Structural differences in the hippocampus and amygdala of behaviorally inhibited macaque monkeys

Villard, Justine; Bennett, Jeffrey; Bliss‐Moreau, Eliza; Capitanio, John P.; Amaral, David G.; Lavenex, Pierre

doi:10.1002/hipo.23329

Cited by 10 publications

(7 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In previous studies, we found that DU20 and ST36 are frequently used acupuncture points for the treatment of ischemic cerebrovascular diseases [19]. Therefore, we selected these two acupoints as the targets of electroacupuncture in this experiment [18,20]. Our MWM results showed that the time it took for the electroacupuncture group to find a platform in the place navigation test was significantly shorter than that of the VaD group, especially in the last 3 days.…”

Section: Discussionmentioning

confidence: 96%

“…In addition, the number of Sirt1 positive cells in the hippocampal CA1 region and amygdala of the electroacupuncture group was significantly more than that of the VaD group, and the average gray value of Sirt1 was significantly lower than that of the VaD group. Through the results of westernt blot and immunohistochemistry experiments, we can conclude that electroacupuncture can reduce the inflammatory response in the brain tissue of VaD rats, and it may be mediated by regulating the Sirt1/STAT3 signaling pathway[18,23].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of electroacupuncture on the expression of Sirt1 and STAT3 in hippocampus and amygdala of vascular dementia rats

Zhao¹,

Li²,

Wang³

et al. 2022

NeuroReport

View full text Add to dashboard Cite

Objective Inflammation has long been considered a key factor in learning and memory impairment in patients with vascular dementia (VaD). Studies have confirmed that electroacupuncture can improve the learning and memory impairment of patients with VaD by reducing inflammation, but the specific mechanism of this effect is still unclear. The aim of this study was to explore the underlying mechanism of electroacupuncture in the treatment of VaD. MethodsThe vascular dementia animal model was established by bilateral occlusion of common carotid arteries, and electroacupuncture treatment was given at Baihui (DU20) and Zusanli (ST36). The morris water maze (MWM) was used to test the spatial learning and memory ability of rats in each group. To evaluate the expression of Sirtuin1 (Sirt1), Signal transducer and activator of transcription 3 (STAT3) and inflammatory cytokine (IL-17) in the hippocampus and amygdala, immunohistochemistry and western blot were performed. Results:The MWM test and Nissl staining results show that electroacupuncture can significantly improve the learning and memory impairment of VaD rats, and can repair damaged neurons. Immunohistochemistry and western blot results showed that electroacupuncture could enhance the expression of sirt1 in VaD rats, on the contrary, the expression of STAT3 and IL-17 was reduced due to electroacupuncture. ConclusionsThe result suggests that electroacupuncture can suppress inflammation through the Sirt1/STAT3 pathway and improve spatial learning and memory in VaD rats.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

The effect of electroacupuncture on the expression of Sirt1 and STAT3 in hippocampus and amygdala of vascular dementia rats

Zhao¹,

Li²,

Wang³

et al. 2022

NeuroReport

View full text Add to dashboard Cite

show abstract

“…In the amygdala these cells develop during critical ages for amygdala-dependent adolescent socioemotional development 6,8,84 . Almost half of all lifetime mental health conditions onset during mid-teenage years 85 , and changes in amygdala volume and development are linked to social and emotional disorders 6,[86][87][88][89][90] . Connections between the unique trajectory of PL maturation and neuropsychiatric disorders are beginning to be explored, with some evidence for reduced maturation in MDD 46 (which was not certified by peer review) is the author/funder.…”

Section: Discussionmentioning

confidence: 99%

Mouse paralaminar amygdala excitatory neurons migrate and mature during adolescence

Alderman

Saxon

Torrijos-Saiz

et al. 2022

Preprint

View full text Add to dashboard Cite

The human amygdala paralaminar nucleus (PL) contains immature excitatory neurons that exhibit protracted maturation into adolescence; however, whether a similar population exists in mice is unknown. We discovered a previously undescribed region with immature doublecortin (Dcx)+ excitatory neurons adjacent to the mouse basolateral amygdala, and similar to humans, these neurons mature during adolescence and are distinct from adjacent intercalated cells. Despite their immature features, these neurons are born during embryogenesis, populate the mouse PL prior to birth, and remain in an immature stage of development until adolescence. In the postnatal brain, a subpopulation of these excitatory neurons surprisingly migrate into the neighboring endopiriform cortex, peaking between P21-P28. In humans, cells with the molecular identity of mouse PL neurons populate the PL as early as 18 gestational weeks, and also exhibit migratory morphology into adolescence (13 years). The finding of a similar region in both mice and humans suggests a potentially conserved cellular mechanism for neuron recruitment and migration during adolescence, a key time period for amygdala circuit maturation and behavioral changes.

show abstract

“…NHPs may spontaneously present depression- and anxiety-like behaviors (Xu et al, 2015 ; Chu, 2019 ) but their detection depends on careful observation of a large population of animals. As a modeling alternative, disrupted husbandry or separation, either short or long-term, from either a parent or other social partner has been used to elicit a depressed- or anxious-like condition in both marmosets and macaques (Harlow and Suomi, 1971 ; Erickson et al, 2005 ; Winslow, 2005 ; O’Connor and Cameron, 2006 ; Spinelli et al, 2012 ; Zhang et al, 2016 ; French, 2019 ; Villard et al, 2021 ; Wood et al, 2021 ).…”

Section: Assessing Depression- and Anxiety-like Behaviors In Nhpsmentioning

confidence: 99%

Evaluating depression- and anxiety-like behaviors in non-human primates

Ausderau

Colman

Kabakov

et al. 2023

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Depression and anxiety are some of the most prevalent and debilitating mental health conditions in humans. They can present on their own or as co-morbidities with other disorders. Like humans, non-human primates (NHPs) can develop depression- and anxiety-like signs. Here, we first define human depression and anxiety, examine equivalent species-specific behaviors in NHPs, and consider models and current methods to identify and evaluate these behaviors. We also discuss knowledge gaps, as well as the importance of evaluating the co-occurrence of depression- and anxiety-like behaviors in animal models of human disease. Lastly, we consider ethical challenges in depression and anxiety research on NHPs in order to ultimately advance the understanding and the personalized treatment of these disorders.

show abstract

Structural differences in the hippocampus and amygdala of behaviorally inhibited macaque monkeys

Cited by 10 publications

References 98 publications

The effect of electroacupuncture on the expression of Sirt1 and STAT3 in hippocampus and amygdala of vascular dementia rats

The effect of electroacupuncture on the expression of Sirt1 and STAT3 in hippocampus and amygdala of vascular dementia rats

Mouse paralaminar amygdala excitatory neurons migrate and mature during adolescence

Evaluating depression- and anxiety-like behaviors in non-human primates

Contact Info

Product

Resources

About