Structural optimization and in vivo evaluation of a colorectal stent with anti-migration and anti-tumor properties

Cai, Simin; Zhu, Jianguo; Zeng, Peng; Yang, Lingxin; Yan, Yunqi; Wang, Zhongmin; Shen, Yuanyuan; Guo, Shengrong

doi:10.1016/j.actbio.2022.10.040

Cited by 3 publications

(1 citation statement)

References 43 publications

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“…The aim of the colonoscopy is to detect cancerous polyps and remove them if they are found. Furthermore, this procedure is an examination that allows visualizing the entire large intestine and the final part of the small intestine (terminal ileum) [ 55 ].…”

Section: Experimentationmentioning

confidence: 99%

Methods for Gastrointestinal Endoscopy Quantification: A Focus on Hands and Fingers Kinematics

Otero-González

Caeiro-Rodríguez

Rodríguez-D’Jesús

2022

Sensors

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Gastrointestinal endoscopy is a complex procedure requiring the mastery of several competencies and skills. This procedure is in increasing demand, but there exist important management and ethical issues regarding the training of new endoscopists. Nowadays, this requires the direct involvement of real patients and a high chance of the endoscopists themselves suffering from musculoskeletal conditions. Colonoscopy quantification can be useful for improving these two issues. This paper reviews the literature regarding efforts to quantify gastrointestinal procedures and focuses on the capture of hand and finger kinematics. Current technologies to support the capture of data from hand and finger movements are analyzed and tested, considering smart gloves and vision-based solutions. Manus VR Prime II and Stretch Sense MoCap reveal the main problems with smart gloves related to the adaptation of the gloves to different hand sizes and comfortability. Regarding vision-based solutions, Vero Vicon cameras show the main problem in gastrointestinal procedure scenarios: occlusion. In both cases, calibration and data interoperability are also key issues that limit possible applications. In conclusion, new advances are needed to quantify hand and finger kinematics in an appropriate way to support further developments.

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Section: Experimentationmentioning

confidence: 99%

Methods for Gastrointestinal Endoscopy Quantification: A Focus on Hands and Fingers Kinematics

Otero-González

Caeiro-Rodríguez

Rodríguez-D’Jesús

2022

Sensors

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Recent advances of implantable systems and devices in cancer therapy and sensing

et al. 2023

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Lesion-Adaptative Bionic Tracheal Stent with Local Paclitaxel Release for Enhanced Therapy of Tracheal Tumor and Stenosis

Jin,

Fu,

Zhang

et al. 2024

ACS Biomater. Sci. Eng.

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The efficacy of tracheal stents (TSs) in treating malignant tracheal stenosis is often compromised by tumor overgrowth, leading to restenosis and other stent-related complications that conventional chemotherapy and commercial stents fail to adequately address. Drug-loaded tracheal stents have the potential to deliver chemotherapeutics directly to tumors while relieving stenosis, but their effectiveness has yet to be studied in vivo. The design of drug-loaded tracheal stents adapting to lesions to achieve optimal antitumor effects and minimal side effects remains an area worth exploring. In this study, a lesion-adaptive bionic tracheal stent (PTX-TS) designed for the dual purpose of treating tracheal tumors and associated stenosis was developed. This novel PTX-TS was evaluated using an orthotopic rabbit model of malignant tracheal stenosis, newly established in this study. The rabbit lesions were precisely scanned using computed tomography (CT) for 3D reconstruction, enabling the design of a PTX-TS that fit both the tumor and airway dimensions to ensure complete tumor coverage and effective dilation of the stenotic airway. The PTX-TS featured a bilayer structure including a surface layer of PTX/ethylene-vinyl acetate copolymer (EVA) blends for sustained PTX release and an inner layer of polycaprolactone (PCL)/EVA blends for appropriate mechanical performance. The stent was fabricated layer by layer using a custom-built 3D printer, and the drug-loaded surface layer was printed using a novel liquid printing technique developed in our lab, achieving a high drug loading of up to 80%. The dose of the PTX-TS was investigated and set as 7.5 mg/cm 2 , which leads to maximum tissue permeation. With its bionic cross-sectional C-shaped structure, the PTX-TS demonstrated excellent radial flexibility, allowing successful implantation at the lesion site using a specially designed delivery apparatus, where it selfexpanded to relieve stenosis. Additionally, the PTX-TS effectively delivered PTX directly to the tracheal tumor, resulting in superior antitumor efficacy without significant toxicity or complications.

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Structural optimization and in vivo evaluation of a colorectal stent with anti-migration and anti-tumor properties

Cited by 3 publications

References 43 publications

Methods for Gastrointestinal Endoscopy Quantification: A Focus on Hands and Fingers Kinematics

Methods for Gastrointestinal Endoscopy Quantification: A Focus on Hands and Fingers Kinematics

Recent advances of implantable systems and devices in cancer therapy and sensing

Lesion-Adaptative Bionic Tracheal Stent with Local Paclitaxel Release for Enhanced Therapy of Tracheal Tumor and Stenosis

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