Structural Relationships Between Interstitial Cells of Cajal and Smooth Muscle Cells/Nerve Fibers in the Gastric Muscularis Mucosae of Chinese Giant Salamander

Yu, Hang; Liu, Yangquan; Chu, Meng; Si, Yu; Ye, Yaqiong; Ge, Tingting; Zhao, Haixia; Hui, Zhang

doi:10.1017/s1431927620024861

Cited by 2 publications

(4 citation statements)

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“…It induces the pacemaker activity of ICC, and then ICC generate and transmit electrical slow wave to the SMC to regulate the contraction and relaxation of SMC. Therefore, ICC serve mediators of enteric motor neurotransmission, and they were involved in neuromuscular signaling transmission since ICC and SMC establish direct contact between them (Lino & Horiguchi, 2006; Yu et al, 2020). Additionally, in the present study, the multivesicular bodies, including exosomes, were observed in close proximity to ICC.…”

Section: Discussionmentioning

confidence: 99%

“…Conventional paraffin sectioning technique was employed to observe the microstructure of the gastric wall of the R. catesbeiana (Yu et al, 2020). The gastric wall samples were removed from the fixative and were washed with water.…”

Section: Methodsmentioning

confidence: 99%

“…TEM was conducted to identify the ultrastructure of ICC (Yu et al, 2020). Small pieces of gastric wall samples were taken from 2.5% glutaraldehyde/PBS and washed in PBS.…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies of ICC were mainly confined to mammals and humans. Compared with mammals, the data of ICC in lower vertebrates, for example the amphibians, is still very limited (Yu et al, 2020). The physiological significance of ICC remains obscure in amphibians and other lower vertebrates (Miyamoto-Kikuta & Komuro, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Ultrastructure and Morphometric Analysis of Interstitial Cells of Cajal in the Gastric Wall of the Bullfrog (Rana catesbeiana)

et al. 2022

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Interstitial cells of Cajal (ICC) play a vital role in the gastrointestinal motility. However, information on ICC in lower vertebrates is rare. Here, ICC and ICC-like features of the gastric wall in the bullfrog (Rana catesbeiana) were observed by light microscopy and transmission electron microscopy. The lengths and distances of the ICC/ICC-like features were measured by morphometric analysis. The gastric wall contained mucosa, submucosa, tunica muscularis, and serosa. The gastric glands contained mucous cells and oxynticopeptic cells. The ICC with 1–3 processes were located among smooth muscle cells (SMC) of the tunica muscularis. Moreover, the ICC-like features were observed among oxynticopeptic cells of the mucosa. The processes of ICC established direct contacts with SMC. Also, the gap junctions were observed between the processes of ICC and nerve fiber bundles in the tunica muscularis. The multivesicular bodies, including shedding exosomes, were frequently observed between ICC and SMC. In addition, ICC-like features and their processes were observed in close proximity to oxynticopeptic cells and blood vessels. Our findings illustrated that ICC are present in the gastric tunica muscularis, and ICC-like features were in the mucosal lamina propria of the gastric wall of R. catesbeiana. These histological evidences supported the notion that ICC are implicated in gastric motility.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…TEM was conducted to identify the ultrastructure of ICC (Yu et al, 2020). Small pieces of gastric wall samples were taken from 2.5% glutaraldehyde/PBS and washed in PBS.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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