2012
DOI: 10.1016/j.resp.2011.10.015
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Structure–activity relationships in rodent diaphragm muscle fibers vs. neuromuscular junctions

Abstract: The diaphragm muscle (DIAm) is a highly active muscle of mixed fiber type composition. We hypothesized that consistent with greater activation history and proportion of fatigue-resistant fibers, neuromuscular transmission failure is lower in the mouse compared to the rat DIAm, and that neuromuscular junction (NMJ) morphology will match their different functional demands. Minute ventilation and duty cycle were higher in the mouse than in the rat. The proportion of fatigue-resistant fibers was similar in the rat… Show more

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Cited by 63 publications
(84 citation statements)
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“…Studies examining variability in Pdi amplitude across species may thus illuminate differences in variability as they relate to respiratory system mechanics. For example, the higher respiratory frequency and higher proportion of fatigue-resistant fibers in the DIAm of mice compared to rats (Greising et al, 2013a; Prakash and Sieck, 1998; Sieck et al, 2012) is consistent with the relatively smaller fraction of maximal force generating capacity by the DIAm during ventilatory behaviors.…”
Section: Discussionmentioning
confidence: 65%
“…Studies examining variability in Pdi amplitude across species may thus illuminate differences in variability as they relate to respiratory system mechanics. For example, the higher respiratory frequency and higher proportion of fatigue-resistant fibers in the DIAm of mice compared to rats (Greising et al, 2013a; Prakash and Sieck, 1998; Sieck et al, 2012) is consistent with the relatively smaller fraction of maximal force generating capacity by the DIAm during ventilatory behaviors.…”
Section: Discussionmentioning
confidence: 65%
“…Type IIx and IIb diaphragm fibers have larger cross-sectional area (Greising et al, 2013a, Lewis and Sieck, 1990, Miyata et al, 1995, Prakash et al, 2000, Sieck et al, 2012, Sieck et al, 1989b, Zhan et al, 1997), lower mitochondrial volume densities and oxidative capacities than type I and IIa fibers (Enad et al, 1989, Sieck et al, 1996). Type IIx and IIb fibers display the fastest maximum shortening velocities and generate the greatest specific forces of all fiber types (Geiger et al, 2002, Geiger et al, 2001, Geiger et al, 2000, Geiger et al, 1999).…”
Section: Classification Of Motor Unit Typesmentioning
confidence: 99%
“…In addition, differences in the reserve capacity for force generation by the diaphragm muscle may relate to the mechanical properties of the respiratory system itself. For instance, mice exhibit increased minute ventilation, tidal volume, and duty cycle compared to rat on a weight-adjusted basis (Sieck et al, 2012) as well as reduced lung compliance and increased resistance (Gomes et al, 2000). As a result it would be expected that mice exhibit a reduced reserve capacity for force generation by the diaphragm muscle compared to rats, and consequently, the diaphragm muscle would generate an increased fraction of maximal Pdi during ventilatory behaviors.…”
Section: Ventilatory and Non-ventilatory Behaviorsmentioning
confidence: 99%
“…Previous studies have reported that neuromuscular junction (NMJ) morphology varies across muscle fiber types. For example, NMJs at type I and IIa fibers are smaller and less complex compared with NMJs at type IIx and/or IIb fibers [1]. NMJ is the junction between a motor neuron and a muscle fiber, which directly modulates muscle activity by conducting nerve impulse to induce muscle contractions [2].…”
Section: Introductionmentioning
confidence: 99%