Structure and hypolipidemic activity of alloside B extracted from anzur onions

Aizikov, M. I.; Kravets, S. D.; Prokhorova, I. R.; Kurmukov, Anvar

doi:10.1007/bf02219011

Cited by 2 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In animal studies, alloside B [ 334 ], isolated from fruits of A. suvorovii and A. stipitatum , exhibited a statistically reliable hypotriglyceridemic activity in experimental hyperlipidemia caused by 1-day starvation, Triton WR-1339 and vitamin D 2 –cholesterol, when compared with lipanthyl (Aizikov et al 1995 ).…”

Section: Biological and Pharmacological Properties Of Alliumentioning

confidence: 99%

Steroidal saponins from the genus Allium

et al. 2014

View full text Add to dashboard Cite

Steroidal saponins are widely distributed among monocots, including the Amaryllidaceae family to which the Allium genus is currently classified. Apart from sulfur compounds, these are important biologically active molecules that are considered to be responsible for the observed activity of Allium species, including antifungal, cytotoxic, enzyme-inhibitory, and other. In this paper, literature data concerning chemistry and biological activity of steroidal saponins from the Allium genus has been reviewed.Electronic supplementary materialThe online version of this article (doi:10.1007/s11101-014-9381-1) contains supplementary material, which is available to authorized users.

show abstract

Section: Biological and Pharmacological Properties Of Alliumentioning

confidence: 99%

Steroidal saponins from the genus Allium

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Strong antioxidant properties through improving the cellular antioxidant enzymes, increasing glutathione storage, decreasing the lipoprotein susceptibility to oxidation, and scavenging the free radicals have also been established for plants belonging to Allium genus ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

The effects of hydroalcoholic extract of Allium elburzense Wendelbo bulb on dexamethasone-induced dyslipidemia, hyperglycemia, and oxidative stress in rats

et al. 2018

View full text Add to dashboard Cite

Recent evidences have suggested the beneficial cardiovascular effects of some plants belonging to the genus Allium. The present study is an attempt to investigate the effects of hydroalcoholic extract of Allium elburzense bulb on dexamethasone-induced dyslipidemia in rats. Total phenolic content of A. elburzense bulb hydroalcoholic extract was determined using Folin-Ciocalteu method. Thirty-six male Wistar albino rats in 6 groups were studied. Group 1 (dyslipidemic control) received dexamethasone (10 mg/kg/day, s.c.) for 7 days, groups 2-4 (treated) received dexamethasone and simultaneously treated orally with 100, 200, or 400 mg/kg of A. elburzense extract, group 5 (normal control) received a single daily injection of normal saline (1 mL/kg, s.c.) and the vehicle orally, and group 6 (reference) received dexamethasone and atorvastatin (40 mg/kg) orally. At the end of experiment, blood glucose, lipid profile, and malondialdehyde (MDA) levels were assessed in serum samples. Livers were processed for histopathological examination. Total phenolic content of A. elburzense extract was estimated to be 33.52 ± 1.3% mg gallic acid equivalent/g of the dried plant extract. The plant extract significantly reduced serum blood glucose, triglyceride, total cholesterol, low-density lipoprotein-cholesterol, and MDA levels and increased the high density lipoprotein-cholesterol level and also improved liver steatosis compared to the dyslipidemic control group. These results suggest the hydroalcoholic extract of A. elburzense bulb has anti-dyslipidemic, anti-hyperglycemic, and antioxidant effects on rats receiving high doses of dexamethasone.

show abstract

Structure and hypolipidemic activity of alloside B extracted from anzur onions

Cited by 2 publications

References 8 publications

Steroidal saponins from the genus Allium

Steroidal saponins from the genus Allium

The effects of hydroalcoholic extract of Allium elburzense Wendelbo bulb on dexamethasone-induced dyslipidemia, hyperglycemia, and oxidative stress in rats

Contact Info

Product

Resources

About