Structural organization of subgemmal neurogenous plaques in foliate papillae of tongue

Subgemmal neurogenous plaque associated with burning tongue: report of two cases and review of the literature

“…Occasional ganglion cells within nerve fascicles were NSE, NP and CD56 positive. Neuromatous stroma containing these cells was not observed, excluding the diagnosis of ganglioneuroma or ganglioneurofibroma 9 .…”

“…Subgemmal neurogenous plaques (SNPs) are microscopically characterized as subepithelial aggregates of ganglion cells and nerve plexus usually associated with taste buds of the tongue. Normally no clinical sign is observed, but occasionally this entity is associated with an erythematous area, ulcer, a white patch and a hyperplastic papule 4,9,10 . Oral burning symptoms have been associated with various possible etiologies, including fungal infections, vitamin deficiencies, drug side effects, oral allergies, hormonal disturbances, psychosocial stressors, diabetes, dry mouth, galvanism, parafunctional habits, cranial nerve injuries and also idiopathic causes 5 .…”

Double reporting and second opinion in head and neck pathology

“…Enlarged dental follicles or the dental papilla of a supernumerary tooth are one of the most common cases referred with a provisional diagnosis of dentigerous cyst, odontogenic myxoma or odontogenic fibroma [20,21]. Additional examples include the misinterpretation of the juxtaoral organ of Chievitz and subgemmal neurogenous plaques or other features associated with lingual foliate papillae/tonsil [3,22]. Focal obstructive adenitis, a common feature in aging salivary glands, can be confused with intercalary duct lesions [23,24]; the squamous metaplastic ''feeder'' salivary duct in a mucous extravasation cyst (mucocele) can be misinterpreted; and transepithelial elimination of sequestrae, not unusual in osteomyelitis, oral oncology patients with osteoradionecrosis and patients on bisphosphonates, can cause consternation when seen by general pathologists.…”

Neither inadequacy of biopsy nor inaccuracy of reporting predict non-response to small-cell carcinoma chemotherapy

“…[1][2][3][4] Unfortunately, the use of only conventional haematoxylin and eosin staining to determine the incidence of venous invasion has yielded a wide range of results (10-90%). [1][2][3][4][5][6] In the July 2004 publication of the Journal of Clinical Pathology, Vass et al 7 showed that using an elastica stain considerably increased the sensitivity of identifying venous invasion in colorectal cancer. Their study was carried out in a university teaching hospital by a specialist in colorectal pathology, as opposed to the original reports, which were made by a large team of non-specialists.…”

“…5 This anatomical variation, when hypertrophic, may mimic neural tumours, but has received less attention. It is a small (,3.5 mm), non-encapsulated rectangular mass, exclusively juxtaposed with the epithelial undersurface of foliate papillae.…”