Structure and functions of syndecans in vertebrates

Leonova, E. I.; Galzitskaya, Oxana V.

doi:10.1134/s0006297913100015

Cited by 41 publications

(56 citation statements)

References 56 publications

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“…This is similar to the lipid raft model of mechanotransduction, where the mechanical signal is decentralized and spread throughout the cytoskeleton. The proteoglycans, Syndecans are likely candidates for transducing fluid shear stress into proliferation, differentiation, adhesion and migration [107]. The cytoplasmic domains of syndecans bind to several intracellular proteins including Src kinase and alpha-actinin, and can regulate the organization of the cytoskeleton [100].…”

Section: The Glycocalyxmentioning

confidence: 99%

Mechanoreception at the cell membrane: More than the integrins

Gasparski

Beningo

2015

Archives of Biochemistry and Biophysics

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Section: The Glycocalyxmentioning

confidence: 99%

Mechanoreception at the cell membrane: More than the integrins

Gasparski

Beningo

2015

Archives of Biochemistry and Biophysics

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“…1 Evidence has suggested that aberrant vascular activation and remodeling is a key pathological feature leading to tissue fibrosis and vasculopathy characteristic of SSc. 2 Syndecans are a family of transmembrane heparan sulfate proteoglycans composed of four closely related proteins (syndecan [1][2][3][4]. Syndecans consist of the highly conserved transmembrane and cytoplasmic domains and the variable ectodomains that can be shed from the cell surface by matrix metalloproteinases and exert paracrine and autocrine effects.…”

Section: Introductionmentioning

confidence: 99%

“…This is mainly mediated by their roles as a receptor for extracellular matrix proteins and a reservoir for growth factors through binding via heparan sulfate chains. 3 Different syndecans have distinct distributions in vivo. In adult tissues, syndecan-1 is stably expressed in epithelial and plasma cells, but the detection of syndecan-1 on endothelial cells and other immune cells is seemingly difficult due to its dynamic regulation.…”

Section: Introductionmentioning

confidence: 99%

Serum level of circulating syndecan‐1: A possible association with proliferative vasculopathy in systemic sclerosis

Asano

Taniguchi

et al. 2015

The Journal of Dermatology

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Syndecan-1 is a member of the transmembrane heparan sulfate proteoglycan family, whose membrane-bound and soluble forms are involved in wound healing, inflammation and vascular biology. Because these physiological events are implicated in the pathogenesis of systemic sclerosis (SSc), we investigated the clinical association of serum syndecan-1 levels in this disease. Serum syndecan-1 levels were significantly higher in SSc patients, both in diffuse cutaneous SSc (dcSSc) and limited cutaneous SSc (lcSSc), than in healthy individuals, while comparable between dcSSc and lcSSc groups. In late stage dcSSc patients (disease duration of >6 years), but not non-late stage dcSSc patients (≤6 years), serum syndecan-1 levels were significantly higher than in normal controls. More importantly, SSc patients with elevated serum syndecan-1 levels had higher prevalence of telangiectasia, elevated right ventricular systolic pressure and decreased diffuse capacity of the lung for carbon monoxide than those with normal levels. Therefore, soluble syndecan-1 may be related to the development of proliferative vasculopathy in SSc patients.

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“…Employees continue to work, forming the new relations between the conflicting goals: those that are genuine and those that are proposed by managers (Unsworth, 2014); the organizational situation remains stable or undergoes minor changes. The role of OC in achieving the commitment of personnel and organizational efficiency is also underlined by Russian researchers (Dryakhlov, 2011;Dyrin, 2006;Leonova, 2013;Morgunov, 2010;Zakharova, 2009Zakharova, , 2010Zakharova, , 2012.…”

Section: Introductionmentioning

confidence: 99%

Personal characteristics of effective managers in organizational cultures of different types

Zakharova¹,

Korobeynikova²

2015

Psych. Rus.

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Since the 1990s Russian enterprises have been experiencing difficulties in transitioning to the market-innovative model of development. In the context of the current variability of management paradigms, we had an opportunity to study the internal and external regulators of organizational changes that are typical for a transitioning economy. Organizational culture (OC) was studied as an external factor, while the personal traits of middle managers were viewed as internal factors because these managers are the agents for values and for behavior models, from corporate directives to "front-desk" personnel. The goal of this theoretical and empirical study was to determine the personality traits of middle managers who were deemed effective by top management in companies transitioning to the market-innovative model of development in the context of different types of OCs.During the preliminary stage, we conducted a comparative analysis of the requirements for the personal traits of middle managers who are working in stable conditions as well as in conditions of transfer to the market-innovative model of development, and we selected the relevant methods of empirical research. During the first stage of the empirical part of our research we defined a group of four enterprises with OCs of different types, identified their effective mid-level managers based on expert evaluations by the top leadership, and formed test groups. During the second stage we studied the personal characteristics of these managers.We determined that the personality traits of managers deemed effective by their leaders form integral complexes, which in turn correlate in a certain way with the type of OC of an enterprise. We identified four models of an effective manager: Mentor, Dictator, Innovator, and Businessman; these managers have varying degrees of work productivity, value priorities in the development of OC, personal self-concepts, organizational leadership skills, and types of decision-making. It has been demonstrated that in the evaluation of the effectiveness of a manager of an enterprise, the correspondence of his/her personal traits to the characteristics of the OC prevailing in the company is a more important factor than his/her agreement with the long-term goals of the company and, therefore, with the more promising type of OC. This phenomenon opens a way to utilize such functions of OC as internal integration but prevents external adaptation, which in turn becomes a serious psychological obstacle in the development of an enterprise. 70 L. N. Zakharova, E. V. KorobeynikovaThe OC of an enterprise has a powerful potential to attract employees with certain sets of psychological traits. Important tasks for the psychological support of the organizational development of an enterprise could be the development of a criteria database for the evaluation of managers and the development of a management talent pool based on the market-innovative vector of development of an enterprise with relevant changes in the OC.

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Structure and functions of syndecans in vertebrates

Cited by 41 publications

References 56 publications

Mechanoreception at the cell membrane: More than the integrins

Mechanoreception at the cell membrane: More than the integrins

Serum level of circulating syndecan‐1: A possible association with proliferative vasculopathy in systemic sclerosis

Personal characteristics of effective managers in organizational cultures of different types

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