Structural, functional and therapeutic biology of survivin

Sah, Nand K.; Khan, Zakir; Khan, Ghulam Jilany; Bisen, Prakash S.

doi:10.1016/j.canlet.2006.03.007

Cited by 328 publications

(243 citation statements)

References 43 publications

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“…Survivin plays an important role in the suppression of apoptosis by either directly or indirectly inhibiting caspase activity, and may be found in cells showing proliferative activity, such as epithelial basal cells. Great amounts of survivin are expressed in the G2/M phase, but very little expression is observed in the G1/S phase [15][16][17]. The expression of survivin in odontogenic epithelial cells has already been described and may be associated with changes in cell cycle caused by the pathogenesis of some lesions [18,19].…”

Section: Introductionmentioning

confidence: 95%

Odontogenic Epithelium: Immunolabeling of Ki-67, EGFR and Survivin in Pericoronal Follicles, Dentigerous Cysts and Keratocystic Odontogenic Tumors

Oliveira

Lauxen

Chaves

et al. 2010

Head and Neck Pathol

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Section: Introductionmentioning

confidence: 95%

Odontogenic Epithelium: Immunolabeling of Ki-67, EGFR and Survivin in Pericoronal Follicles, Dentigerous Cysts and Keratocystic Odontogenic Tumors

Oliveira

Lauxen

Chaves

et al. 2010

Head and Neck Pathol

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“…In normal adult tissues survivin is usually undetectable, however it is overexpressed in the majority of human tumors, including lung, colon, breast, stomach and liver cancer (4)(5)(6)(7)(8)(9). Due to its involvement in tumorigenesis, survivin has been proposed as a prognostic marker and a molecular target for anticancer therapies (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

“…Survivin shuttles between the nucleus and cytoplasm, and several studies have demonstrated that chromosomal regional maintenance protein-1 (CRM-1) regulates its subcellular distribution (2,3,12,13). CRM-1, a member of the importin B superfamily, exports both proteins and mRNAs from the nucleus and is the main nuclear exporter in humans.…”

Section: Introductionmentioning

confidence: 99%

Expression of chromosomal regional maintenance protein-1 may be associated with subcellular survivin expression in human gastric and colorectal carcinoma

et al. 2016

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Abstract. Survivin, a member of the inhibitor of apoptosis protein family, is a potential prognostic marker and molecular target for anticancer therapies. Chromosomal regional maintenance protein-1 (CRM-1) mediates the nuclear export of proteins such as survivin. The aims of the present study were to compare the expression and subcellular localization of CRM-1 in human gastric and colorectal carcinomas and to assess the association between CRM-1 and survivin expression in these tumor types. The nuclear and cytoplasmic CRM-1 expression rates in gastric carcinoma were 61% (42/69) and 29% (20/69), respectively, while the nuclear and cytoplasmic CRM-1 expression rates in colorectal carcinoma were 55% (43/78) and 37% (29/78), respectively. Nuclear and cytoplasmic CRM-1 expression was found to be significantly correlated with nuclear and cytoplasmic survivin expression in colorectal carcinoma, but not gastric carcinoma. These results indicate that CRM-1 expression patterns differ between gastric and colorectal carcinomas and thus, we hypothesize that CRM-1-mediated nuclear export of survivin may be deregulated in gastric carcinoma. Therefore, CRM-1 may exhibit different functions in gastric and colorectal carcinoma.

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“…However, recent evidence has indicated that svv is also expressed in normal tissues, suggesting a protective role against various stresses (Johnson et al 2005;Fukuda and Pelus 2006;Kindt et al 2008). Furthermore, svv inhibits Caspase activity to block apoptosis (Sah et al 2006). It has been demonstrated that svv is a member of the chromosomal passenger complex (CPC) proteins and interacts with Aurora-B kinase, Borealin and inner centromere protein (INCENP) to play a significant role in cell division (Lens et al 2006;Ruchaud et al 2007).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, a recent finding led to the hypothesis that svv plays a novel role in the enucleation of erythroblasts (Keerthivasan et al 2012). Future prospective studies should focus on svv as a useful prognostic marker (Sah et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Functional analysis of a survivin-like gene in Bombyx mori

Tang

Wu³

et al. 2013

Cytotechnology

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The survivin (svv) gene is a newly discovered member of the inhibitors of apoptosis gene family. In recent years, svv has been confirmed to have an anti-apoptosis function and to play a critical role in cell division. We identified a survivin-like gene in the silkworm, Bombyx mori (Bm-svv). In this study, to gain insight into its function, a baculovirus expression system was used to express the Bm-svv gene in insect cell lines. The recombinant viruses were then used as a vector to transform insect cells, and cell activity was determined using the Cell Counting Kit-8 (CCK-8), which is usually employed for detecting mammalian cell number. The results indicated that the Bm-svv gene plays a role in the cell growth arrest or apoptosis induced by viruses. Furthermore, the CCK-8 kit is effective in determining the activity of insect cells.

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Structural, functional and therapeutic biology of survivin

Cited by 328 publications

References 43 publications

Odontogenic Epithelium: Immunolabeling of Ki-67, EGFR and Survivin in Pericoronal Follicles, Dentigerous Cysts and Keratocystic Odontogenic Tumors

Odontogenic Epithelium: Immunolabeling of Ki-67, EGFR and Survivin in Pericoronal Follicles, Dentigerous Cysts and Keratocystic Odontogenic Tumors

Expression of chromosomal regional maintenance protein-1 may be associated with subcellular survivin expression in human gastric and colorectal carcinoma

Functional analysis of a survivin-like gene in Bombyx mori

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