Structure and antiinflammatory activity of isonicotinic and nicotinic amides

Bukhtiarova, T. A.; Trinus, F. P.; Danilenko, V. F.; Danilenko, G. I.; Ovrutskii, V. M.; Sharykina, N. I.

doi:10.1007/bf02464277

Cited by 3 publications

(3 citation statements)

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“…Anti-viral medication Amizon (Amizonum Ò , Farmak Ltd, Ukraine) served as a positive control. Amizon or l-methyl-4-(benzylaminocarbonyl) pyridinium iodide [4], CAS Registry Number: 201349-37-3 is a low toxicity compound with well established anti-viral properties [22] that has been used for influenza prophylaxis and treatment. Tamiflu (F. Hoffmann-La Roshe Ltd., Switzerland) and Rimantadine (OlainFarm, Latvia) were used in study of orthomyxoviruses only.…”

Section: Methodsmentioning

confidence: 99%

New functionally-enhanced soy proteins as food ingredients with anti-viral activity

et al. 2015

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Respiratory viruses are a major public health problem because of their prevalence and high morbidity rate leading to considerable social and economic implications. Cranberry has therapeutic potential attributed to a comprehensive list of phytochemicals including anthocyanins, flavonols, and unique A-type proanthocyanidins. Soy flavonoids, including isoflavones, have demonstrated anti-viral effects in vitro and in vivo. Recently, it was demonstrated that edible proteins can efficiently sorb and concentrate cranberry polyphenols, including anthocyanins and proanthocyanins, providing greatly stabilized matrices suitable for food products. The combination of cranberry and soy phytoactives may be an effective dietary anti-viral resource. Anti-viral properties of both cranberry juice-enriched and cranberry pomace polyphenol-enriched soy protein isolate (CB-SPI and CBP-SPI) were tested against influenza viruses (H7N1, H5N3, H3N2), Newcastle disease virus and Sendai virus in vitro and in ovo. In our experiments, preincubation with CB-SPI or CBP-SPI resulted in inhibition of virus adsorption to chicken red blood cells and reduction in virus nucleic acid content up to 16-fold, however, CB-SPI and CBP-SPI did not affect hemagglutination. Additionally, CB-SPI and CBP-SPI inhibited viral replication and infectivity more effectively than the commercially available anti-viral drug Amizon. Results suggest CB-SPI and CBP-SPI may have preventative and therapeutic potential against viral infections that cause diseases of the respiratory and gastro-intestinal tract.

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Section: Methodsmentioning

confidence: 99%

New functionally-enhanced soy proteins as food ingredients with anti-viral activity

et al. 2015

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“…The title compound can be synthesized from N-benzylamide 4-pyridinecarboxylic acid C 5 H 4 NCONHCH 2 C 6 H 5 and methyl iodide MeI in a 1:2 (Trinus et al, 1994) or 1:1.2 (Buhtiarova et al, 1997) molar ratio. N-Benzylamide 4-pyridinecarboxylic acid, in turn, was synthesized by the condensation of isonicotinic acid C 5 H 4 NCOOH with benzylamine C 6 H 5 CH 2 NH 2 taken in a 1:2 molar ratio (Trinus et al, 1994).…”

Section: Synthesis and Crystallizationmentioning

confidence: 99%

Crystal structure of 4-benzylcarbamoyl-1-methylpyridin-1-ium iodide: an efficient multimodal antiviral drug

Drebushchak¹,

Kryukov²,

Rogova³

et al. 2017

Acta Cryst E

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In the title compound, [MeC 5 H 4 NCONHCH 2 C 6 H 5 ]I or C 14 H 15 N 2 O + ÁI À , a cation and an anion form an ionic pair linked by a strong N-HÁ Á ÁI hydrogen bond. In the crystal, ionic pairs linked by weak C-HÁ Á ÁI hydrogen bonds form infinite ribbons along the crystallographic a axis. Polymorphism screening varying crystallization solvents (water, acetone 90%-water, ethanol 90%-water, 2-propanol 90%-water, DMF, DMSO, methanol, acetonitrile) and conditions (solution temperature, heating and cooling protocols) did not reveal any other polymorphs than the one reported in this work.

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“…Amides bearing a trifluoromethyl substituent show a broad spectrum of pharmacological properties, including antitumour [1], anti-inflammatory [2], antioxidant [3], analgesic [4] and antiviral activity [5]. It was also reported that substituted amides show higher anticonvulsive [6], hypoglycemic [7], antiarrhythmic [8] and fungicidal activity [9].…”

mentioning

confidence: 99%