Structural study and antioxidant activity determination of (2E)-N-[2-(morpholin-4-yl)ethyl]-cinnamanilide

Abstract

Herein we report the structural study and antioxidant activity of (2E)-N-[2-(morpholin-4-yl) ethyl)-cinnamanilide (1) and its salt (1-HCl). Compound 1 crystallizes as orthorhombic P bca system while its salt is monoclinic P2 1 /n. The supramolecular structures are held in shape by classical (D-H⋅⋅⋅A) and non classical (C-H⋅⋅⋅A) interactions. The antioxidant capability of both compounds shows a structural relationship, compound 1 has moderate capability, meanwhile compound 1-HCl increases its properties owing to the presence of N-H + in the structure.

Free radicals, natural antioxidants, and their reaction mechanisms

“…The synthetic antioxidants are the second type of nonenzymatic antioxidants. Cinnamic acid derivatives 130,131 Various in vitro methods are available for the evaluation of antioxidant activity of different compounds. [134][135][136][137] 5.1.…”

PHYTOCHEMICAL SCREENING, ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF EXTRACTS AND FRACTIONS OF Dillenia suffruticosa LEAVES

“…The DPPH radical scavenging activity of extract or fraction was evaluated following the procedure given in the literature (Vélez-González et al, 2008) with slight modification. To each of the 200 µL aliquots of the reference standards (Quercetin or Trolox; 1, 5, 10, 25 and 50 µg mL -1 , dissolved in methanol) or extracts/fractions (1,10,25,50,100,250,500,750 and 1000 µg mL -1 , unless otherwise stated), 1 mL of the 50 µg mL -1 methanolic DPPH solution was added and incubated in the dark for 30 minutes.…”