Structure−Activity Studies of Antitumor Agent Irofulven (Hydroxymethylacylfulvene) and Analogues

McMorris, Trevor C.; Yu, Jian; Lira, Ricardo; Dawe, Robin; MacDonald, John R.; Waters, Stephen J.; Estes, Leita A.; Kelner, Michael J.

doi:10.1021/jo010458z

Cited by 23 publications

(22 citation statements)

References 24 publications

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“…334,335 Clearly, the specific aim of these studies is related to selectivity, but ecological concepts also have to be considered. Their interest as additives for fuels was reported later from aliphatic alcohols by a homogeneous or heterogeneous acid catalysis.…”

Section: Glycerol Ether Synthesis Via Acid Catalysismentioning

confidence: 99%

Glycerol Ether Synthesis: A Bench Test for Green Chemistry Concepts and Technologies

et al. 2015

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Section: Glycerol Ether Synthesis Via Acid Catalysismentioning

confidence: 99%

Glycerol Ether Synthesis: A Bench Test for Green Chemistry Concepts and Technologies

et al. 2015

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“…Illudane-type sesquiterpenoids are among the best-known bioactive compounds made by Basidiomycota. They exhibit potent antitumor, antiviral, and antibacterial activity [147][148][149][150][151][152] and have been isolated from several mushrooms [153][154][155][156][157][158][159][160][161][162][163][164][165][166]. Omphalotus olearius was identified decades ago as a prolific producer of anticancer illudin M and S [152,[167][168][169].…”

Section: Sesquiterpenoid Biosynthetic Pathways In Basidiomycotamentioning

confidence: 99%

Biosynthesis of Terpenoid Natural Products in Fungi

Schmidt‐Dannert

2014

Advances in Biochemical Engineering/Biotechnology

108

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Tens of thousands of terpenoid natural products have been isolated from plants and microbial sources. Higher fungi (Ascomycota and Basidiomycota) are known to produce an array of well-known terpenoid natural products, including mycotoxins, antibiotics, antitumor compounds, and phytohormones. Except for a few well-studied fungal biosynthetic pathways, the majority of genes and biosynthetic pathways responsible for the biosynthesis of a small number of these secondary metabolites have only been discovered and characterized in the past 5-10 years. This chapter provides a comprehensive overview of the current knowledge on fungal terpenoid biosynthesis from biochemical, genetic, and genomic viewpoints. Enzymes involved in synthesizing, transferring, and cyclizing the prenyl chains that form the hydrocarbon scaffolds of fungal terpenoid natural products are systematically discussed. Genomic information and functional evidence suggest differences between the terpenome of the two major fungal phyla--the Ascomycota and Basidiomycota--which will be illustrated for each group of terpenoid natural products.

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“…The key features concluded for anti-proliferative activity were α,β-unsaturated ketones and cyclopropylmethyl carbinol. They also publicized that hydroxymethyl group and long chain substitutions could possibly produce better features for curing tumor cells [70].…”

Section: Maitake Mushroomsmentioning

confidence: 99%

Nature curing cancer – review on structural modification studies with natural active compounds having anti-tumor efficiency

Kaur

Verma

2015

Biotechnology Reports

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Cancer treatment has raised many drugs and radiation therapies whose side-effects are visible. Ongoing research throughout the world for effective treatment mainly concentrates on methods either in the form of drugs or therapies against this lethal disease. However returning to ayurvedic roots enlightens the fact that nature has many efficient components with anti-cancerous, anti-proliferating and anti-angiogenesis effects. Evidences confirm the participation of plants extracts in synthesizing many medicines against already existing and even emerging diseases. Structure activity relationship (SAR) studies and structural modifications are helping in observing the basis of compounds characteristics to exhibit inhibitor’s nature against carcinogenic agents by modifying parent compounds for creating an improved and potent compound. Many components are under clinical trials but most of them still need attention. In this review an attempt has been made to focus on the natural components gifted by nature and even included in our diet with their structures and sources that could be supportive in designing drug either by computational methods or by experimental methods.

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Structure−Activity Studies of Antitumor Agent Irofulven (Hydroxymethylacylfulvene) and Analogues

Cited by 23 publications

References 24 publications

Glycerol Ether Synthesis: A Bench Test for Green Chemistry Concepts and Technologies

Glycerol Ether Synthesis: A Bench Test for Green Chemistry Concepts and Technologies

Biosynthesis of Terpenoid Natural Products in Fungi

Nature curing cancer – review on structural modification studies with natural active compounds having anti-tumor efficiency

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