Structural determination of the O-antigenic polysaccharide from Salmonella Mara (O:39)

Gajdus, Jerzy; Kaczyński, Zbigniew; Smietana, Joanna; Stepnowski, Piotr

doi:10.1016/j.carres.2009.02.015

Cited by 3 publications

(2 citation statements)

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“…In addition, structures of two Salmonella O antigens were revised in this work. Using known regularities in the 13 C‐NMR chemical shifts of the Qui p 3NAc‐(α1→3)‐ d ‐Man p disaccharide (Shashkov et al ., ), the absolute configuration of Qui3NAc in the O39 antigen was revised from l (Gajdus et al ., ) to d . In the O62 antigen, d ‐GalNAcA is present in the amide form ( d ‐GalNAcAN) rather than as the free acid (Vinogradov et al ., ).…”

Section: Chemical Composition and Structures For Salmonella Glcnac‐/gmentioning

confidence: 99%

“…In addition, structures of two Salmonella O antigens were revised in this work. Using known regularities in the 13 C-NMR chemical shifts of the Quip3NAc-(a1?3)-D-Manp disaccharide (Shashkov et al, 1988), the absolute configuration of Qui3NAc in the O39 antigen was revised from L (Gajdus et al, 2009) to D. In the O62 antigen, D-GalNAcA is present in the amide form (D-GalNAcAN) rather than as the free acid (Vinogradov et al, 1992). This was demonstrated by the 1 H-NMR spectrum of a polysaccharide sample measured in a 9:1 H 2 O/D 2 O mixture, which showed two signals for NH 2 protons at 7.40 and 7.65 ppm [compare published data (Rundlof et al, 1998)].…”

Section: Chemical Composition and Structures For Salmonella Glcnac-/gmentioning

confidence: 99%

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Structural diversity inSalmonellaO antigens and its genetic basis

et al. 2014

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This review covers the structures and genetics of the 46 O antigens of Salmonella, a major pathogen of humans and domestic animals. The variation in structures underpins the serological specificity of the 46 recognized serogroups. The O antigen is important for the full function and virulence of many bacteria, and the considerable diversity of O antigens can confer selective advantage. Salmonella O antigens can be divided into two major groups: those which have N-acetylglucosamine (GlcNAc) or N-acetylgalactosamine (GalNAc) and those which have galactose (Gal) as the first sugar in the O unit. In recent years, we have determined 21 chemical structures and sequenced 28 gene clusters for GlcNAc-/GalNAc-initiated O antigens, thus completing the structure and DNA sequence data for the 46 Salmonella O antigens. The structures and gene clusters of the GlcNAc-/GalNAc-initiated O antigens were found to be highly diverse, and 24 of them were found to be identical or closely related to Escherichia coli O antigens. Sequence comparisons indicate that all or most of the shared gene clusters were probably present in the common ancestor, although alternative explanations are also possible. In contrast, the better-known eight Gal-initiated O antigens are closely related both in structures and gene cluster sequences.

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Section: Chemical Composition and Structures For Salmonella Glcnac‐/gmentioning

confidence: 99%

Section: Chemical Composition and Structures For Salmonella Glcnac-/gmentioning

confidence: 99%

Structural diversity inSalmonellaO antigens and its genetic basis

et al. 2014

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Structure of O-Antigens

Knirel

2011

Bacterial Lipopolysaccharides

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Immunochemical studies of SalmonellaDakar and SalmonellaTelaviv O-antigens (serogroup O:28)

Dziadziuszko

Kumirska

Muża

et al. 2011

FEMS Microbiol Lett

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Salmonella Dakar and Salmonella Telaviv bacteria belong to serogroup O:28, which represents 107 serovars and possesses only the epitope O28. Salmonella Telaviv has the subfactors O28(1) and O28(2) , whereas S. Dakar has O28(1) and O28(3) . So far, only limited serological and immunological information for this serogroup is available in the literature. Knowledge of the structures of their O-polysaccharides and the immunochemical investigations performed in this work allowed to reveal the nature of subfactor O28(1) as attributed to the presence of 3-linked (or 3,4-disubstituted) α-d-GalpNAc in the main chains of S. Dakar and S. Telaviv O-polysaccharides. An explanation for the cross-reactions between Salmonella enterica O28 O-antigens and other Salmonella O-polysaccharides and their structural similarity to Escherichia coli O-serogroups is also given.

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Structural determination of the O-antigenic polysaccharide from Salmonella Mara (O:39)

Cited by 3 publications

References 15 publications

Structural diversity inSalmonellaO antigens and its genetic basis

Structural diversity inSalmonellaO antigens and its genetic basis

Structure of O-Antigens

Immunochemical studies of SalmonellaDakar and SalmonellaTelaviv O-antigens (serogroup O:28)

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