The effects of hydroalcoholic extract of Allium elburzense Wendelbo bulb on dexamethasone-induced dyslipidemia, hyperglycemia, and oxidative stress in rats

Abstract

Recent evidences have suggested the beneficial cardiovascular effects of some plants belonging to the genus Allium. The present study is an attempt to investigate the effects of hydroalcoholic extract of Allium elburzense bulb on dexamethasone-induced dyslipidemia in rats. Total phenolic content of A. elburzense bulb hydroalcoholic extract was determined using Folin-Ciocalteu method. Thirty-six male Wistar albino rats in 6 groups were studied. Group 1 (dyslipidemic control) received dexamethasone (10 mg/kg/day, s.c.) for 7 days, groups 2-4 (treated) received dexamethasone and simultaneously treated orally with 100, 200, or 400 mg/kg of A. elburzense extract, group 5 (normal control) received a single daily injection of normal saline (1 mL/kg, s.c.) and the vehicle orally, and group 6 (reference) received dexamethasone and atorvastatin (40 mg/kg) orally. At the end of experiment, blood glucose, lipid profile, and malondialdehyde (MDA) levels were assessed in serum samples. Livers were processed for histopathological examination. Total phenolic content of A. elburzense extract was estimated to be 33.52 ± 1.3% mg gallic acid equivalent/g of the dried plant extract. The plant extract significantly reduced serum blood glucose, triglyceride, total cholesterol, low-density lipoprotein-cholesterol, and MDA levels and increased the high density lipoprotein-cholesterol level and also improved liver steatosis compared to the dyslipidemic control group. These results suggest the hydroalcoholic extract of A. elburzense bulb has anti-dyslipidemic, anti-hyperglycemic, and antioxidant effects on rats receiving high doses of dexamethasone.

Efficacy of Emilia coccinea aqueous extract on inhibition of α-amylase enzyme activity and insulin resistance in dexamethasone treated-rats

“…Insulin sensitizing effect of E. coccinea was tested on the model of dexamethasone-induced insulin resistance in rats. Dexamethasone is a synthetic glucocorticoid widely used for the treatment of inflammation, autoimmune disorders, and preventing rejection in organ transplant recipients [ 21 ]. Despite their therapeutic action, chronic administration of glucocorticoids may lead to hyperglycemia, dyslipidemia, glucose intolerance, insulin resistance, and imbalance in lipid metabolism [ 22 ].…”

Pengaruh Ekstrak Paederia foetida pada Kadar Kolesterol Total Tikus Model Hiperlipidemia yang Diinduksi Deksametason

“…Hasil tersebut sejalan dengan hasil penelitian sebelumnya yang menunjukan adanya peningkatan kadar kolesterol total darah pasca pemberian injeksi deksametason dengan dosis 10 mg/kg (V. R. Santhosh Kumar et al, 2011). Peningkatan kadar kolesterol tersebut terjadi akibat penurunan aktivitas LPL, LCAT dan ekspresi PPAR-γ (Malkawi et al, 2018); (Pan, Cui, Dong, Zhang, & Xing, 2017); (Safaeian, Zolfaghari, Karimi, Talebi, & Ghazvini, 2018). LPL berfungsi sebagai katalisator proses metabolisme trigliserida menjadi asam lemak, sedangkan LCAT berperan dalam proses esterifikasi kolesterol dan maturasi HDL, sehingga gangguan pada LCAT akan menyebabkan gangguan transportasi kolesterol (Norum, 2017).…”

Hypolipidemic and Anti‐Obesity Effects of Hydroalcoholic Extract of Brazilian Red Propolis in a Rodent Model of Dyslipidemia

“…[ 3 ] Therefore, several studies have expounded the use of potentially hypolipidemic substances as a therapeutic strategy for treating dyslipidemia and cardiovascular diseases. [ 4,5 ]…”

“…[3] Therefore, several studies have expounded the use of potentially hypolipidemic substances as a therapeutic strategy for treating dyslipidemia and cardiovascular diseases. [4,5] Most secondary complications caused by hyperlipidemia and obesity are related to the generation of high levels of reactive oxygen species (ROS), elevated oxidative stress, and inflammatory responses. [6][7][8] Experimental studies that aimed at controlling the deleterious effects of high blood lipid content have focused on reducing the oxidative stress and lipid peroxidation caused by dyslipidemia.…”