Structural stability of DHMAI antibacterial dental composite following in vitro biological aging

Cherchali, Fatima Zohra; Attik, Nina; Mouzali, M.; Tommasino, Jean Bernard; Abouelleil, Hazem; Decoret, Dominique; Seux, Dominique; Grosgogeat, Brigitte

doi:10.1016/j.dental.2020.05.006

Cited by 9 publications

(10 citation statements)

References 31 publications

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“…Thus, cell membrane permeability is changed, and the target bacteria dissolve and die [ 122 ]. At present, these naturally used QAC monomers include dimethyl hexadecyl methacryloxyethyl iodide (DHMAI), dimethylaminohexadecyl methacrylate (DMAHDM), 12-methacryloyloxy dodecylpyridinium bromide (MDPB), methacryloyloxyethyl hexadecyl ammonium chloride (DMAE-CB) and so forth [ 121 , 123 , 124 ]. They have a stable structure and remarkable antibacterial effect.…”

Section: Ways To Reduce Biodegradationmentioning

confidence: 99%

Biodegradation of Dental Resin-Based Composite—A Potential Factor Affecting the Bonding Effect: A Narrative Review

Guo

Gao

et al. 2022

Biomedicines

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In recent years, although resin composite has played an important role in the restoration of tooth defects, it still has several disadvantages, including being biodegraded by saliva, bacteria and other enzymes in the oral cavity, which may result in repair failure. This factor is not conducive to the long-term survival of the prosthesis in the mouth. In this article, we review the causes, influencing factors and prevention methods of resin biodegradation. Biodegradation is mainly caused by esterase in saliva and bacteria, which breaks the ester bond in resin and causes the release of monomers. The mechanical properties of the prosthesis can then be affected. Meanwhile, cathepsin and MMPs are activated on the bonding surface, which may decompose the dentin collagen. In addition, neutrophils and residual water on the bonding surface can also aggravate biodegradation. Currently, the primary methods to prevent biodegradation involve adding antibacterial agents to resin, inhibiting the activity of MMPs and enhancing the crosslinking of collagen fibers. All of the above indicates that in the preparation and adhesion of resin materials, attention should be paid to the influence of biodegradation to improve the prosthesis’s service life in the complex environment of the oral cavity.

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Section: Ways To Reduce Biodegradationmentioning

confidence: 99%

Biodegradation of Dental Resin-Based Composite—A Potential Factor Affecting the Bonding Effect: A Narrative Review

Guo

Gao

et al. 2022

Biomedicines

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“…Monomethacrylates with only one methacrylate group are the first generation of QAMs and the polymer network of high-concentration monomethacrylate resin blended into the composite resin may inevitably affect its structure and mechanical properties due to the low crosslinking density [ 23 ]. To overcome this issue, QAMs with more than two methacrylate groups have been synthesized [ 79 , 80 , 81 , 82 ]. He et al synthesized IPhene, a quaternary ammonium di-methacrylate monomer with an iodine counter-anion.…”

Section: Current Antimicrobial Strategies Of Resin Compositesmentioning

confidence: 99%

“…They then investigated the structural stability and resistance against biodegradation of DHMAI-loaded experimental composites. The results showed that dental composites based on DHMAI possibly enhanced dental composite longevity [ 79 ]. Jaymand et al conducted a series of studies on multi-functional dendritic monomers and found that they can be used to improve the crosslinking degree and performance of resins [ 84 , 85 , 86 , 87 ].…”

Section: Current Antimicrobial Strategies Of Resin Compositesmentioning

confidence: 99%

Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Sun¹,

Zhang²,

Bai³

et al. 2021

Polymers

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Repairing tooth defects with dental resin composites is currently the most commonly used method due to their tooth-colored esthetics and photocuring properties. However, the higher than desirable failure rate and moderate service life are the biggest challenges the composites currently face. Secondary caries is one of the most common reasons leading to repair failure. Therefore, many attempts have been carried out on the development of a new generation of antimicrobial and therapeutic dental polymer composite materials to inhibit dental caries and prolong the lifespan of restorations. These new antimicrobial materials can inhibit the formation of biofilms, reduce acid production from bacteria and the occurrence of secondary caries. These results are encouraging and open the doors to future clinical studies on the therapeutic value of antimicrobial dental resin-based restoratives. However, antimicrobial resins still face challenges such as biocompatibility, drug resistance and uncontrolled release of antimicrobial agents. In the future, we should focus on the development of more efficient, durable and smart antimicrobial dental resins. This article focuses on the most recent 5 years of research, reviews the current antimicrobial strategies of composite resins, and introduces representative antimicrobial agents and their antimicrobial mechanisms.

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Section: Introductionmentioning

confidence: 99%

“…Methacrylates with QA groups include monomethacrylates (mono-QAMs) [ 15 , 16 , 17 , 18 , 19 , 20 , 21 ] and dimethacrylates (di-QAMs) [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. Mono-QAMs such as 12-methacryloyloxydodecylpyridinium bromide [ 15 ], and N,N-dimethylaminoethyl methacrylate (DMAEMA) derivatives with bromide [ 16 , 17 ], iodide [ 18 , 19 , 20 ], or chloride [ 21 ] counter ions were the first to be obtained. DCRMs modified with the above mono-QAMs showed high antibacterial activity against many strains of bacteria, such as Streptococcus mutans , Actinomyces viscosus , and Lactobacillus casei [ 15 , 16 , 17 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and Microbiological Properties of Copolymers Comprising Quaternary Ammonium Urethane-Dimethacrylates with Bisphenol A Glycerolate Dimethacrylate and Triethylene Glycol Dimethacrylate

et al. 2023

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Using dental composite restorative materials with a copolymeric matrix chemically modified towards bioactive properties can help fight secondary caries. In this study, copolymers of 40 wt.% bisphenol A glycerolate dimethacrylate, 40 wt.% quaternary ammonium urethane-dimethacrylates (QAUDMA-m, where m represents 8, 10, 12, 14, 16 and 18 carbon atoms in the N-alkyl substituent), and 20 wt.% triethylene glycol dimethacrylate (BG:QAm:TEGs) were tested for (i) cytotoxicity on the L929 mouse fibroblast cell line; (ii) fungal adhesion, fungal growth inhibition zone, and fungicidal activity against C. albicans; and (iii) bactericidal activity against S. aureus and E. coli. BG:QAm:TEGs had no cytotoxic effects on L929 mouse fibroblasts because the reduction of cell viability was less than 30% compared to the control. BG:QAm:TEGs also showed antifungal activity. The number of fungal colonies on their surfaces depended on the water contact angle (WCA). The higher the WCA, the greater the scale of fungal adhesion. The fungal growth inhibition zone depended on the concentration of QA groups (xQA). The lower the xQA, the lower the inhibition zone. In addition, 25 mg/mL BG:QAm:TEGs suspensions in culture media showed fungicidal and bactericidal effects. In conclusion, BG:QAm:TEGs can be recognized as antimicrobial biomaterials with negligible biological patient risk.

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Structural stability of DHMAI antibacterial dental composite following in vitro biological aging

Cited by 9 publications

References 31 publications

Biodegradation of Dental Resin-Based Composite—A Potential Factor Affecting the Bonding Effect: A Narrative Review

Biodegradation of Dental Resin-Based Composite—A Potential Factor Affecting the Bonding Effect: A Narrative Review

Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Cytotoxicity and Microbiological Properties of Copolymers Comprising Quaternary Ammonium Urethane-Dimethacrylates with Bisphenol A Glycerolate Dimethacrylate and Triethylene Glycol Dimethacrylate

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