Structural Investigation of Epididymal Microvasculature and Its Relation to Telocytes and Immune Cells in Camel

Hussein, Manal T; Abdel-Maksoud, Fatma M.

doi:10.1017/s1431927620001786

Cited by 20 publications

(18 citation statements)

References 53 publications

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“…This anticipates a TC coordination for the lung resident immune cells to create the required appropriate milieu for efficient gas exchange. Similar cellular junctions between TCs and immune cells have been described in the epididymis of the dromedary camel (Hussein & Abdel-Maksoud, 2020). They suggested the participation of DCs and TCs in angiogenesis and a potential role for the interstitial elements in establishing a suitable environment for the optimum sperm maturation.…”

Section: T-and B-lymphocytessupporting

confidence: 54%

Pulmonary Guardians and Special Regulatory Devices in the Lung of Nile Monitor Lizard (Varanus niloticus) with Special Attention to the Communication Between Telocyte, Pericyte, and Immune Cells

Mohamedien

Awad

2021

Microsc Microanal

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Monitor lizards are acclimatized to a variety of environments. Most of the monitor species are terrestrial, although there are arboreal and semiaquatic monitors. Such accommodation requires unique cellular structure and regulatory devices in various organs, particularly their lungs. This study aimed to report the pulmonary guardians and special regulatory devices that may guard and promote the function of the lungs of the Nile monitor lizards (Varanus niloticus). Specially structured vessels were recorded in the pulmonary tissue involving atypical glomus vessels, vessels with variable wall thickness, and a venule with specialized internal elastic membrane. Moreover, numerous lung resident guardians could be identified including both alveolar and interstitial macrophages, dendritic cells, mast cells, and B- and T-lymphocytes. Pericytes were demonstrated surrounding the capillary endothelium with a characteristic direct hetero-cellular junction with telocytes. Telocytes established a microenvironment through an indirect hetero-cellular junction with the interstitial macrophage, dendritic cells, and pneumocyte type II. Collectively, these data indicate a significant role played by the specially structured vessels and the resident immune cells in guarding the pulmonary tissue of the Nile monitor lizards and promoting its function. Telocytes are suggested to play a key role in angiogenesis and cellular communication to promote the function of the immune cells.

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Section: T-and B-lymphocytessupporting

confidence: 54%

Pulmonary Guardians and Special Regulatory Devices in the Lung of Nile Monitor Lizard (Varanus niloticus) with Special Attention to the Communication Between Telocyte, Pericyte, and Immune Cells

Mohamedien

Awad

2021

Microsc Microanal

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“…Telocytes are present in the epididymis, occupying regions of the interstitium; they are positive for vascular endothelial growth factor, which may indicate that they have a role in angiogenesis. Moreover, telocytes in the epididymis establish cellular junctions with lymphocytes and dendritic cells, which may indicate that they have a role in the immune function (Hussein & Abdel-Maksoud, 2020).…”

Section: Epididymismentioning

confidence: 99%

Telocytes of the male urogenital system: Interrelationships, possible functions, and pathological implications

Sanches

Tamarindo

Maldarine

et al. 2021

Cell Biology International

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The male urogenital system is composed of the reproductive system and the urinary tract; they have an interconnected embryonic development and share one of their anatomical components, the urethra. This system has a highly complex physiology deeply interconnected with the circulatory and nervous systems, as well as being capable of adapting to environmental variations; it also undergoes changes with aging and, in the case of the reproductive system, with seasonality.The stroma is an essential component in this physiological plasticity and its complexity has increased with the description in the last decade of a new cell type, the telocyte. Several studies have demonstrated the presence of telocytes in the organs of the male urogenital system and other systems; however, their exact function is not yet known. The present review addresses current knowledge about telocytes in the urogenital system in terms of their locations, interrelationships, possible functions and pathological implications. It has been found that telocytes in the urogenital system possibly have a leading role in stromal tissue organization/maintenance, in addition to participation in stem cell niches and an association with the immune system, as well as specific functions in the urogenital system, lipid synthesis in the testes, erythropoiesis in the kidneys and the micturition reflex in the bladder. There is also evidence that telocytes are involved in pathologies in the kidneys, urethra, bladder, prostate, and testes.

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“…Moreover, our observation revealed that telocytes surrounded the epithelial cell clusters. Previously, the ultrastructure of telocytes was demonstrated clearly as stromal cells 31 , 33 – 35 . Telocytes, blood vessels, nerve ending, and limbal epithelial stem cells were isolated in clusters.…”

Section: Discussionmentioning

confidence: 99%

Novel detection of stem cell niche within the stroma of limbus in the rabbit during postnatal development

Abdellah

Desoky

2022

Sci Rep

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Identifying and locating stem cell populations in the limbus may lead to developing a cell-based strategy for treating the corneal injury. Therefore, this study was the first to design a follow-up on the microscopical and histomorphometric changes in the rabbit limbus and to localize and demonstrate the limbal stem cell niche during postnatal development. The paraffin sections from the eyes of different postnatal-developmental stages were stained and examined using light microscopy. Furthermore, sections were immunohistologically stained for the epithelial stem cell differentiation marker, cytokeratin-14. Moreover, semithin and ultrathin sections were applied for ultrastructural demonstration of the stem cell niche. This study revealed that the number and thickness of limbal epithelial layers increased with age, whereas the thickness of limbal stroma decreased. Additionally, the immunohistochemical data showed that ck14 staining intensity increased in the limbal region where limbal stem cells reside. The semithin and ultrastructure investigation revealed stem cell clusters within the limbus’s underlying stroma close to the blood and nerve supply and surrounded by telocytes. Conclusively, isolated clusters of limbal epithelial stem cells combined with blood vessels, nerve fibers, and telocytes propose a harmonious microenvironment of a stem cell niche.

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Structural Investigation of Epididymal Microvasculature and Its Relation to Telocytes and Immune Cells in Camel

Cited by 20 publications

References 53 publications

Pulmonary Guardians and Special Regulatory Devices in the Lung of Nile Monitor Lizard (Varanus niloticus) with Special Attention to the Communication Between Telocyte, Pericyte, and Immune Cells

Pulmonary Guardians and Special Regulatory Devices in the Lung of Nile Monitor Lizard (Varanus niloticus) with Special Attention to the Communication Between Telocyte, Pericyte, and Immune Cells

Telocytes of the male urogenital system: Interrelationships, possible functions, and pathological implications

Novel detection of stem cell niche within the stroma of limbus in the rabbit during postnatal development

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