2013
DOI: 10.1016/j.dyepig.2013.05.001
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Structurally modified indocyanine green dyes. Modification of the polyene linker

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Cited by 22 publications
(30 citation statements)
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“…We believe that the reason for the spectrum shift and quantum yield increase of the rigid dye 8 and the dye-conjugate 12 is due to the more rigid structure of the polyene chain, but the specific structural feature that correlates with these changes is unknown at this time. 22 …”
Section: Discussionmentioning
confidence: 99%
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“…We believe that the reason for the spectrum shift and quantum yield increase of the rigid dye 8 and the dye-conjugate 12 is due to the more rigid structure of the polyene chain, but the specific structural feature that correlates with these changes is unknown at this time. 22 …”
Section: Discussionmentioning
confidence: 99%
“…Fragment 11 was prepared by reaction of commercially available 2-nitroimidazole with ethyl bromoacetate to give 9 , followed by reaction with N-Boc piperazine to give 10 . 22 The coupling agent Pybop, (benzotriazol-1-yloxy) tripyrrolidinophosphonium hexafluorophosphate, was used in dimethylformamide (DMF) for the reaction of 8 with 11 , and final purification of the crude product on C18 reversed phase automated flash column chromatography gave 12 in 31% yield.…”
Section: Methodsmentioning
confidence: 99%
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“…Selectively monitoring an exogenous bioreducible and traceable marker is one of the mainstream methods for hypoxia assessment, where 2‐nitroimidazole derivatives are typically used as the hypoxia tracer for indirect measurements . In contrast to 2‐nitroimidazole derivatives as established radiotracers for positron emission tomography (PET) to image tumor hypoxia, indocyanine green (ICG) conjugates of 2‐nitroimidazole are a novel class of near‐infrared (NIR) fluorescent tumor hypoxia tracers demonstrating superb in vivo detectability and biocompatibility . Built on a fluorophore analogous to the commercial ICG as the scaffold structure, this class of compounds has evolved for three generations as ICG conjugates differing in linker and imidazole structures (Scheme S1).…”
Section: Introductionmentioning
confidence: 99%