Structural Responses of Integrated Parametric Aortic Valve in an Electro-Mechanical Full Heart Model

Morany, Adi; Lavon, Karin; Bluestein, Danny; Hamdan, Ashraf; Haj-Ali, Rami

doi:10.1007/s10439-020-02575-0

Cited by 9 publications

(3 citation statements)

References 45 publications

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“…Several studies demonstrated the capability of LHHM to understand drug-related alterations in cardiac electrophysiology [ 46 ], the impact of the implantable cardioverter defibrillator [ 47 ] and left-ventricular assist device [ 48 ] on cardiac mechanics, the performance of the edge-to-edge repair of mitral valve [ 49 ], and transcatheter heart valve therapies in stenotic aortic valves [ 50 ]. Recently, Morany et al [ 51 ] adapted the LHHM with a patient-specific aortic valve using an approach similar to that used in the present study. They demonstrated the role of kinematic heart behavior on the leaflet coaptation and stress distribution using an electromechanical model with more realistic boundary conditions.…”

Section: Discussionmentioning

confidence: 99%

Patient-Specific Analysis of Ascending Thoracic Aortic Aneurysm with the Living Heart Human Model

et al. 2021

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In ascending thoracic aortic aneurysms (ATAAs), aneurysm kinematics are driven by ventricular traction occurring every heartbeat, increasing the stress level of dilated aortic wall. Aortic elongation due to heart motion and aortic length are emerging as potential indicators of adverse events in ATAAs; however, simulation of ATAA that takes into account the cardiac mechanics is technically challenging. The objective of this study was to adapt the realistic Living Heart Human Model (LHHM) to the anatomy and physiology of a patient with ATAA to assess the role of cardiac motion on aortic wall stress distribution. Patient-specific segmentation and material parameter estimation were done using preoperative computed tomography angiography (CTA) and ex vivo biaxial testing of the harvested tissue collected during surgery. The lumped-parameter model of systemic circulation implemented in the LHHM was refined using clinical and echocardiographic data. The results showed that the longitudinal stress was highest in the major curvature of the aneurysm, with specific aortic quadrants having stress levels change from tensile to compressive in a transmural direction. This study revealed the key role of heart motion that stretches the aortic root and increases ATAA wall tension. The ATAA LHHM is a realistic cardiovascular platform where patient-specific information can be easily integrated to assess the aneurysm biomechanics and potentially support the clinical management of patients with ATAAs.

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Section: Discussionmentioning

confidence: 99%

Patient-Specific Analysis of Ascending Thoracic Aortic Aneurysm with the Living Heart Human Model

et al. 2021

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“…Data were anonymized and collected after approval from the hospital institutional review board committees (RMC 0636 approval) adhering to the Declaration of Helsinki. Following a protocol from our previous study [ 38 ], contrast-enhanced and electrocardiography-gated CT scans were acquired using a 256-channel volume CT scanner (Brilliance iCT, Philips Healthcare, Cleveland, OH, USA) with an in-plane resolution of 0.67 × 0.67 mm and slice thickness of 0.67 mm. At the diastolic phase, data from 19 severe aortic stenosis patients, 7 males and 12 females, was extracted from retrospective electrocardiogram (ECG)-gated cardiac CT scans, on 75% of the R-R interval.…”

Section: Methodsmentioning

confidence: 99%

Analysis of fibrocalcific aortic valve stenosis: computational pre-and-post TAVR haemodynamics behaviours

Morany,

Bardon,

Lavon

et al. 2024

R. Soc. Open Sci.

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Fibro-calcific aortic valve (AV) diseases are characterized by calcium growth or accumulation of fibrosis in the AV tissues. Fibrocalcific aortic stenosis (FAS) rises specifically in females, like calcification-induced aortic stenosis (CAS), may eventually necessitate valve replacement. Fluid-structure-interaction (FSI) computational models for severe CAS and FAS patients were developed using lattice Boltzmann method and multi-scale finite elements (FE). Three parametric AV models were introduced: pathology-free of non-calcified tri-and-bicuspid AVs with healthy collagen fibre network (CFN), a FAS model incorporated a thickened CFN with embedded small calcification volumes, and a CAS model employs healthy CFN with embedded high calcification volumes. The results indicate that the interaction between calcium deposits, adjacent tissue and fibres crucially influences haemodynamics and structural reactions. A fourth model of transcatheter aortic valve replacement (TAVR) post-procedure outcomes was created to study both CAS and FAS. TAVR-CAS had a higher maximum contact pressure and lower anchoring area than TAVR-FAS, making it prone to aortic tissue damage and migration. Finally, although the TAVR-CAS offered a larger opening area, its paravalvular leakage was higher. This may be attributed to a similar thrombogenicity potential characterizing both models. The computational framework emphasizes the significance of mechanobiology in FAS and underscores the requirement for tissue modelling at multiple scales.

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“…The difficulty of cardiovascular system modelling arises from its multifunctionality and compartmentalized nonlinear structure. In order to overcome this issue, due to the difficulties encountered in integrating modelling of the whole system, instead of modelling all the subsystems of the real system, it is preferred to model some parts of it independently [6], in order to reduce the problem complexity, and developing cardiovascular system new models can produce healthy hemodynamic data that mimic diseases to certain extent [7]. The hemodynamic measurements of a healthy person with a modified Windkessel model were used to analyze the hemodynamic data of congenital heart diseases, such as hypoplastic left heart syndrome (HLHS) [8].…”

Section: Introductionmentioning

confidence: 99%

The New HEMS Modelling of Human Heart

KIZILKAPLAN

Yalcinkaya

2022

Balkan Journal of Electrical and Computer Engineering

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The new version of the hydro-electro-mechanical system (HEMS) is modeled via 14 serially connected electrical equivalent circuits resulting in an integrated equivalent circuit. The new model accepts a group of variables and even examines the interaction between them. This paper introduces an improved integrated new model of the heart by replacing the monolithic equivalent structures with segmental comprehensive equivalents. Windkessel Model (WM) is a model of the relationships between aorta, aortic valve and left ventricle. Based on WM, the integrated new model was developed and simulated. The model’s main focus is to define the dynamic properties of the system by a set of ordinary differential equations, and solving them using Ode23, a method for the solution of a closed-loop system. Using Matlab based Ode23 method; time-dependency of pressure, volume and flow were obtained. In case, short computation time and high accuracy are needed, then ode23 is used. The model may be used to analyze complex processes in the heart and blood vessels. The new HEMS model has potential use for hemodynamic simulation of diseases, cardiovascular disorders, and special congenital heart diseases; such as ASD, VSD and PDA.

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Structural Responses of Integrated Parametric Aortic Valve in an Electro-Mechanical Full Heart Model

Cited by 9 publications

References 45 publications

Patient-Specific Analysis of Ascending Thoracic Aortic Aneurysm with the Living Heart Human Model

Patient-Specific Analysis of Ascending Thoracic Aortic Aneurysm with the Living Heart Human Model

Analysis of fibrocalcific aortic valve stenosis: computational pre-and-post TAVR haemodynamics behaviours

The New HEMS Modelling of Human Heart

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