Subgemmal neurogenous plaque associated with burning tongue: report of two cases and review of the literature

Clinicopathological and immunohistochemical features of the oral lymphoepithelial cyst: A multicenter study

“…The posterior border of the tongue is also the preferred region of occurrence of subgemmal neurogenous plaque, which is an anatomic structure that can lead to discomfort, pain, and a burning sensation . However, the association between subgemmal neurogenous plaque and OLEC has been poorly explored, especially with regards to symptoms …”

“…4,5,8,14,15 The posterior border of the tongue is also the preferred region of occurrence of subgemmal neurogenous plaque, which is an anatomic structure that can lead to discomfort, pain, and a burning sensation. 9,16,17 However, the association between subgemmal neurogenous plaque and OLEC has been poorly explored, especially with regards to symptoms. 9,16 The aim of the present study was to perform a retrospective, collaborative study on the clinical, demographic, microscopic, and immunohistochemical characteristics of OLEC, providing the largest sample for which all such features have been evaluated.…”

Histomorphometric characterization of subgemmal neurogenous plaques

“…With regard to the nature of SNPs, some authors believe that they may be reactive neuronal dysplasias, 4 incidental findings, 1 or normal structures associated with taste buds. 2 Taking together the information acquired from these 28 cases and from previous cases reported in the literature, we could infer that SNPs may be considered normal structures that sometimes give rise to symptoms. 2,5 Although uncommon, symptoms, such as burning sensation and pain, may be associated with SNPs.…”

“…Associated clinical symptoms and signals, such as burning sensation, erythema, ulcers, white patches, and hyperplastic nodule, are uncommon. 2,3 Because the clinical and histopathologic features of SNPs can vary from patient to patient, their structure may represent a diagnostic challenge for clinicians and pathologists, 2 occasionally leading to misdiagnosis. 3,4 Only 2 other previous small case series describe the morphologic features of SNPs.…”

Neuroepithelial structures associated with neurogenous subgemmal plaque of the tongue: an autopsy finding

“…However, we could not identify the neuroepithelial structures in any of the nine cases reported. 2,3 An important line of investigation by our group refers to the study of the oral alterations found during autopsy in patients who had died due to complications of human immunodeficiency virus infection. 4,5 Although not a common field of study by oral pathologists, autopsybased investigations represent an unmeasured source of data for better understanding the oral manifestations of systemic diseases, especially in developing countries, where infections still represent major causes of death.…”