Structural, fluoride release, and 3D interfacial adhesion analysis of bioactive endodontic sealers

AlMaimouni, Yara Khalid; Hamid, Shorouq Khalid; Ilyas, Kanwal; Shah, Asma Tufail; Majeed, Abdul; Khan, Abdul Samad

doi:10.4012/dmj.2019-064

Cited by 11 publications

(9 citation statements)

References 26 publications

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“…SEM analysis for BioRoot expressed evident formation of very defined and diverse precipitates (needle-like + spherical) when incubated pbs; and a little less defined and uniform (spherical) when incubated in sbf. The elemental analysis (SEM/EDS) confirmed the higher concentration of calcium and phosphate in the precipitates, according to the literature [8,27,[33][34][35]. Under FTIR/ATR and XRD analyses, BioRoot presented expressive peaks of calcium carbonate and carbonated hydroxyapatite when incubated in pbs and sbf; endorsing the findings from SEM analysis.…”

Section: Discussionsupporting

confidence: 75%

Impact of Immersion Media on Physical Properties and Bioactivity of Epoxy Resin-Based and Bioceramic Endodontic Sealers

et al. 2022

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This study assessed the effects of immersion media [distilled water (dw), phosphate buffered saline (pbs) and simulated body fluid (sbf)] in the physical properties [fluid uptake/sorption/solubility and alkalinization activity (pH)] and bioactivity of a bioceramic sealer: the BioRoot RCS (BioRoot) (Septodont). The epoxy-resin sealer AH Plus (Dentsply) was used as comparison. Sealers were immersed in dw, pbs and sbf to evaluate the fluid uptake/sorption/solubility and pH’s media. Bioactivity was assessed with SEM/EDS, FTIR-ATR and XRD. BioRoot solubility was as follows: sbf > pbs = dw. BioRoot had alkaline pH, and AH Plus had neutral pH, regardless of the medium. BioRoot presented mineral precipitates and peaks indicating hydroxyapatite-precursors in pbs and sbf. AH Plus physical properties were not affected by immersion media and it had no bioactivity. pbs and sbf should be preferred to investigate bioceramic sealers over distilled water, because they were able to highlight the sealer properties. BioRoot maintained the alkaline environment and favored hard tissue deposition.

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Section: Discussionsupporting

confidence: 75%

Impact of Immersion Media on Physical Properties and Bioactivity of Epoxy Resin-Based and Bioceramic Endodontic Sealers

et al. 2022

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“…Complete root canal filling using a biocompatible and dimensionally stable material is essential in achieving successful endodontic treatment [ 50 ]. At the same time, it has been observed and unanimously accepted that a complete hermetic seal of the three-dimensional endodontic space is impossible to achieve with the current materials and using current techniques; therefore, further clinical or in vitro studies should continue to assess the seal ability of endodontic materials [ 53 , 54 ]. As demonstrated, micro-leakage in the root canal filling is considered the single most important risk factor responsible for apical periodontitis [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Assessing the Sealing Performance and Clinical Outcomes of Endodontic Treatment in Patients with Chronic Apical Periodontitis Using Epoxy Resin and Calcium Salicylate Seals

