Structural properties of the ZnO doped hydroxyapatite nanocomposite material

Martynyuk, O. O.; Sukhodub, L. F.; Meshkov, A. M.; Sukhodub, Leonid Fedorovych

doi:10.1109/nap.2016.7757308

Cited by 1 publication

(1 citation statement)

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“…Hence, no considerable weight loss was observed between 600–1000 °C, and the prepared HAp-ZnO composite material was calcined at 650 °C. Moreover, it has been reported that the deformation of the apatite structure with an increase in temperature (>900 °C) causes the lattice replacement of Ca ions with Zn ions [ 31 ]. Thus, the calcination process results in the formation of distinct phases of HAp and zinc oxide material, which was evident from the XRD data.…”

Section: Resultsmentioning

confidence: 99%

One-Pot Hydrothermal Preparation of Hydroxyapatite/Zinc Oxide Nanorod Nanocomposites and Their Cytotoxicity Evaluation against MG-63 Osteoblast-like Cells

et al. 2023

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In the present study, HAp-ZnO nanorod nanocomposites were successfully prepared using a customized hydrothermal reactor and studied for their compatibility against MG-63 osteoblast-like cells. The crystallinity, morphology, presence of chemical elements, and surface area properties were studied by XRD (X-ray diffraction), FE-SEM (field emission scanning electron microscopy), TEM (transmission electron microscopy), EDS (energy dispersive spectrum) and N2 adsorption/desorption isotherm techniques, respectively. Further, the mechanical strength and thermal analysis were carried out using the nanoindentation method and thermogravimetric/differential scanning calorimeter (TG/DSC) methods, respectively. Moreover, in vitro biocompatibility studies for the prepared samples were carried out against human osteosarcoma cell lines (MG-63). The crystalline nature of the samples without any impurity phases was notified from XRD results. The formation of composites with the morphology of nanorods and the presence of desired elements in the intended ratio were verified using FE-SEM and EDS spectra, respectively. The TG/DSC results revealed the improved thermal stability of the HAp matrix, promoted by the reinforcement of the ZnO nanorods. The nanoindentation study ensured a significant enhancement in the mechanical stability of the prepared composite material. Finally, it demonstrated that the HAp matrix’s mechanical strength and thermal stability were improved by the reinforcement of ZnO, and the cytotoxicity evaluation affirmed the biocompatible nature of the biomimetic hydroxyapatite in the composite.

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Section: Resultsmentioning

confidence: 99%