Structure and blood compatibility of tetrahedral amorphous hydrogenated carbon formed by a magnetic-field-filter plasma stream

In situ synthesis of hybrid nanocomposite with highly order arranged amorphous metallic copper nanoparticle in poly(2-hydroxyethyl methacrylate) and its potential for blood-contact uses

“…In the case of neutral pH, a limited number of hydroxide ions (OH À ) can be adsorbed on the surface of Cu(0)-pHEMA hybrid, causing the surface charge f to approach a constant value. Accordingly, a surface with an increased negative charge should exhibit improved anti-blood-clotting behavior [5], together with the redox ability of Cu nanoparticles reported earlier, further reinforcing the argument that the hybrids currently prepared should have an improved thromboresistant property. The coagulation of blood consists of a cascade of reactions that can be divided into two pathways -the extrinsic and intrinsic pathways -and platelets can accelerate thrombosis through the secretion of bulk phase agonists, fibrinogen-mediated platelet-platelet aggregation and the acceleration of thrombin production [18].…”

“…The amorphous metallic Cu(0)-pHEMA hybrid showed much improved anti-platelet adhesion behavior over these two well-known groups, with as little as 30% of the adhesion amount of platelet compared to that of neat pHEMA being observed for the hybrids, and improving the anti-platelet adhesion over PSF by about 92%. Although the exchange of electrons from blood proteins to the surface of medical devices has been considered to induce blood coagulation [5], the actual mechanism(s) of adhesion of platelets from whole blood to the hybrid surface is not clearly understood. In spite of the ambiguity, it can be reasonably assumed that the Cu nanoparticles in the pHEMA trigger an electron-transferring process from the amorphous Cu(0) nanoparticles to the blood-clotting proteins.…”

“…This has long been highlighted in the area of blood-contacting devices or implants, where the topological texture, electrical charge and hydrophilic nature of the hybrid surface are of prime importance [1,2]. Much attention has also been paid to the electrochemical behavior of the material's surface in order to inhibit the occurrence of thrombosis [3][4][5]. In general, although this has not yet been officially standardized, a material showing blood compatibility can be characterized in terms of, for instance, platelet adhesion, fibrinogen deposition and clotting time.…”

Differentiation of Osteoblast and Osteoclast Cells on Hydrogenated-Tetrahedral Amorphous Carbon Coated Titanium

“…In the present study, we noticed on the hydrogenated-tetrahedral amorphous carbon (ta-C:H) since it has further improved characteristics of hardness, smoothness and friction wear [15,16]. Moreover, surface roughness of Ti is known to be important for regulation of the osteoblast and the osteoclast differentiation [17,18].…”

Structure and Haemocompatibility of Tetrahedral Amorphous Carbon Films Prepared by Pulsed Laser Ablation

“…Thus, we found that the sp 3 fraction of most ta-C films deposited by laser ablation is greater than 80%, showing that the sample deposited at 50 Hz has a maximum |Q| value, indicating that the sp 3 fraction of this sample is about 90%. The estimation maybe determined using other methods, such as electron energy-loss spectroscopy (EELS) (13) and X-ray photoelectron spectroscopy (XPS). (14) The optical band gaps of these ta-C films determined by the Tauc relationship αE = B(E-E g ) 2 are shown in Fig.…”