et al. 2023

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Background and Objectives: Recognizing the significance of a hermetic apical seal for successful root canal treatment, the present investigation aimed to evaluate two sealing materials through an in vitro analysis, as well as to ascertain the clinical outcomes of patients treated with these two sealers in an in vivo setting. Materials and Methods: For the in vitro part of the study, two control groups of thirty monoradicular teeth were obturated with two sealers. Then, the sealers’ performance was tested based on a predefined protocol. Group A included 30 patients treated with an epoxy oligomer resin-based sealer (Adseal, MetaBiomed), while Group S comprised 30 patients treated with a polymeric calcium salicylate-based sealer (Sealapex, Kerr). Samples were sectioned and evaluated under the microscope to determine the sealer’s tightness by measuring the dye penetration into the root canal filling. For the in vivo part, a prospective study was designed to include 60 patients with chronic apical periodontitis in two endodontic treatment groups, using the same two sealers. Results: The in vitro analysis found that dye penetration in Group A was 0.82 mm (±0.428), while in Group S, the dye penetration was statistically significantly deeper, being 1.23 mm (±0.353). In the in vivo part of the study, the periapical index (PAI) significantly decreased 6 months after endodontic treatment, with 80.0% of patients in Group A having a PAI score of 2 compared to only 56.7% in Group S (p-value = 0.018). Similarly, tooth mobility scores significantly decreased after treatment, but with no difference between groups. The marginal bone loss decreased significantly more in the Adseal group compared to the Sealapex group (23.3% vs. 50.0%, p-value = 0.032). At the same time, 40.0% of patients in Group S had failed tooth healing compared to only 13.3% in Group A (p-value = 0.048). Conclusions: The in vitro study showed that Adseal had a better sealing capacity and a lower degree of dye penetration compared to Sealapex. However, on clinical evaluation in the in vivo study, both patient groups exhibited significant improvements in periapical index, tooth mobility scores, and pain reduction following endodontic treatment. Nevertheless, patients treated with Adseal showed a significantly greater improvement in PAI values, tooth mobility, and teeth healing after treatment. Overall, Adseal, as an endodontic sealer, may provide better sealing capabilities and enhanced clinical outcomes in the treatment of chronic apical periodontitis.

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“…Furthermore, there is a consensus among the literatures that nHA could enhance in vitro apatite-forming ability of pristine endodontic sealers [ 136 – 138 ]. Apart from nHA, nanostructured bioactive glass or bioglass (nBAG), an amorphous silicate-based compound, also has exhibited excellent capability to induce apatite formation and osteogenic differentiation [ 139 – 141 ]; moreover, the sealing ability of certain endodontic sealer could be promoted by fluoridated nBAG [ 142 ]. However, previous data suggested the inferiority of weak antibacterial effect of nHA and nBAG [ 140 , 143 , 144 ].…”

Section: Nanomaterials As Endodontic Sealersmentioning

confidence: 99%

Application of Nanomaterials in Endodontics

Afkhami,

Chen,

Walsh

et al. 2024

BME Front

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Recent advancements in nanotechnology have introduced a myriad of potential applications in dentistry, with nanomaterials playing an increasing role in endodontics. These nanomaterials exhibit distinctive mechanical and chemical properties, rendering them suitable for various dental applications in endodontics, including obturating materials, sealers, retro-filling agents, and root-repair materials. Certain nanomaterials demonstrate versatile functionalities in endodontics, such as antimicrobial properties that bolster the eradication of bacteria within root canals during endodontic procedures. Moreover, they offer promise in drug delivery, facilitating targeted and controlled release of therapeutic agents to enhance tissue regeneration and repair, which can be used for endodontic tissue repair or regeneration. This review outlines the diverse applications of nanomaterials in endodontics, encompassing endodontic medicaments, irrigants, obturating materials, sealers, retro-filling agents, root-repair materials, as well as pulpal repair and regeneration. The integration of nanomaterials into endodontics stands poised to revolutionize treatment methodologies, presenting substantial potential advancements in the field. Our review aims to provide guidance for the effective translation of nanotechnologies into endodontic practice, serving as an invaluable resource for researchers, clinicians, and professionals in the fields of materials science and dentistry.

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Structural, fluoride release, and 3D interfacial adhesion analysis of bioactive endodontic sealers

Cited by 11 publications

References 26 publications

Impact of Immersion Media on Physical Properties and Bioactivity of Epoxy Resin-Based and Bioceramic Endodontic Sealers

Impact of Immersion Media on Physical Properties and Bioactivity of Epoxy Resin-Based and Bioceramic Endodontic Sealers

Assessing the Sealing Performance and Clinical Outcomes of Endodontic Treatment in Patients with Chronic Apical Periodontitis Using Epoxy Resin and Calcium Salicylate Seals

Application of Nanomaterials in Endodontics

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