Abstract. We report a new investigation into how surface topography and friction affect human touch-feel perception. In contrast with previous work based on micro-scale mapping of surface mechanical and tribological properties, this investigation focuses on the direct measurement of the friction generated when a fingertip is stroked on a test specimen. A special friction apparatus was built for the in-situ testing, based on a linear flexure mechanism with both contact force and frictional force measured simultaneously. Ten specimens, already independently assessed in a 'perception clinic', with materials including natural wood, leather, engineered plastics and metal were tested and the results compared with the perceived rankings. Because surface geometrical features are suspected to play a significant role in perception, a second set of samples, all of one material were prepared and tested in order to minimise the influence of properties such as hardness and thermal conductivity. To minimise subjective effects, all specimens were also tested in a roller-on-block configuration based upon the same friction apparatus, with the roller materials being steel, brass and rubber. This paper reports the detailed design and instrumentation of the friction apparatus, the experimental set up and the friction test results. Attempts have been made to correlate the measured properties and the perceived feelings for both roughness and friction. The results show that the measured roughness and friction coefficient both have a strong correlation with the rough-smooth and grippy-slippery feelings.

Hepatitis B virus (HBV) infection is still one of the most dangerous viral illnesses. HBV infects around 257 million individuals worldwide. Hepatitis B in many individuals ultimately develops hepatocellular carcinoma (HCC), which is the sixth most common cancer and the third leading cause of cancer-related deaths worldwide. The innate immunity acts as the first line of defense against HBV infection through activating antiviral genes. Along with the immune responses, pro-inflammatory cytokines are triggered to enhance the antiviral responses, but this may result in acute or chronic liver inflammation, especially when the clearance of virus is unsuccessful. To a degree, the host innate immune and inflammatory responses dominate the HBV infection and liver pathogenesis. Thus, it is crucial to figure out the signaling pathways involved in the activation of antiviral factors and inflammatory cytokines. Here, we review the interplay between HBV and the signal pathways that mediates innate immune responses and inflammation. In addition, we summarize current therapeutic strategies for HBV infection via modulating innate immunity or inflammation. Characterizing the mechanisms that underlie these HBV-host interplays might provide new approaches for the cure of chronic HBV infection.

In nature, insects and plants have evolved ways of living and reproducing themselves using the least amount of resource. This involves both efficiency in metabolism and optimal mechanisms and materials for life functions. Human beings have long tried to learn from and mimic nature. The study of biological materials has received increasing interest in recent years due to the often extraordinary mechanical properties and unusual structures exhibited by these materials. Micro-structure biomaterials exhibit important local variations of elasticity due to the complex and anisotropic composition. In this paper, a specially developed multi-function tribological probe microscope (TPM) has been used to map the mechanical properties of some special micro-structured biomaterials. Results of the mapped surface topography and elastic modulus on specimens of elytra cuticle of dung beetle, nacre of shell and bovine horn have shown some significant lateral variations of elasticity across the surface area.

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