Structural models for the interaction of Cd(II) with DNA: trans-[Cd(9-RGH-N7)2(H2O)4]2+

Ochoa, Pilar; Rodríguez-Tapiador, Maria Isabel; Alexandre, Simone S.; Pastor, César J.; Zamora, Félix

doi:10.1016/j.jinorgbio.2005.04.014

Cited by 28 publications

(10 citation statements)

References 40 publications

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“…Zinc-containing compounds are useful model compounds for biochemical research, as zinc(II) plays an important role in several zinc-containing metal enzymes such as zinc peptidases [20], human carbonic anhydrase [21], and alkaline phosphatase [22]. Though Cd(II) is a toxic metal [23], complexes have potential applications in catalysis [24], optical properties evolution [25], clathration [26], the vulcanization of diene rubbers [27], and in the treatment of hyperthyroidism [28]. Ag(I) ions are more attuned with biological system [29], with complexes exhibiting diverse coordination geometries as well as antimicrobial, antifungal, and anticancer activities [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, structural investigation, and antimicrobial studies of mononuclear Zn(II), Cd(II), and Ag(I) complexes of an N₃O Schiff base

Pal¹,

Banerjee²,

Bhadra³

et al. 2014

Journal of Coordination Chemistry

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L O N Ph Ph N C H N ZnBr2 RT CdI2 RT A Zn(II), Cd(II) and Ag(I) mononuclear complexes of an N 3 O Schiff base have been synthesized. The crystal structures of these complexes have been determined. The complexes have antibacterial activity against the bacteria K. pneumoniae 114, E. coli K88, S. typhi ATCC 34, B. subtilis UC564, and S. aureus ATCC25923 and antifungal activity against A. niger, A. oryzae, P. notatum, and S. cerevisiae. An N 3 O Schiff base (L), 1 : 1 condensate of benzil monohydrazone and 4-pyridine carboxaldehyde, and its Zn(II), Cd(II), and Ag(I) complexes were synthesized and characterized by elemental analyses and various spectroscopic techniques. The crystal structures of [ZnL 2 Br 2 ] (1), [CdL 2 I 2 ]·CH 2 Cl 2 ,(2)·CH 2 Cl 2 , and [Ag(L) 2 ]ClO 4 (3) have been determined using X-ray crystallography. The Zn(II) and Cd(II) complexes show a tetrahedral configuration whereas in the asymmetric unit of 3, two independent coordination units of Ag(I) are present. Carbonyl-silver interaction, weak C-H⋯O interaction, and also π-π interaction are present in 3 in the solid state. The synthesized complexes have antibacterial activity against Klebsiella pneumoniae 114, Escherichia coli K88, Salmonella typhi ATCC 34, Bacillus subtilis UC564, and Staphylococcus aureus ATCC25923. The results showed that in some cases the antibacterial activities of the complexes were comparable to standard antibiotics Tetracycline and Streptomycin. The antifungal activities of the complexes were also studied for Aspergillus niger, Aspergillus oryzae, Penicillium notatum, and Saccharomyces cerevisiae. MIC values of 1, 2·CH 2 Cl 2 , and 3 are less than the Nystatin standard.

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, structural investigation, and antimicrobial studies of mononuclear Zn(II), Cd(II), and Ag(I) complexes of an N₃O Schiff base

Pal¹,

Banerjee²,

Bhadra³

et al. 2014

Journal of Coordination Chemistry

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“…Even at very low concentrations cadmium ion also can cause extensive damage to kidney, liver, lungs, prostates and hematopoietic systems of human, so it has been accepted by the International Agency for Research on Cancer as a category carcinogen. 1,2 Recent studies suggest that cadmium-induced carcinogenicity involve direct or indirect interaction of cadmium with DNA because DNA offers many binding sites for cadmium, [3][4][5][6] although the exact molecular mechanism of cadmium-induced carcinogeniciy remains largely unclear. Indeed, it has been reported that Cd(II) ion can react with nucleobases, nucleic metallothionein and plasmid DNA causing extensive damage to these targets.…”

Section: Introductionmentioning

confidence: 99%

Studies on the Interaction of Dinitratobis(phen) Cadmium Complex with DNA

Yuan

Wei

et al. 2007

Chin. J. Chem.

