Structure and properties of biogenic hydroxyapatite bioceramics modified by graphene-like structures

Abstract

Today bone tissue engineering is one of the most used technologies for treat bones injure. Materials containing hydroxyapatite and graphene have received much attention recently. The aim of this study was preparation of biogenic hydroxyapatite bioceramics modified by graphene-like structures investigation effect of graphene on the structure and properties of material. Biogenic hydroxyapatite bioceramics modified by graphene-like structures were successfully prepared by chemical vapor deposition (CVD) method. Subsequently, microstructure, composition, specific surface area, skeleton density, resorption rate in physiological solution and cytotoxicity were evaluated. XRD, IR spectroscopy, micro-Raman spectroscopy and SEM proved graphene oxide’s formation on biogenic hydroxyapatite as well as on silica single crystal for comparison. Although the coating of graphene-like structures on biogenic hydroxyapatite bioceramics reduces the specific surface area, it allows to 4 times increase resorption rate of biogenic hydroxyapatite bioceramics in physiological solution and does not affect the overall assessment of the cytotoxicity. MTT assay established non-cytotoxic effect and indicated a high potential of biogenic hydroxyapatite bioceramics modified by graphene-like structures using CVD method for medical application.

Microstructure and Biocompatibility of Graphene Oxide/BCZT Composite Ceramics via Fast Hot-Pressed Sintering

“…Cahit et al used graphene as a nanocarrier for gold (I)-monoene complexes, and the experimental results showed very favorable adsorption, underscoring the potential of graphene for medical applications [37]. These materials enhance various cellular responses, including adhesion, proliferation, and differentiation, thereby improving the biocompatibility of composites [38,39]. Notably, graphene oxide exhibits considerable potential in biomedical applications, attributed to its nanoscale dimensions, expansive specific surface area, exceptional mechanical strength, significant biocompatibility, elevated electrical conductivity, and antimicrobial capabilities [40,41].…”