Structure Analysis and Study of Biological Activities of Condensed Tannins from Bruguiera gymnorhiza (L.) Lam and Their Effect on Fresh-Cut Lotus Roots

Chen, Ting; Wang, Qin; Liu, Jiaai; Lu, Yichun; Shi, Yan

doi:10.3390/molecules26051369

Cited by 12 publications

(5 citation statements)

References 45 publications

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“…However, the mass of the EG pancreas was greater than the mass of the CG. According to Liu et al [ 53 ], saponins in some plant species can activate the pancreatic hypertrophic (PI3K/Akt) pathway, causing significant changes in this organ.…”

Section: Discussionmentioning

confidence: 99%

Acute Toxicity of Aqueous Extract from Bredemeyera floribunda Root Bark in an Animal Model

Stela Medeiros,

Medeiros,

Macedo

et al. 2024

The Scientific World Journal

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The medicinal plant Bredemeyera floribunda Willd. is used to treat cardiovascular disease, chronic fatigue, low libido, as well as increased diuresis. However, studies considering the toxicity of this plant are scarce. Develop an aqueous extract of B. floribunda considering traditional use and determine the average lethality (LD50), signs, and symptoms of toxicity. The B. floribunda extract was obtained by immersing the root bark in ultrapure water for 18 hours at 4°C, under constant stirring. The test extract was administered in a single dose of 2.000 mg/kg by gavage to rats. Signs and symptoms of toxicity were determined according to the Hippocratic screening test and compared with the control group. In addition, a necropsy was performed for macroscopic evaluation of the organs in the abdominal cavity. A powder was obtained from aqueous extracts that showed the same organoleptic characteristics and emulsification capacity as those presented by the fresh root when prepared according to popular tradition. The LD50 was greater than the test dose with three animals surviving. On the other hand, necropsy of dead rats showed necrosis and reduction in lung mass, in addition to the presence of foam and excessive distension of the stomach and intestines. The main symptoms of toxicity were anesthesia, ataxia, sedation, loss of muscle strength, and excessive drowsiness in the first 24 hours. There was no difference between the control and extract groups with regard to body mass, food, and water intake, as well as in macroscopy of the heart, liver, lungs, intestines, spleen, pancreas, and kidneys. The aqueous extract of the B. floribunda was considered nontoxic or of very low toxicity. However, it is capable of altering the activity of the central nervous system and causing disorders in the respiratory and digestive systems.

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Section: Discussionmentioning

confidence: 99%

Acute Toxicity of Aqueous Extract from Bredemeyera floribunda Root Bark in an Animal Model

Stela Medeiros,

Medeiros,

Macedo

et al. 2024

The Scientific World Journal

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“…Peanut skin contains a variety of dietary polyphenols, especially procyanidins, which may be major active components of peanut skin [ 29 ] and are composed of flavan-3-alcohol structural units, and the monomers, mainly including catechin, epicatechin, catechin gallate, epicatechin gallate, and epicatechin gallate, etc. [ 52 ]. The procyanidins can be divided into type A and type B procyanidins according to the different positions of chemical bonds between monomers.…”

Section: Discussionmentioning

confidence: 99%

The Peanut Skin Procyanidins Attenuate DSS-Induced Ulcerative Colitis in C57BL/6 Mice

et al. 2022

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Polyphenols from peanut skin have been reported to possess many beneficial functions for human health, including anti-oxidative, antibacterial, anticancer, and other activities. To date, however, its anti-inflammatory effect and the underlying mechanism remain unclear. In this study, the anti-inflammatory effect of peanut skin procyanidins extract (PSPE) and peanut skin procyanidins (PSPc) were investigated by a dextran sodium sulfate (DSS)-induced colitis mouse model. The results showed that both PSPE and PSPc supplementation reversed the DSS-induced body weight loss and reduced disease activity index (DAI) values, accompanied by enhanced goblet cell numbers and tight junction protein claudin-1 expression in the colon. PSPE and PSPc treatment also suppressed the inflammatory responses and oxidative stress in the colon by down-regulating IL-1β, TNF-α, and MDA expressions. Meanwhile, PSPE and PSPc significantly altered the gut microbiota composition by increasing the relative abundance of Clostridium XlVb and Anaerotruncus, and inhibiting the relative abundance of Alistipes at the genus level. PSPE and PSPc also significantly elevated the production of short-chain fatty acids (SCFAs) in mice with colitis. The correlation analysis suggested that the protective effects of PSPE and PSPc on colitis might be related to the alteration of gut microbiota composition and the formation of SCFAs. In conclusion, the current research indicates that supplementation of PSPE and PSPc could be a promising nutritional strategy for colitis prevention and treatment.

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“…rhynchopetala. These meroterpenoids have been classified as shikimate-meroterpenoids of the tricycloalternarene type (149)(150)(151)(152) and polyketidemeroterpenoids (131)(132)(133)(134)(135)(136)(137)(138)(139)(140)(141)(142)(143)(144)(145)(146)(147)(148), which contain tetraketide moieties derived from 3,5-dimethylors ellinic acid (131-143) and 6-methylsalicylic acid (144), and hexaketide moiety (145)(146)(147)(148), respectively.…”

Section: Meroterpenoidsmentioning

confidence: 99%

“…The antioxidant and polyphenolrich leaves of B. gymnorrhiza can exert hepatoprotective effects by ameliorating liver tissue injury [7]. Condensed tannins from B. gymnorrhiza possessed notable anti-tyrosinase and antioxidant capabilities, effectively inhibiting browning reactions in fresh-cut lotus roots [146]. Ethanol extract of B. sexangula leaves had antioxidant and melanin inhibition activities without skin irritation [145] [113].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Chemical Constituents and Biological Activities of Bruguiera Genus and Its Endophytes: A Review

Luo,

Chen,

Zhang

et al. 2024

Marine Drugs

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The genus Bruguiera, a member of the Rhizophoraceae family, is predominantly found in coastal areas as a mangrove plant, boasting a rich and diverse community of endophytes. This review systematically compiled approximately 496 compounds derived from both the Bruguiera genus and its associated endophytes, including 152 terpenoids, 17 steroids, 16 sulfides, 44 alkaloids and peptides, 66 quinones, 68 polyketides, 19 flavonoids, 38 phenylpropanoids, 54 aromatic compounds, and 22 other compounds. Among these, 201 compounds exhibited a spectrum of activities, including cytotoxicity, antimicrobial, antioxidant, anti-inflammatory, antiviral, antidiabetic, insecticidal and mosquito repellent, and enzyme inhibitory properties, etc. These findings provided promising lead compounds for drug discovery. Certain similar or identical compounds were found to be simultaneously present in both Bruguiera plants and their endophytes, and the phenomenon of their interaction relationship was discussed.

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Structure Analysis and Study of Biological Activities of Condensed Tannins from Bruguiera gymnorhiza (L.) Lam and Their Effect on Fresh-Cut Lotus Roots

Cited by 12 publications

References 45 publications

Acute Toxicity of Aqueous Extract from Bredemeyera floribunda Root Bark in an Animal Model

Acute Toxicity of Aqueous Extract from Bredemeyera floribunda Root Bark in an Animal Model

The Peanut Skin Procyanidins Attenuate DSS-Induced Ulcerative Colitis in C57BL/6 Mice

Chemical Constituents and Biological Activities of Bruguiera Genus and Its Endophytes: A Review

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