Structure and bioactivity of colibactin

Wernke, Kevin M.; Xue, Mengzhao; Tirla, Alina; Kim, Chung Sub; Crawford, Jason M.; Herzon, Seth B.

doi:10.1016/j.bmcl.2020.127280

Cited by 59 publications

(61 citation statements)

References 41 publications

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“…Since it was demonstrated that colibactin-producing bacteria cross-link DNA, the group of Crawford and colleagues used DNA as a probe to isolate colibactin from bacterial cultures and elucidated the structure of the colibactin residue when bound to two nucleobases [ 124 ]. Colibactin biosynthesis is not described in this paper since our team and others have extensively reviewed the process previously [ 125 , 126 ].…”

Section: Colibactin-producing E Coli In the Intestinal Microbiotamentioning

confidence: 99%

Gut Microbiota as Potential Biomarker and/or Therapeutic Target to Improve the Management of Cancer: Focus on Colibactin-Producing Escherichia coli in Colorectal Cancer

Véziant

Villéger

Barnich

et al. 2021

Cancers

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The gut microbiota is crucial for physiological development and immunological homeostasis. Alterations of this microbial community called dysbiosis, have been associated with cancers such colorectal cancers (CRC). The pro-carcinogenic potential of this dysbiotic microbiota has been demonstrated in the colon. Recently the role of the microbiota in the efficacy of anti-tumor therapeutic strategies has been described in digestive cancers and in other cancers (e.g., melanoma and sarcoma). Different bacterial species seem to be implicated in these mechanisms: F. nucleatum, B. fragilis, and colibactin-associated E. coli (CoPEC). CoPEC bacteria are prevalent in the colonic mucosa of patients with CRC and they promote colorectal carcinogenesis in susceptible mouse models of CRC. In this review, we report preclinical and clinical data that suggest that CoPEC could be a new factor predictive of poor outcomes that could be used to improve cancer management. Moreover, we describe the possibility of using these bacteria as new therapeutic targets.

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Section: Colibactin-producing E Coli In the Intestinal Microbiotamentioning

confidence: 99%

Gut Microbiota as Potential Biomarker and/or Therapeutic Target to Improve the Management of Cancer: Focus on Colibactin-Producing Escherichia coli in Colorectal Cancer

Véziant

Villéger

Barnich

et al. 2021

Cancers

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“…Colibactin is a genotoxin produced by certain strains of bacteria, such as B2 phylogroup E. coli strains that colonize the human gut [ 88 ]. The synthesis of colibactin by the polyketide synthetase ( pks ) genomic island, especially in members of the family Enterobacteriaceae, may lead to chromosomal instability and DNA damage in eukaryotic cells, apoptosis of immune cells, and in turn the development of CRC [ 89 ].…”

Section: Dysbiosis Inflammation and Toxic Bacterial Metabolitesmentioning

confidence: 99%

Gut Microbiota and Colorectal Cancer Development: A Closer Look to the Adenoma-Carcinoma Sequence

Vacante¹,

Ciuni²,

Burzotta³

et al. 2020

Biomedicines

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There is wide evidence that CRC could be prevented by regular physical activity, keeping a healthy body weight, and following a healthy and balanced diet. Many sporadic CRCs develop via the traditional adenoma-carcinoma pathway, starting as premalignant lesions represented by conventional, tubular or tubulovillous adenomas. The gut bacteria play a crucial role in regulating the host metabolism and also contribute to preserve intestinal barrier function and an effective immune response against pathogen colonization. The microbiota composition is different among people, and is conditioned by many environmental factors, such as diet, chemical exposure, and the use of antibiotic or other medication. The gut microbiota could be directly involved in the development of colorectal adenomas and the subsequent progression to CRC. Specific gut bacteria, such as Fusobacterium nucleatum, Escherichia coli, and enterotoxigenic Bacteroides fragilis, could be involved in colorectal carcinogenesis. Potential mechanisms of CRC progression may include DNA damage, promotion of chronic inflammation, and release of bioactive carcinogenic metabolites. The aim of this review was to summarize the current knowledge on the role of the gut microbiota in the development of CRC, and discuss major mechanisms of microbiota-related progression of the adenoma-carcinoma sequence.

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“…was elucidated 124,125 . Another example concerns the infectious diseases glanders and melioidosis caused by Burkholderia species.…”

Section: Genome-guided Discovery Of Natural Products From Ecological Interactionsmentioning

confidence: 99%

Mining and unearthing hidden biosynthetic potential

2021

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Genetically encoded small molecules (secondary metabolites) play eminent roles in ecological interactions, as pathogenicity factors and as drug leads. Yet, these chemical mediators often evade detection, and the discovery of novel entities is hampered by low production and high rediscovery rates. These limitations may be addressed by genome mining for biosynthetic gene clusters, thereby unveiling cryptic metabolic potential. The development of sophisticated data mining methods and genetic and analytical tools has enabled the discovery of an impressive array of previously overlooked natural products. This review shows the newest developments in the field, highlighting compound discovery from unconventional sources and microbiomes.

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Structure and bioactivity of colibactin

Cited by 59 publications

References 41 publications

Gut Microbiota as Potential Biomarker and/or Therapeutic Target to Improve the Management of Cancer: Focus on Colibactin-Producing Escherichia coli in Colorectal Cancer

Gut Microbiota as Potential Biomarker and/or Therapeutic Target to Improve the Management of Cancer: Focus on Colibactin-Producing Escherichia coli in Colorectal Cancer

Gut Microbiota and Colorectal Cancer Development: A Closer Look to the Adenoma-Carcinoma Sequence

Mining and unearthing hidden biosynthetic potential

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