Structure and Chromosomal Localization of the Human PD-1 Gene (PDCD1)

Shinohara, Takashi; Taniwaki, Masafumi; Ishida, Yasumasa; Kawaichi, Masashi; Honjo, Tasuku

doi:10.1006/geno.1994.1562

Cited by 212 publications

(147 citation statements)

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“…Programmed cell death 1 (PD-1, CD279) is a type 1 transmembrane protein containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) [1], which is induced upon the activation of CD4 and CD8 T cells as well as B, NKT and myeloid cells [2]. PD-1 has two ligands, PD-L1 (also known as B7-H1 or CD274), constitutively expressed by many tissues and upregulated on activation [3], and PD-L2 (also known as B7-DC or CD273), expressed primarily by activated DC and macrophages [4].…”

Section: Introductionmentioning

confidence: 99%

Programmed cell death 1 (PD‐1) and its ligand PD‐L1 are required for allograft tolerance

2007

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Programmed cell death-1 (PD-1, CD279) and its widely expressed, inducible ligand, PD-L1 (CD274), together dampen T cell activation, but whether they are essential for allograft tolerance is unknown. We show, using gene-deficient mice and blocking mAbs in wild-type mice, that costimulation blockade is ineffectual in PD-1 -/-or PD-L1 -/-allograft recipients, or in wild-type allograft recipients treated with anti-PD-1 or anti-PD-L1 mAb. Alloreactive PD-1 -/-CD4 and CD8 T cells had enhanced proliferation and cytokine production compared to wild-type controls, and anergy could not be induced in PD-1-deficient CD4 T cells. We conclude that without inhibitory signals from PD-1 ligation, alloantigen-induced T cell proliferation and expansion cannot be regulated by costimulation blockade, and peripheral tolerance induction cannot occur.

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Section: Introductionmentioning

confidence: 99%

Programmed cell death 1 (PD‐1) and its ligand PD‐L1 are required for allograft tolerance

2007

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“…It is a 50-55-kDa receptor with 23% identity to CTLassociated antigen-4 (CTLA-4) in its Ig domain [7], and is expressed on activated, but not resting, CD4 + and CD8 + T cells, B cells, and myeloid cells [8]. PD-1 has an immunoreceptor tyrosine-based inhibitory motif in its cytoplasmic domain [9][10][11]. Depending on background strain, PD-1 -/-mice develop increased rates of glomerulonephritis, lupus-like arthritis [12], or autoimmune cardiomyopathy [13].…”

Section: Introductionmentioning

confidence: 99%

Paradoxical role of programmed death‐1 ligand 2 in Th2 immune responses in vitro and in a mouse asthma model in vivo

et al. 2004

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Programmed death-1 ligand 2 (PD-L2) is a ligand for programmed death-1 (PD-1), a receptor that plays an inhibitory role in T cell activation. Since previous studies have shown upregulation of PD-L2 expression by Th2 cytokines, and asthma is driven by a Th2 response, we hypothesized that PD-L2 might be involved in regulation of the immune response in this disease. We have found that lungs from asthmatic mice had sustained up-regulation of PD-1 and PD-L2, with PD-L2 primarily on dendritic cells. Although addition of PD-L2-Fc in vitro led to decreased T cell proliferation and cytokine production, administration of PD-L2-Fc in vivo in a mouse asthma model resulted in elevated serum IgE levels, increased eosinophilic and lymphocytic infiltration into bronchoalveolar lavage fluid, higher number of cells in the draining lymph nodes, and production of IL-5 and IL-13 from these cells. Although PD-1 was expressed on regulatory T cells, PD-L2-Fc did not affect regulatory T cell activity in vitro. This study provides in vivo evidence of an exacerbated inflammatory response following PD-L2-Fc administration and indicates a potential role for this molecule in Th2-mediated diseases such as asthma.

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“…À ce jour, trois entités ont été décrites : CTLA-4, PD-1 et BTLA [14][15][16]. Ces molécules sont toutes impliquées dans le contrôle de la tolérance, en déclenchant des seconds signaux inhibiteurs qui vont empêcher, terminer ou atténuer une réponse immune.…”

Section: Corécepteurs Co-inhibiteursunclassified

Corécepteurs lymphocytaires

Olive

2006

Med Sci (Paris)

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Structure and Chromosomal Localization of the Human PD-1 Gene (PDCD1)

Cited by 212 publications

References 0 publications

Programmed cell death 1 (PD‐1) and its ligand PD‐L1 are required for allograft tolerance

Programmed cell death 1 (PD‐1) and its ligand PD‐L1 are required for allograft tolerance

Paradoxical role of programmed death‐1 ligand 2 in Th2 immune responses in vitro and in a mouse asthma model in vivo

Corécepteurs lymphocytaires

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