Structural MRI biomarkers of shared pathogenesis in autism spectrum disorder and epilepsy

Blackmon, Karen

doi:10.1016/j.yebeh.2015.02.017

Cited by 26 publications

(19 citation statements)

References 137 publications

(217 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Variation in the pathophysiology of non-ASD epilepsy is very similar to the variation in the pathophysiology of epilepsy in ASD (Amiet et al 2013;Blackmon 2015;Stafstrom and Carmant 2015). Some epilepsy is the result of malformations of cortical development (MCDs), including focal cortical dysplasia and heterotopias, and these malformations have been found in ASD (Blackmon 2015).…”

Section: Does Asd Have Neurobiological Validity?mentioning

confidence: 83%

“…Some epilepsy is the result of malformations of cortical development (MCDs), including focal cortical dysplasia and heterotopias, and these malformations have been found in ASD (Blackmon 2015).…”

Section: Does Asd Have Neurobiological Validity?mentioning

confidence: 99%

“…Although syndromic ASD has been estimated to account for only 5 to 25 % of all cases of ASD (Adviento et al 2014;de la Torre-Ubieta et al 2016;Jeste and Geschwind 2014), more forms of syndromic ASD continue to be identified (Adviento et al 2014;Richards et al 2015;Roullet et al 2013;Smile et al 2013;Yu and Berry-Kravis 2014;Yuen et al 2015). In addition, syndromic and idiopathic ASD brain impairments have been reported that are similar (Adviento et al 2014;Blackmon 2015;D'Angelo et al 2015;Guilmatre et al 2014;Klusek et al 2015;Sala et al 2015).…”

Section: Does Asd Have Neurobiological Validity?mentioning

confidence: 99%

See 2 more Smart Citations

ASD Validity

Waterhouse

London

Gillberg

2016

Rev J Autism Dev Disord

View full text Add to dashboard Cite

ASD research is at an important crossroads. The ASD diagnosis is important for assigning a child to early behavioral intervention and explaining a child's condition. But ASD research has not provided a diagnosis-specific medical treatment, or a consistent early predictor, or a unified life course. If the ASD diagnosis also lacks biological and construct validity, a shift away from studying ASD-defined samples would be warranted. Consequently, this paper reviews recent findings for the neurobiological validity of ASD, the construct validity of ASD diagnostic criteria, and the construct validity of ASD spectrum features. The findings reviewed indicate that the ASD diagnosis lacks biological and construct validity. The paper concludes with proposals for research going forward.Keywords DSM-5 . ASD . Autism . Diagnosis . Validity . Comorbidity . HeterogeneityThe goal of the DSM-3 nosology (American Psychiatric Association 1980) was to create reliable and standard categorical psychiatric diagnoses (Robins and Guze 1970). However, in the past 30 years, clinical, genetics, and neuroscience findings have revealed that the DSM diagnoses are not biologically valid. The National Institutes of Mental Health (NIMH) responded by proposing the Research Domain Criteria (RDoC) framework for a brain-based transdiagnostic psychiatric symptom nosology (Cuthbert and Insel 2013;Insel et al. 2010;Lilienfeld and Treadway 2016). Peterson (2015) and Weinberger et al. (2015) argued that the RDoC could not replace the DSM-5 psychiatric nosology (American Psychiatric Association 2013) or the parallel International Classification of Diseases (ICD) psychiatric nosology (World Health Organization 2012). But BFor the foreseeable future, RDoC is not envisioned as a system of psychiatric classification in its own right. Instead, in the near term, RDoC and DSM-ICD are expected to coexist. Nevertheless, RDoC is intended to provide scaffolding for a large-scale research program that will ultimately yield an alternative to DSM-ICD^ (Lilienfeld and Treadway 2016, p. 445).RDoC advocates accept that DSM-5/ICD psychiatric categories remain necessary in clinical practice, but argue that researchers should shift to RDoC study designs immediately. They assert that studying psychiatric categories lacking biological validity blocks the discovery of brain bases for psychopathology and thus cannot lead to effective medical treatments for specific psychiatric symptoms (Cuthbert and Insel 2013;Insel et al. 2010;Lilienfeld and Treadway 2016;Yee et al. 2015). Against this RDoC imperative for biological validity, Weinberger et al. (2015) countered that current DSM-5 psychiatric behavioral diagnoses were valid when they yielded effective medical treatment, clear prognosis, and a life course specific to a diagnosis.Autism spectrum disorder (ASD) research has been productive (Dawson 2016;de la Torre-Ubieta et al. 2016;Szatmari et al. 2016), but no ASD research findings have met the validity criteria of Weinberger et al. (2015). DSM-5 ASD research has found no s...

show abstract

Section: Does Asd Have Neurobiological Validity?mentioning

confidence: 83%

Section: Does Asd Have Neurobiological Validity?mentioning

confidence: 99%

Section: Does Asd Have Neurobiological Validity?mentioning

confidence: 99%

See 1 more Smart Citation

ASD Validity

Waterhouse

London

Gillberg

2016

Rev J Autism Dev Disord

View full text Add to dashboard Cite

show abstract

“…Abnormal gray and white matter volume distribution is common in autism [19]. It is likely that this disrupted development contributes to epileptic activity.…”

Section: Shared Biochemical Mechanismsmentioning

confidence: 99%

Pediatric Traumatic Brain Injury and Autism: Elucidating Shared Mechanisms

Singh

Turner

Nguyen

et al. 2016

Behavioural Neurology

View full text Add to dashboard Cite

Pediatric traumatic brain injury (TBI) and autism spectrum disorder (ASD) are two serious conditions that affect youth. Recent data, both preclinical and clinical, show that pediatric TBI and ASD share not only similar symptoms but also some of the same biologic mechanisms that cause these symptoms. Prominent symptoms for both disorders include gastrointestinal problems, learning difficulties, seizures, and sensory processing disruption. In this review, we highlight some of these shared mechanisms in order to discuss potential treatment options that might be applied for each condition. We discuss potential therapeutic and pharmacologic options as well as potential novel drug targets. Furthermore, we highlight advances in understanding of brain circuitry that is being propelled by improved imaging modalities. Going forward, advanced imaging will help in diagnosis and treatment planning strategies for pediatric patients. Lessons from each field can be applied to design better and more rigorous trials that can be used to improve guidelines for pediatric patients suffering from TBI or ASD.

show abstract

“…This survey presents applications of the sMRI, DTI, and fMRI to study the ASD (mostly, for the last two decades) in order to outline the most important findings with these modalities across all life stages. This provides a comprehensive study unlike the recent surveys that either focus on one modality, [33][34][35][36], or address a specific life stage, [35,37]. Moreover, this survey highlights the methodologies conducted in each study and categorizes them with respect to the approach (e.g.…”

Section: B Introductionmentioning

confidence: 99%

A CAD system for early diagnosis of autism using different imaging modalities.

Ismail¹

View full text Add to dashboard Cite

Structural MRI biomarkers of shared pathogenesis in autism spectrum disorder and epilepsy

Cited by 26 publications

References 137 publications

ASD Validity

ASD Validity

Pediatric Traumatic Brain Injury and Autism: Elucidating Shared Mechanisms

A CAD system for early diagnosis of autism using different imaging modalities.

Contact Info

Product

Resources

About