Structure--Activity Relationships in a Series of Antiarrhythmic and Local Anaesthetic Bicyclic Glycinamides

Abstract

Antiarrhythmic as well as local anaesthetic activities have been reported in a wide variety of synthetic amines, amino esters and amino amides. Noteworthy among these are procaine,1 pro-cainamide2 and lidocaine,3 although there is little apparent correlation of antiarrhythmic activity with chemical structure4 or with other pharmacodynamic responses.® The relationship of chemical structure to local anaesthetic activity, however, has been studied extensively and the literature of basic esters related to procaine6-7 and of basic amides related to lidocaine7-8 has been reviewed.