Structure and Activity of Thiazole-Type Schistosomicidal Agents

Synthesis, X-ray Analysis, Biological Evaluation and Molecular Docking Study of New Thiazoline Derivatives

“…Motivated by the above-mentioned results, numerous design and synthesis efforts have been employed to develop new derivatives with more effective and safer therapeutic profiles [15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30]. Additionally, heterocycles based on a thiazoline-2-thione core may undergo several chemical reactions, including alkylation, oxidation, and cycloaddition, as a result of having two different nitrogenous and sulfurous groups [31,32,33,34,35,36,37]. There are many methods for preparing thiazoline-2-thione derivatives from alkyl ammonium dithiocarbamates with the appropriate α-halocompound in the presence of an acid [38,39,40,41,42] or by using primary amines, CS 2 and α-haloketone in DMF [43] or toluene [44] or in water as a solvent [45], or without solvent or catalyst [46].…”

Synthesis and Studies of Potential Antifungal and Antibacterial Agents New Aryl Thiazolyl Mercury (II) Derivatives Compounds

“…In 1889, the �rst thiazole derivative was obtained by Popp et al ey provided 2amino thiazole structure by diazotation. ey are present in vitamin B1 [13] too. iazoles are such compounds applicable as antihyperglycemic [5].…”

“…ey are also in insecticides and antivermin compounds related to agriculture. Due to having two different nitrogenous and sulfurous groups, the compounds tend to attend such different chemical reactions as alkylation, oxidation, and cycloaddition [8][9][10][11][12][13][14][15]. High reactivity of the compounds has caused in many derivatives from them, which there are atoms of nitrogen, sulfur, and carbon being between them [16].…”

Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile

“…Heterocyclic compounds containing thiazole moiety were found to exhibit a wide spectrum of biological activities such as antioxidant (8), antitubercular (9,10), diuretic (11), antischizophrenia (12), antibacterial (13,14), anti-inflammatory (15), anti-HIV (16), antihypertensive (17), antiallergic (18), hypnotic (19), analgesic (20), antitumor and cytotoxic (21,22). Thiazole moiety is present in many drugs such as thiamine (vitamin B 1 ), penicillin (antibiotic), sulfathiazole (antibacterial drug), 2-(4-chlorophenyl)thiazole-4-ylacetic (anti-inflammatory agent), thiabendazole [2-(4-thiazolyl)benzimidazole] (anthelmintic and fungicide), and niridazole [1-(5-nitro-2-thiazolyl)-2-imidazolidinone] (schistosomicidal agent) (23,24). Some thiazole derivatives have been recently proven to be anticancer agents (25).…”