Structure activity correlations of biodegradability of DDT analogs

Kapoor, Inder P.; Metcalf, Robert L.; Hirwe, Asha S.; Coats, Joel R.; Khalsa, Mohinder S.

doi:10.1021/jf60186a044

Cited by 61 publications

(29 citation statements)

References 8 publications

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“…The ecological magnification (EM), defined as ppm parent compound in organism/parent compound in water, and biodegradability index (BI), defined as ppm polar products in organism/nonpolar products (6), are used to provide quantitative characterization of the environmental behavior of these organochlorine pesticides.…”

Section: Expeimental Proceduresmentioning

confidence: 99%

“…The laboratory model ecosystem devised in this laboratory (2) has been used to estimate the comparative environmental properties of DDT, methoxychlor, and other DDT analogs (3)(4)(5). These investigations have demonstrated environmental degradative pathways and have provided quantitative data on ecological magnification and biodegradability index (6). This paper presents data on six additional organochlorine pesticides which should be of value in judging their overall effects on environmental quality.…”

mentioning

confidence: 99%

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Model ecosystem studies of the environmental fate of six organochlorine pesticides.

Metcalf¹,

Kapoor²,

Lu³

et al. 1973

Environ Health Perspect

114

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Section: Expeimental Proceduresmentioning

confidence: 99%

mentioning

confidence: 99%

Model ecosystem studies of the environmental fate of six organochlorine pesticides.

Metcalf¹,

Kapoor²,

Lu³

et al. 1973

Environ Health Perspect

114

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“…The aromatic chlorines also contribute however, as molecules with alternative substituents are more labile (Kapoor et al 1970(Kapoor et al , 1972. Replacement of even one of the aromatic chlorines with a methyl substituent has been shown to significantly increase biodegradability (Kapoor et al 1973).…”

Section: Chemistry Of Persistencementioning

confidence: 99%

DDT residues in the environment—A review with a New Zealand perspective

Boul¹

1995

New Zealand Journal of Agricultural Research

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“…A major goal of this study was to establish the role of intrinsic molecular properties such as water solubility, polarity, and lipid/water partitioning in determining the environmental behavior in such quantitative terms as ecological magnification (concentration of parent compound in organism/concentration in water) and biodegradability index (concentration of polar products/concentration of nonpolar products) (15). If suitable correlations can be established, these molecular properties could be useful in predicting the pollutant potentialities of new or proposed environmental contaminants (16,17 …”

Section: Molecular Properties and Environmental Responsesmentioning

confidence: 99%

Environmental Fate and Biodegradability of Benzene Derivatives as Studied in a Model Aquatic Ecosystem

Lu¹,

Metcalf²

1975

Environmental Health Perspectives

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A model aquatic ecosystem is devised for studying relatively volatile organic compounds and simulating direct discharge of chemical wastes into aquatic ecosystems. Six simple benzene derivatives (aniline, anisole, benzoic acid, chlorobenzene, nitrobenzene, and phthalic anhydride) and other important specialty chemicals: hexachlorobenzene, pentachlorophenol, 2,6-diethylaniline, and 3,5,6-trichloro-2-pyridinol were also chosen for study of environmental behavior and fate in the model aquatic ecosystem. Quantitative relationships of the intrinsic molecular properties of the environmental micropollutants with biological responses are established, e.g., water solubility, partition coefficient, ir constant, a constant, ecological magnification, biodegradability index, and comparative detoxication mechanisms, respectively. Water solubility, 7r constant, and a constant are the most significant factors and control the biological responses of the food chain members. Water solubility and 7r constant control the degree of bioaccumulation, and a constant limits the metabolism of the xenobiotics via microsomal detoxication enzymes. These highly significant correlations should be useful for predicting environmental fate of organic chemicals.

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Structure activity correlations of biodegradability of DDT analogs

Cited by 61 publications

References 8 publications

Model ecosystem studies of the environmental fate of six organochlorine pesticides.

Model ecosystem studies of the environmental fate of six organochlorine pesticides.

DDT residues in the environment—A review with a New Zealand perspective

Environmental Fate and Biodegradability of Benzene Derivatives as Studied in a Model Aquatic Ecosystem

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