Structural properties, bioactivities, structure-activity relationships and bio-applications of polysaccharides from Auricularia auricula: A review

Tang, Jun; He, Zihan; Zhang, Baohui; Cheng, Jingjing; Qiu, Wenxiu; Chen, Xinyan; Chang, Cong; Wang, Qi; Hu, Junjie; Cai, Chao; Meng, Yan

doi:10.1016/j.ijbiomac.2024.135941

International Journal of Biological Macromolecules

2024

DOI: 10.1016/j.ijbiomac.2024.135941

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Structural properties, bioactivities, structure-activity relationships and bio-applications of polysaccharides from Auricularia auricula: A review

Jun Tang,

Zihan He,

Baohui Zhang

et al.

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Cited by 2 publications

References 111 publications

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Isolation, structures, bioactivities, and applications of the polysaccharides from Boletus spp.: A review

Tian,

Zhang,

Shang

et al. 2025

International Journal of Biological Macromolecules

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Isolation, structures, bioactivities, and applications of the polysaccharides from Boletus spp.: A review

Tian,

Zhang,

Shang

et al. 2025

International Journal of Biological Macromolecules

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Structural Characterization and Hypoglycemic Activity of a Glycoprotein Extracted from Auricularia Auricula

Zhan,

Yang,

Zhao

et al. 2024

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Glycoproteins are special proteins and important nutrients for hypoglycemic activity. However, the structure of Auricularia Auricula glycoprotein (AAG) and the stability of its hypoglycemic activity during simulated digestion (including saliva, gastral and intestine digestion) in vitro are still unknown. In this study, AAG-3 was isolated from Auricularia Auricula. SDS-PAGE, UV spectrum, FTIR, amino acid composition, dichroic spectrum and SEM were used to characterize its structure. The hypoglycemic activity of AAG-3 during in vitro digestion was investigated via inhibition of α-amylase and α-glucosidase activities, as well as glucose consumption, glycogen content and related enzyme activity in insulin-resistant HepG2 cells. Structural characterization showed that AAG-3 with a Mw of 18.21 kDa had an O-type glycopeptide bond and typical functional groups of glycoproteins. AAG-3 contained 18 kinds of amino acid and many α-helixes and β-turns, and its microstructure was sheet-like. With the simulated digestion of AAG-3 in vitro, the inhibition of α-amylase and α-glucosidase activity as well as the glucose consumption, glycogen content and HK and PK enzyme activities in insulin-resistant HepG2 cells were significantly increased. Therefore, AAG-3 has a potential role in reducing blood glucose levels and improving insulin resistance and can be used as a potential micronutritional supplement for diabetic patients.

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Structural properties, bioactivities, structure-activity relationships and bio-applications of polysaccharides from Auricularia auricula: A review

Cited by 2 publications

References 111 publications

Isolation, structures, bioactivities, and applications of the polysaccharides from Boletus spp.: A review

Isolation, structures, bioactivities, and applications of the polysaccharides from Boletus spp.: A review

Structural Characterization and Hypoglycemic Activity of a Glycoprotein Extracted from Auricularia Auricula

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