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DNA-binding properties of the dinitratobis(phen) cadmium complex [Cd(phen) 2 (NO 3 ) 2 ] (where phen ＝ 1,10-phenanthroline) have been investigated with absorption titration, fluorescence spectroscopy, viscosity measurement, molecular modeling and density functional theory (DFT) calculations. The results indictate DNA-binding mode of the complex to be weak groove binding rather than partial intercalative interaction expected of the extended planar aromatic phen ring. In addition, the DNA cleavage study was carried out by gel electrophoresis experiment. The results showed that the complex both hardly cleaves pBR322 DNA in the absence and present ascorbate. So it is suggested that the formation of cadmium complex can decrease cadmium toxicity to some extents.

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“…The field of nucleic acid-metal ion interactions has thus came of age, as hallmarked, inter alia, by the recent publication of a book by Hud et al [71]. [68,69].…”

Section: Discussionmentioning

confidence: 99%

“…Zamora et al [69] have reported the first example of a guanineguanine cross-link for a Cd(II) complex. A large excess of Cd(NO 3 ) 2 was allowed to react with 9-ethyl-and 9-methylguanine in water at 80 °C to give complexes trans-[Cd II (L) 2 (OH 2 ) 4 ](NO 3 ) 2 ] [L = 9-methylguanine (128) and 9-ethylguanine (129), Scheme (20)].…”

Section: Zinc(ii) Copper(ii) and Cadmium(ii) Complexesmentioning

confidence: 99%

Transition Metal Ion Complexes of N-alkylguanines

Ferenc

Pádár

Szolomájer

et al. 2011

COC

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The family of cisplatin and its analogues contains some of the most powerful anticancer drugs developed to date and, since their discovery, extensive efforts have been devoted to understand their mode of action. 9-Alkylguanines have featured widely in these studies as model nucleobases. This review describes both the synthesis and the chemical, biological and miscellaneous spectroscopic properties of a variety of transition metal ion (Pt, Pd, Ru, Os, Rh, Re, Tc, Zn, Cu, Cd) complexes of N-alkylguanines (mostly 9-alkylguanines) which have been reported in the literature principally within the 2003-2008 period. Special attention has been given to the acid-base properties of these complexes, where coordination to transition metal ions usually leads to significant acidification of the guaninyl N1-H proton, and its consequences

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Structural models for the interaction of Cd(II) with DNA: trans-[Cd(9-RGH-N7)2(H2O)4]2+

Cited by 28 publications

References 40 publications

Synthesis, characterization, structural investigation, and antimicrobial studies of mononuclear Zn(II), Cd(II), and Ag(I) complexes of an N₃O Schiff base

Synthesis, characterization, structural investigation, and antimicrobial studies of mononuclear Zn(II), Cd(II), and Ag(I) complexes of an N₃O Schiff base

Studies on the Interaction of Dinitratobis(phen) Cadmium Complex with DNA

Transition Metal Ion Complexes of N-alkylguanines

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Structural models for the interaction of Cd(II) with DNA: trans-[Cd(9-RGH-N7)2(H2O)4]2+

Cited by 28 publications

References 40 publications

Synthesis, characterization, structural investigation, and antimicrobial studies of mononuclear Zn(II), Cd(II), and Ag(I) complexes of an N3O Schiff base

Synthesis, characterization, structural investigation, and antimicrobial studies of mononuclear Zn(II), Cd(II), and Ag(I) complexes of an N3O Schiff base

Studies on the Interaction of Dinitratobis(phen) Cadmium Complex with DNA

Transition Metal Ion Complexes of N-alkylguanines

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Product

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Synthesis, characterization, structural investigation, and antimicrobial studies of mononuclear Zn(II), Cd(II), and Ag(I) complexes of an N₃O Schiff base

Synthesis, characterization, structural investigation, and antimicrobial studies of mononuclear Zn(II), Cd(II), and Ag(I) complexes of an N₃O Schiff base