Structural Studies, Antimicrobial Activity and Protein Interaction of Photostable Terpyridine Silver(I) Complexes

Abstract

Photostable mono-and binuclear silver(I) complexes derived from terpyridine ligands (4′-(2-pyridyl)-2,2′:6′,2′′-terpyridine (L PY ) (1), 4′-(4-phenyl morpholine)-2,2′:6′,2′′-terpyridine (L morph ) (2) and 1,4-bis (2,2′:6′,2′′-terpyridin-4′yl) benzene (L DB ) (3)) were synthesized and fully characterized in the solution and solid-state including [ 1 H-15 N] heteronuclear multiple bond coherence (HMBC) NMR analysis and single-crystal X-ray analysis of five-coordinates [Ag 2 (L PY ) 2 (CH 3 CN) 2 ](SO 3 CF 3 ) 2 . Based on the NMR and ESI-MS data, complex 1 exists as dimeric species, formed by head-to-tail interaction, while monomeric species [a]

Palladium(II) Complexes of 4‐Phenyl‐3‐thiosemicarbazone Ligands: Insights Into Cytotoxic Properties and Mode of Cell Death

“…Metal‐based compounds may, in general, show outstanding stability in a variety of solvents; but, in vivo , these compounds may differ or may not be appropriate for biological delivery. Conversely, after being provided, biologically active metal‐based molecules have the potential to bind with imidazolyl groups on many proteins that are exposed to the surface [63–65] . Drug distribution and pharmacological characteristics may be impacted by these interactions.…”

“…The planar complexes function as a π‐stacking, whereas the insertors eject the DNA bases. It was possible to spectrophotometrically monitor the binding of metallointercalators to DNA [63–65] . When intercalators bind to DNA, their charge transfer band(s) typically exhibit hypochromism and a slight hypsochromic or hyperchromic shift.…”

“…Conversely, after being provided, biologically active metal- based molecules have the potential to bind with imidazolyl groups on many proteins that are exposed to the surface. [63][64][65] Drug distribution and pharmacological characteristics may be impacted by these interactions. Therefore, we decided to examine the stability of 8-12 in presence of hen-egg white lysozyme (HEWL) (Figure S8).…”

“…It was possible to spectrophotometrically monitor the binding of metallointercalators to DNA. [63][64][65] When intercalators bind to DNA, their charge transfer band(s) typically exhibit hypochromism and a slight hypsochromic or hyperchromic shift. Hyperchromic shift could be brought on by electrostatic and groove modes.…”

Reactivity of azido terpyridine Pd(ii) and Pt(ii) complexes towards 4,4,4-trifluoro-2-butynoic acid: structural insight into the triazolato coordination mode

“…Terephthaldehyde and eight equivalents of 2-acetylpyridine were reacted in a mixture of ammonia and potassium tert-butoxide to produce 1,4-bis (2,2 ′ :6 ′ ,2 ′′ -terpyridin-4 ′ yl) benzene (L) in good yield (77%) and purity. 22 Square-planar complexes 1 and 2 (Scheme 1), with ionic formulas of [Pd 2 Cl 2 L] + and [PtClL] + , respectively, were obtained by reactions of terpyridine ligand L and either Na 2 PdCl 4 (in methanol) or K 2 PtCl 4 (in methanol/ water). Under comparable experimental conditions, it appears that the reaction between the Pd(II) precursor and L afforded a binuclear complex 1, whereas the same reaction with Pt(II) precursor gave a mononuclear complex 2.…”