2004
DOI: 10.1074/jbc.r300035200
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Structure and Function of the Glycine Receptor and Related Nicotinicoid Receptors

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Cited by 76 publications
(61 citation statements)
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References 80 publications
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“…This model was first suggested by hydrophobicity plots of the ligand-gated channels and was recently confirmed by biochemical and crystallographic data from studies with nAChR (2, 28,29,32). Coincidentally, several recent studies showed similar channel gating mechanisms for the LGIC members; involving the ligand-binding domain and the extracellular loop between TM2 and TM3 (32)(33)(34).…”
Section: Discussionmentioning
confidence: 61%
“…This model was first suggested by hydrophobicity plots of the ligand-gated channels and was recently confirmed by biochemical and crystallographic data from studies with nAChR (2, 28,29,32). Coincidentally, several recent studies showed similar channel gating mechanisms for the LGIC members; involving the ligand-binding domain and the extracellular loop between TM2 and TM3 (32)(33)(34).…”
Section: Discussionmentioning
confidence: 61%
“…Fast neurotransmission is mediated by ionotropic receptors, which contain several subunits arranged pseudo-symmetrically around a central ion pore [17,30,36,39,44,47,55,59,65]. Neurotransmitter binding to the receptor causes a conformational change in the receptor, which leads to the opening of the pore and a subsequent change in the firing rate of the target neuron.…”
Section: Introductionmentioning
confidence: 99%
“…Neurotransmitter binding to the receptor causes a conformational change in the receptor, which leads to the opening of the pore and a subsequent change in the firing rate of the target neuron. There are three major families of ionotropic receptors: the 'Cys-loop' receptor family, which includes the nicotinic receptor for acetylcholine, the 5-HT 3 receptor, the GABA A receptor and the glycine receptor [17,36,44,59,65], the glutamate receptor family, comprising the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid, kainate and N-methyl-D-aspartic acid receptors [30,47], and the P2X receptor family [39,55]. Receptors from all three families are often constructed from multiple types of subunits, raising the question of the subunit stoichiometry and arrangement within the receptor.…”
Section: Introductionmentioning
confidence: 99%
“…Other reported actions of NAGly include: both stimulation and inhibition of glycine receptors [49]; inhibition of cyclooxygenase-2 [50]; inhibition of fatty acid amide hydrolase [44,51]; and stimulation of the orphan G-protein coupled receptors GPR18, GPR92 [52,53]. Most of these effects of NAGly are apparent in the low μM range.…”
Section: N-arachidonyl Glycine -An Endogenous Analgesic?mentioning
confidence: 99%