Structural identification of ginseng polysaccharides and testing of their antioxidant activities

Luo, Dianhui; Fang, Baishan

doi:10.1016/j.carbpol.2007.09.006

Cited by 166 publications

(95 citation statements)

References 16 publications

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“…Gas chromatography mass spectrometry (GC-MS) examination was performed on a Trace GC2010/Trace MS chromatograph. The 1 H and 13 C nuclear magnetic resonance (NMR) spectra were recorded in D 2 O on a Bruker Avance DPX-400 instrument. The electrospray ionization mass spectrometry (ESI-MS) analysis of oligosaccharide fractions were performed on a VG Quattro MS/MS spectrometer as described in [16,17].…”

Section: Methodsmentioning

confidence: 99%

“…In the food industry, pectic polysaccharides are used as thickener, stabilizer, gelling agent, emulsifier, flavour fixation agent and texture modifier [1,11,12]. Pectic polysaccharides are widely studied due to their bioactivities and applications, such as pectin from Panax ginseng [13], Centella asiatica [4] and Diospyros kaki Thumb [14], etc. Dendrobium nobile Lindl.…”

Section: Introductionmentioning

confidence: 99%

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Structure elucidation of a pectin fromDendrobium nobileLindl. and its immunological activity

Wang

Zhang

Luo

2018

Biotechnology & Biotechnological Equipment

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In this study, an RG-I pectin DNP-W6 was isolated from the stems of Dendrobium nobile Lindl. (Orchidaceae). It contained mannose, glucose, galactose, galacturonic acid and rhamnose in a molar ratio of 0.6: 1.0: 1.5: 1.1: 1.0. Its structural features were revealed by chemical, physical and spectral analysis. The results suggested that DNP-W6 possessed a backbone of a disaccharide of !4)-a-GalAp-(1!2)-a-Rhap-(1!, with approximate 50% substitution at O-4 of the rhamnopyranosyl residues. The side chains were neutral chains including galactosyl, mannosyl and glucosyl chains. The acetyl content was estimated to be 8.9%. The immunological results indicated that DNP-W6 and its derivatives exhibited different immunological activities in vitro, showing that the side chains and acetyl groups had an important effect on the expression of immunological activities.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structure elucidation of a pectin fromDendrobium nobileLindl. and its immunological activity

Wang

Zhang

Luo

2018

Biotechnology & Biotechnological Equipment

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“…Meyer (ginseng) is a medicinal plant with a wide range of therapeutic benefits and has many active chemical components, such as ginsenosides, ginseng polysaccharides and ginseng peptides (12,13). Ginsenoside Rb1 is the main neuroprotective molecule of ginseng.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effects of ginseng pectin through the activation of ERK/MAPK and Akt survival signaling pathways

et al. 2012

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Abstract. In this study, we investigated the neuroprotective activities of ginseng pectin (GP) against hydrogen peroxide (H 2 O 2 )-induced neuronal toxicity in different neuronal cells. GP selectively attenuated H 2 O 2 -induced damage up to 26% in primary cortical neuron cells and human glioblastoma U87 cells. Following H 2 O 2 exposure, DAPI staining and neuron-specific β-tubulin antibody probing indicated that GP maintained cell integrity and decreased nuclei condensation. Data from western blot analysis revealed that pre-treatment with GP increased the phosphorylation of both the extracellular signal-regulated kinases 1 and 2 (ERK1/2) and Akt in cortical neuron cells. However, the phosphorylation of ERK1/2 was increased, but that of Akt was decreased in U87 cells. These results suggest that the protective effects of GP against H 2 O 2 -induced apoptosis may be due to the activation of the phosphorylation of ERK1/2 and Akt; however, the mechanisms involved differ depending on the cell line. This neuroprotective property indicates that GP could serve as a potential therapeutic agent for neurodegenerative diseases.

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“…Polysaccharides from plant sources with immunomodulatory, anti-tumor, anti-viral, anti-bacterial, anti-inflammatory, anti-oxidant, and anti-diabetogenic activities have been reported [2,[9][10][11][12][13][14][15]. And a few polysaccharides, including lentinan, Astragalus polysaccharide, polyporus polysaccharide and Achyranthes bidentata polysaccharide have been licensed for clinical application in China [16].…”

Section: Discussionmentioning

confidence: 99%

Bioactive Polysaccharides of American Ginseng Panax quinquefolius L. in Modulation of Immune Function: Phytochemical and Pharmacological Characterization

Lui¹,

Chike²,

Jose³

et al. 2012

The Complex World of Polysaccharides

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Structural identification of ginseng polysaccharides and testing of their antioxidant activities

Cited by 166 publications

References 16 publications

Structure elucidation of a pectin fromDendrobium nobileLindl. and its immunological activity

Structure elucidation of a pectin fromDendrobium nobileLindl. and its immunological activity

Neuroprotective effects of ginseng pectin through the activation of ERK/MAPK and Akt survival signaling pathways

Bioactive Polysaccharides of American Ginseng Panax quinquefolius L. in Modulation of Immune Function: Phytochemical and Pharmacological Characterization

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