is an updated version of the chapter “Mineral Adjuvants,” published in Immunopotentiators in Modern Vaccines, p. 217–233. Ed. Virgil Schijns & Derek O'Hagan, Elsevier Science Publishers (2005).

Lindblad¹,

Duroux²

2017

Immunopotentiators in Modern Vaccines

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“…These vaccines, however, can be freeze sensitive, especially if adjuvanted with aluminum salts, which may collapse on freezing, lowering the adjuvant effect [16] . A recent study in the United States found a surprisingly high number of accidental exposures to freezing temperatures for vaccine vials labeled for storage at 2–8°C due to inappropriate shipping or interim storage at storage at health centers [17,18] .…”

Section: The Inherent Temperature Sensitivity Of Vaccinesmentioning

confidence: 99%

Tools and approaches to ensure quality of vaccines throughout the cold chain

Kartoğlu

Milstien

2014

Expert Review of Vaccines

121

119

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The Expanded Program on Immunization was designed 40 years ago for two types of vaccines: those that are heat stable but freeze sensitive and those that are stable to freezing but heat labile. A cold chain was developed for transport and storage of such vaccines and established in all countries, despite limited access to resources and electricity in the poorest areas. However, cold chain problems occur in all countries. Recent changes to vaccines and vaccine handling include development and introduction of new vaccines with a wide range of characteristics, improvement of heat stability of several basic vaccines, observation of vaccine freezing as a real threat, development of regulatory pathways for both vaccine development and the supply chain, and emergence of new temperature monitoring devices that can pinpoint and avoid problems. With such tools, public health groups have now encouraged development of vaccines labeled for use in flexible cold chains and these tools should be considered for future systems.

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Structural damages in adsorbed vaccines affected by freezing

Cited by 36 publications

References 12 publications

Adjuvant formulations for virus-like particle (VLP) based vaccines

Adjuvant formulations for virus-like particle (VLP) based vaccines

Mineral Adjuvants∗∗The present chapter is an updated version of the chapter “Mineral Adjuvants,” published in Immunopotentiators in Modern Vaccines, p. 217–233. Ed. Virgil Schijns & Derek O'Hagan, Elsevier Science Publishers (2005).

Tools and approaches to ensure quality of vaccines throughout the cold chain

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