Neuroepithelial structures associated with neurogenous subgemmal plaque of the tongue: an autopsy finding

Fonseca, Felipe Paiva; Moreira, Johanna Pamela Latta; Almeida, Oslei Paes de; Vargas, Pablo Agustı́n; Mauad, Thaís

doi:10.1016/j.oooo.2015.02.487

Cited by 7 publications

(3 citation statements)

References 5 publications

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“…Additionally, these authors were struck by the fact that the set of epithelial nests in the SNP was similar, if not identical, to the anatomical structure of the JOOC. Other authors [ 13 , 14 , 15 ] adhered to this interpretation, and all of them considered that the collection of epithelial nests associated with the SNP was a persistent non-involuted JOOC of lingual location. Our group in 2006 reported a case of prominent PEH associated with two SNPs [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Some authors considered that the epithelial proliferation associated with the plaque was neural in character and suggested the term ‘neuroepithelial structure’ (NES) to designate it. In these cases, the presence of epithelial nests closely associated with the SNP was considered reminiscent of the juxtaoral organ of Chievitz (JOOC) [ 12 , 13 , 14 , 15 ]. Those authors postulated that the epithelial nests were remnants of embryological structures involved in tongue formation.…”

Section: Introductionmentioning

confidence: 99%

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Subgemmal neurogenous plaques of the tongue: a systematic autopsy study

Val‐Bernal

Garijo²,

Fontanil³

2022

Rom J Morphol Embryol

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There is no evaluation of the prevalence of this structure in the general population. We present a systematic study of samples obtained at random from the dorsal portion of the oral tongue in 205 consecutive complete autopsies. Each sample was about 15 mm long and 10 mm thick. Four hundred fifty-eight samples were routinely obtained and an average of 2.23±0.88 samples per case (range 1–7) was collected. The total number of SNPs observed was 556, with a mean of 2.71±2.68 per case (range 0–16). This means that for every 15 linear mm of the oral tongue, approximately 2.7 SNPs can be present. SNPs display several ages, and they do not show sex differences. The mean size of these structures was 2.1±0.94 mm (range 0.6–3.6 mm). SNP is characterized by its unique neural, zonal pattern with a superficial neurofibroma-like area and a deeper neuroma-like area. Special features of the SNPs include the presence of taste buds (49.1%), ganglion cells (26.3%), dilated thin-walled vessels (11.3%), salivary gland excretory ducts emptying on the surface of the papillae (6.1%), moderate-severe inflammatory infiltrate (6.8%), presence of lymphoid tissue in the vicinity (7.0%), and hyperplasia of the epithelial cover with pseudoepitheliomatous appearance (7.0%). The differential diagnoses include schwannoma, neurofibroma, ganglioneuroma, traumatic neuroma, mucosal neuroma, and squamous cell carcinoma. SNPs are small, normal structures that may undergo hyperplasia and are usually seen incidentally.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Subgemmal neurogenous plaques of the tongue: a systematic autopsy study

Val‐Bernal

Garijo²,

Fontanil³

2022

Rom J Morphol Embryol

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“…7 JOC is usually located in the buccotemporal space 8 ; however, there are cases described in other head and neck sites, such as the mandible and the maxilla. 9,10 Fonseca et al 11 reported a case of SNP associated with epithelial nests dispersed in connective tissue, showing no signs of atypia or mitotic figures. Although these structures are considered normal residual embryologic structures, pathologists should be aware of the existence of the JOC to avoid confusing SNPs with other lesions, such as SCC.…”

Section: Discussionmentioning

confidence: 99%

Histomorphometric characterization of subgemmal neurogenous plaques

Pellicioli

Fonseca

Silva

et al. 2017

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Subgemmal neurogenous plaque of the tongue: a report of three cases

Gonzaga

Moreira

Sena

et al. 2017

Oral Maxillofac Surg

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Subgemmal neurogenous plaque (SNP) is a biphasic neural structure associated with the taste buds. Clinically, SNP usually presents as an asymptomatic, normally colored, papule located in the posterior lateral border of the tongue. Accurate diagnosis is based only on histopathological examination, which shows a superficial neurofibroma-like pattern and a neuroma-like in the deep zone. Appropriate recognition of clinical and morphological aspects of SNPs can avoid their misdiagnosis as neural neoplasms. We report three cases of SNP with detailed clinical, histopathological, and immunohistochemical features.

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Neuroepithelial structures associated with neurogenous subgemmal plaque of the tongue: an autopsy finding

Cited by 7 publications

References 5 publications

Subgemmal neurogenous plaques of the tongue: a systematic autopsy study

Subgemmal neurogenous plaques of the tongue: a systematic autopsy study

Histomorphometric characterization of subgemmal neurogenous plaques

Subgemmal neurogenous plaque of the tongue: a report of three cases

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